A5089974611- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Trauma and Emergency Care Studies
- Infective Endocarditis Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Cardiac Ischemia and Reperfusion
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
Deutsches Herzzentrum der Charité
2023-2025
Charité - Universitätsmedizin Berlin
2021-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022-2025
German Centre for Cardiovascular Research
2022-2025
Humboldt-Universität zu Berlin
2023
Freie Universität Berlin
2023
Massachusetts General Hospital
2016-2020
Beth Israel Deaconess Medical Center
2018-2020
Harvard University
2016-2019
Evaluate the dose-response relationship between intraoperative fluid administration and postoperative outcomes in a large cohort of surgical patients.Healthy humans may live state responsiveness without need for supplementation. Goal-directed protocols driven by such measures are limited their ability to define optimal during surgery.This analysis data on file included 92,094 adult patients undergoing noncardiac surgery with endotracheal intubation 2007 2014 at an academic tertiary care...
Background Inflammatory cardiomyopathy is one of the most common causes sudden cardiac death in young adults. Diagnosis inflammatory remains challenging, and better monitoring tools are needed. We present magnetocardiography as a method to diagnose myocardial inflammation monitor treatment response. Methods Results A total 233 patients were enrolled, with mean age 45 (±18) years, 105 (45%) women. The primary analysis included 209 adult subjects, whom 66 (32%) diagnosed cardiomyopathy, 17...
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Extracorporeal cardiopulmonary resuscitation (ECPR) can be considered in selected patients with refractory cardiac arrest. Given the risk of patient futility and high resource utilisation, identifying ECPR candidates, who would benefit from this therapy, is crucial. Previous studies investigating lactate as a potential prognostic marker have been small inconclusive. In study, it was hypothesised that level (immediately prior to initiation ECPR) clearance (within 24 hours after initiation)...
Postoperative residual neuromuscular blockade continues to be a frequent occurrence with reported incidence rate of up 64%. However, the effect postoperative on health care utilization remains unclear. We conducted retrospective cohort study investigate effects hospital costs (primary outcome), intensive unit admission rate, and length stay (secondary outcomes).
Objectives: Inhalational anesthetics are bronchodilators with immunomodulatory effects. We sought to determine the effect of inhalational anesthetic dose on risk severe postoperative respiratory complications. Design: Prospective analysis data file in surgical cases between January 2007 and December 2015. Setting: Massachusetts General Hospital (tertiary referral center) two affiliated community hospitals. Patients: A total 124,497 adult patients (105,267 study cohort 19,230 validation...
Understanding the clinical features of myocarditis in various age groups is required to identify age-specific disease patterns. The objective this study was examine differences sex distribution and outcomes patients with ages. Patients acute or chronic 3 centers Berlin, Germany from 2005 2021 United States (National Inpatient Sample) 2010 2019 were included. Age examined included "prepubescent" (below 11 years for females below 13 males), adolescents (11 [female] [male] 18 years), young...
Recent advances in machine learning provide new possibilities to process and analyse observational patient data predict outcomes. In this paper, we introduce a processing pipeline for cardiogenic shock (CS) prediction from the MIMIC III database of intensive cardiac care unit patients with acute coronary syndrome. The ability identify high-risk could possibly allow taking pre-emptive measures thus prevent development CS. We mainly focus on techniques imputation missing by generating...
Abstract Acute pulmonary embolism (PE) is a life-threatening condition caused by the thrombo-embolic obstruction of arteries, which often leads to haemodynamic instability, right ventricular failure, and potentially death. Patients with massive or high-risk PE are particularly vulnerable may not respond conventional treatments, necessitating implementation mechanical circulatory support. Here, we discuss recent advancements in diagnosis multidisciplinary management patients highlight need...
Abstract Cardiac arrest is a critical emergency in cardiovascular medicine, requiring rapid, multidisciplinary interventions to enhance patient survival and neurological outcomes. This review explores the unique challenges of managing out-of-hospital (OHCA) in-hospital cardiac (IHCA), with focus on mechanical circulatory support (MCS) extracorporeal cardiopulmonary resuscitation for selected patients. While OHCA management should prioritize rapid transport specialized centres, IHCA may allow...
Abstract Background Recent randomised controlled trials, along with a meta-analysis of individual patient data, have demonstrated that the routine application veno-arterial extracorporeal membrane oxygenation (VA-ECMO) does not confer survival benefit over standard medical therapy in patients experiencing acute myocardial infarction complicated by cardiogenic shock (AMI-CS). Purpose This study sought to determine whether potential complications specifically associated VA-ECMO might...
Abstract Background Out-of-hospital cardiac arrest (OHCA) continues to be associated with high mortality rates. Timely risk assessment is essential inform appropriate therapeutic strategies. However, existing OHCA scores are often based on older medical data, limited registry populations, small sample sizes, specific healthcare contexts, or involve intricate calculations that hinder routine clinical use. Purpose This study sought design a straightforward and accessible prediction tool for...
In this prespecified cohort study, we investigated the influence of postoperative admission to intensive care unit versus surgical ward on health utilization among patients undergoing intermediate-risk surgery.
Summary Background Critical care beds are a limited resource, yet research indicates that recommendations for postoperative critical admission based on patient‐level risk stratification not followed. It is unclear how prioritisation decisions made in real‐world settings and the effect of this outcomes. Methods This was prespecified analysis an observational cohort study adult patients undergoing inpatient surgery, conducted 274 hospitals across UK Australasia during 2017. The primary outcome...
Journal Article Accepted manuscript The Legacy of ECPR - Bridging the Past, Shaping Present, Defining Future Get access Tharusan Thevathasan, Thevathasan Department Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Benjamin Franklin, Berlin, GermanyBerlin Institute Health, GermanyDZHK (German Center for Cardiovascular Research), Germany Search other works by this author on: Oxford Academic Google Scholar Christian Hassager, Hassager...
Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella®) may improve short-term survival and neurological outcomes in selected patients refractory cardiac arrest. However, long-term effects on cardiac, cognitive, physical psychological health need further study. A multidisciplinary post-ECPR outpatient care program was developed at two centers, involving cardiologists,...