A5020297968- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Cardiac Arrest and Resuscitation
- Palliative Care and End-of-Life Issues
- Nitric Oxide and Endothelin Effects
- Lipoproteins and Cardiovascular Health
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Health and Disease Prevention
- Innovative Approaches in Technology and Social Development
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Muscle and Compartmental Disorders
- Nosocomial Infections in ICU
- Childhood Cancer Survivors' Quality of Life
- Poisoning and overdose treatments
- Hormonal Regulation and Hypertension
- Healthcare cost, quality, practices
- Chronic Kidney Disease and Diabetes
- Family and Patient Care in Intensive Care Units
- Medical and Health Sciences Research
RWTH Aachen University
2023-2025
Graz University of Technology
2025
Paracelsus Medizinische Privatuniversität
2018-2024
Nuremberg Hospital
2003-2024
Technology Centre Prague
2024
Korean Council for University Education
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2007-2017
Klinikum Arnsberg
2007
Novartis (Germany)
2002
University of Regensburg
1998-1999
The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among septic shock, but evidence lacking to support the choice either crystalloids or colloids.
Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack evidence regarding its effect on mortality. Download PDF Research Summary. In this multicenter trial, patients with acute myocardial infarction complicated by for whom early revascularization was planned were randomly assigned to receive ECLS plus usual medical (ECLS group) or alone (control group). The primary outcome death from any cause at 30 days. Safety outcomes...
Background . Sound data about the prevalence of acute renal failure (ARF) among patients with severe sepsis and septic shock are lacking. Further, it is not known whether ARF an independent risk factor for mortality in or merely indicator disease severity.
Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination comprising at least 2 antibiotics different mechanisms remains controversial.To compare the effect moxifloxacin and meropenem alone on sepsis-related organ dysfunction.A randomized, open-label, parallel-group trial 600 patients who fulfilled criteria for sepsis or septic shock (n = 298 monotherapy n 302 therapy). was performed 44 intensive care units in...
Background —Impaired endothelium-dependent vasodilation is an early sign of atherosclerosis in hypercholesterolemic patients. We hypothesized that lipid-lowering therapy can improve endothelial function and this effect mainly mediated by increased bioavailability nitric oxide (NO). Methods Results —In a randomized, double-blind, placebo-controlled trial, we studied 29 patients (age, 50±12 years) with hypercholesterolemia (LDL cholesterol ≥160 mg/dL) randomly assigned to receive either...
Background Hypercholesterolemia, a risk factor for cardiovascular disease, is associated with inflammation and hypercoagulability. Both can be mediated by the CD40 system. This study investigated whether system upregulated in patients moderate hypercholesterolemia it influenced therapy hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Methods Results Fifteen 15 healthy control subjects were investigated. CD154 P-selectin analyzed on platelets was monocytes before under statin...
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Background. Parameters of splanchnic regional perfusion, like intramucosal pH (pHi) and pCO2 (pCO2i), may predict outcome in septic shock patients. Continuous venovenous haemofiltration (CVVH) has been considered beneficial haemodynamically unstable In a prospective, randomized, clinical study, we investigated whether CVVH, comparison to intermittent haemodialysis (IHD), is able improve perfusion critically ill
Background:Asymmetrical NG, NG-dimethylarginine (ADMA) is associated with impaired endothelium-dependent vasodilation in humans.
To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock.One-day cross-sectional survey.Representative sample German intensive care units stratified by hospital size.Adult patients with shock.None.Practice recommendations were selected Sepsis Competence Network (SepNet) investigators. External intensivists visited randomly chosen and asked responsible unit director how often these used. Responses "always"...
This paper provides an endorsement of the KDIGO guideline on acute kidney injury; more specifically, part that concerns renal replacement therapy. New evidence has emerged since publication was taken into account, and is commented from a European perspective. Advice given when to start stop therapy in which modalities should be preferentially applied, conditions; how gain access circulation; measure adequacy; dose can recommended.
Abstract Introduction Lung-protective ventilation in patients with ARDS and multiorgan failure, including renal is often paralleled a combined respiratory metabolic acidosis. We assessed the effectiveness of hollow-fiber gas exchanger integrated into conventional renal-replacement circuit on CO 2 removal, acidosis, hemodynamics. Methods In ten ventilated critically ill AKI undergoing renal- respiratory-replacement therapy, effects low-flow removal acidosis compensation were tested by using...
Zusammenfassung In Deutschland qualifiziert sich der Akut- und Notfallmediziner durch eine Facharztweiterbildung in Verbindung mit den Zusatz-Weiterbildungen „Klinische Notfallmedizin“ „Notfallmedizin“ gemäß Vorgaben Landesärztekammern, die auf Empfehlungen Bundesärztekammer beziehen. Eine zentrale Säule gebietsübergreifenden notfallmedizinischen Versorgung stellt das Gebiet Inneren Medizin seinen Schwerpunkten dar. Das vorliegende Curriculum gibt einen umfassenden Überblick über...