A5009303320- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Issues in Pregnancy
- Vascular Procedures and Complications
- Coronary Artery Anomalies
- Potassium and Related Disorders
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
University Medical Centre Mannheim
2016-2025
German Centre for Cardiovascular Research
2015-2024
E Ink (South Korea)
2024
University Medical Center
2015-2023
University of Mannheim
2008-2022
GTx (United States)
2022
Medizinische Fakultät Mannheim
2015-2021
University of Lübeck
2021
Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack evidence regarding its effect on mortality. Download PDF Research Summary. In this multicenter trial, patients with acute myocardial infarction complicated by for whom early revascularization was planned were randomly assigned to receive ECLS plus usual medical (ECLS group) or alone (control group). The primary outcome death from any cause at 30 days. Safety outcomes...
Myocardial infarction is a frequent cause of out-of-hospital cardiac arrest. However, the benefits early coronary angiography and revascularization in resuscitated patients without electrocardiographic evidence ST-segment elevation are unclear.In this multicenter trial, we randomly assigned 554 with successfully arrest possible origin to undergo either immediate (immediate-angiography group) or initial intensive care assessment delayed selective (delayed-angiography group). All had no on...
Abstract Introduction The aim of this study was to evaluate the diagnostic and prognostic value presepsin in patients with severe sepsis septic shock during first week ICU treatment. Methods In total, 116 suspected or were included 24 hours Blood samples for biomarker measurements presepsin, procalcitonin (PCT), interleukin 6 (IL-6), C reactive protein (CRP) white blood cells (WBC) drawn at days 1, 3 8. All followed up six months. Biomarkers tested diagnosis sepsis, prognosis 30-days...
Abstract Objective The study investigates the diagnostic and prognostic value of C-reactive protein (CRP) procalcitonin (PCT) in patients with sepsis septic shock. Background Limited data regarding CRP PCT during course or shock is available. Methods Consecutive from 2019 to 2021 were included monocentrically. Blood samples retrieved day disease onset (day 1), 2, 3, 5, 7, 10. Firstly, for diagnosis a shock, as well discrimination positive blood cultures, was tested. Secondly, tested 30-day...
Percutaneous coronary interventions (PCI) of chronic total occlusions (CTO) have reached high procedural success rates thanks to dedicated equipment, evolving techniques, and worldwide adoption state-of-the-art crossing algorithms.
The study sought to comprehensively investigate the effect of heart failure (HF) pharmacotherapies in patients with HF mildly reduced ejection fraction (HFmrEF). In absence randomized controlled trials, guideline recommendations concerning HF-related therapies HFmrEF are limited.
Extracorporeal life support (ECLS) has been increasingly used in the treatment of severe infarct-related cardiogenic shock last decade. The randomised ECLS-SHOCK trial demonstrated no benefit early routine use on 30-day all-cause death. We herein present mid-term results. At 1-year follow-up, there were significant differences or cardiovascular mortality, neurologic outcome, recurrent myocardial infarction, repeat revascularisation and rehospitalisations for heart failure between ECLS usual...
Background The study investigates the prognostic impact of sex and sex‐related differences in patients hospitalized with heart failure mildly reduced ejection fraction (HFmrEF). More data regarding characterization their outcomes presence HFmrEF are needed. Methods Results Consecutive (ie, left ventricular 41%–49% signs or symptoms HF) were retrospectively included at one institution from 2016 to 2022. Female compared male regard primary end point all‐cause mortality 30 months (median...
Previous studies revealed that patients with Takotsubo cardiomyopathy (TTC) have a higher mortality rate than the general population. Supraventricular tachycardia is well-known complication of TTC. This study was performed to determine short- and long-term prognostic impact atrial fibrillation associated TTC patients. Our institutional database constituted collective 114 diagnosed from 2003 2015. The were divided into two groups according presence (n = 21, 18.4%) or absence 93, 81.5%)...
Abstract Introduction High power short duration (HPSD) ablation proved to be an effective and safe technique for atrial fibrillation (AF). In former case series, a significant amount of postablation coagulation at the catheter tip as well silent cerebral lesions (SCL) in postprocedural magnetic resonance (cMRI) have been identified patients undergoing de‐novo AF ablations with very high 90 W (vHPvSD) using QDot combination novel RF generator (nGEN, Biosense Webster). Therefore, software has...
Studies investigating the prognostic role of platelets commonly include critically ill patients, whereas data regarding impact platelet count in patients admitted with sepsis and septic shock is limited. Therefore, study investigates shock. Consecutive from 2019 to 2021 were included monocentrically. Blood samples retrieved day disease onset (day 1), days 2, 3, 5, 7 10. Firstly, diagnostic value was tested for compared sepsis. Secondly, 30-day all-cause mortality. Statistical analyses...
To evaluate diagnostic and long-term prognostic values of hFABP compared to NT-proBNP troponin I (TnI) in patients presenting the emergency department (ED) suspected acute heart failure (AHF).401 with dyspnea or peripheral edema, 122 suffering from AHF, were prospectively enrolled followed up 5 years. combined versus alone was tested for AHF diagnosis. Prognostic value TnI evaluated models predicting all-cause mortality (ACM) related rehospitalization (AHF-RH) at 1 years, including 11...
Recent hypotheses have suggested the pathophysiological role of catecholamines in evolution Takotsubo syndrome (TTS). The extent cardiac and circulatory compromise dictates use some form supportive therapy. This study was designed to investigate clinical outcomes associated with catecholamine TTS patients. Our institutional database constituted a collective 114 patients diagnosed between 2003 2015. study-patients were subsequently classified into two groups based on need for support during...
This study examines the prognostic impact of C-reactive protein (CRP) and white blood cell (WBC) counts in patients with cardiogenic shock (CS). Data regarding inflammatory biomarkers CS are scarce. All consecutive from 2019 to 2021 admitted a cardiac intensive care unit (ICU) were included at one institution. Laboratory measurements retrieved day admission (i.e., 1), as well days 2, 3, 4, 8. The primary endpoint was 30-day all-cause mortality. Statistical analyses univariate t-tests,...
Abstract Aims Data regarding the characterization and outcomes of patients with heart failure (HF) mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates characteristics prognostic impact native aortic valve diseases (AVD) in HFmrEF. Methods results Consecutive hospitalized HFmrEF (i.e. left ventricular 41–49% signs and/or symptoms HF) were retrospectively included at one institution from 2016 to 2022. The stenosis (AS), regurgitation (AR) mixed AVD (MAVD) was...