A5063366433- Spaceflight effects on biology
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- High Altitude and Hypoxia
- Platelet Disorders and Treatments
- Medical and Biological Ozone Research
- Biomarkers in Disease Mechanisms
- Space Exploration and Technology
- Radiopharmaceutical Chemistry and Applications
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Radioactivity and Radon Measurements
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Circadian rhythm and melatonin
- Telomeres, Telomerase, and Senescence
Belgian Nuclear Research Centre
2016-2025
Ghent University
2016-2025
KU Leuven
1996-2024
University of South Carolina
2024
Maastricht University
2024
Ablynx (Belgium)
2017
Ghent University Hospital
2011
UCLouvain
1995-2000
CHU Dinant Godinne UCL Namur
1991-1998
RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles.Smaller radiolabeled antibody fragments peptides feature highly specific target accumulation, resulting low accumulation healthy tissue, except for kidneys.Nanobodies are smallest (MW < 15 kDa) functional antigen-binding that derived from heavy chain-only camelid antibodies.Here, we show extend kidney retention...
Fibroblast migration is an important aspect of wound healing. Different factors can influence and as such proper In vitro scratch assays are used to examine cellular migration. However, the wide array techniques available reduces reproducibility findings. this paper, we compare two for creation; i.e. exclusion method or scratching cell monolayers. Furthermore, investigate if analysis software influences experimental outcome by comparing both commercially freely software. Besides, effect...
This study focused on the effects induced by a random positioning machine (RPM) FTC-133 thyroid cancer cells and evaluated signaling elements involved in 3-dimensional multicellular tumor spheroid (MCTS) formation. The were cultured RPM, device developed to simulate microgravity, under static 1-g conditions. After 24 h MCTSs swimming culture supernatants found, addition growth of adherent (AD) cells. Cells grown RPM showed higher levels NF-κB p65 protein apoptosis than controls, result also...
Nanobodies show favourable pharmacokinetic characteristics for tumor targeting, including high tumor‐to‐background‐ratios. Labelled with a therapeutic radionuclide, nanobodies could be used as an adjuvant treatment option HER2‐overexpressing minimal residual disease. The radionuclide Lutetium‐177 is linked to the nanobody using bifunctional chelator. choice of chelator affect in vivo behaviour radiolabeled nanobody. Consequently, we compared four different chelators ‐ p‐SCN‐Bn‐DOTA,...
Cone beam CT (CBCT) for dentomaxillofacial paediatric assessment has been widely used despite the uncertainties of risks low-dose radiation exposures. The aim this work was to investigate clinical performance different CBCT acquisition protocols towards optimization Custom-made anthropomorphic phantoms were scanned using a unit in six protocols. slices blinded, randomized and presented three observers, who scored image quality 4-point scale along with their level confidence. Sharpness also...
Abstract Many space missions have shown that prolonged flights may increase the risk of cardiovascular problems. Using a three‐dimensional clinostat, we investigated human endothelial EA.hy926 cells up to 10 days under conditions simulated microgravity (µg) distinguish transient from long‐term effects µg and 1g. Maximum expression all selected genes occurred after min clinorotation. Gene (osteopontin, Fas, TGF‐β 1 ) declined slightly upregulated levels or rose again (caspase‐3) fourth day...
Endothelial cells (ECs) form three-dimensional (3D) aggregates without any scaffold when they are exposed to microgravity simulated by a random positioning machine (RPM) but not under static conditions at gravity. Here we describe delayed type of formation 3D structures ECs that was initiated cultured on desktop RPM remained adherent for the first 5 days spread over neighboring cells, forming little colonies. After 2 weeks, tube-like (TSs) became visible in these cultures. They included...
When incubated under simulated microgravity (s-microg), endothelial cells (EC) form tubular structures that resemble vascular intimas. This delayed formation of 3D EC begins between the 5th and 7th day culturing conditions s-microg, when double-row cell assemblies become visible. With aim learning about this initial phase structure formation, we found NFkappaBp65 protein content was similar in all populations, but gene expression phosphokinase A catalytic subunit, Calpha, extracellular...