Javier Escaned
A5080359871- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac electrophysiology and arrhythmias
Hospital Clínico San Carlos
2016-2025
Universidad Complutense de Madrid
2016-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2015-2025
Centro de Investigación Biomédica en Red
2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024-2025
Instituto de Salud Carlos III
2013-2025
Comunidad de Madrid
2023-2025
Duran i Reynals Hospital
2024
Institut d'Investigació Biomédica de Bellvitge
2024
Ospedale Santa Corona
2024
Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This can be modified lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve stabilization regression. The have long, stable periods but also become unstable at any time, typically due an acute atherothrombotic event caused rupture erosion. However, chronic, most often...
with the European Association for Study of Diabetes (EASD).
Background —PTCA of a coronary stenosis without documented ischemia at noninvasive stress testing is often performed, but its benefit unproven. Coronary pressure–derived fractional flow reserve (FFR) an invasive index severity that reliable substitute for testing. A value 0.75 identifies stenoses with hemodynamic significance. Methods and Results —In 325 patients whom PTCA was planned who did not have ischemia, FFR the measured. If >0.75, were randomly assigned to deferral (deferral...
Coronary revascularization guided by fractional flow reserve (FFR) is associated with better patient outcomes after the procedure than angiography alone. It unknown whether instantaneous wave-free ratio (iFR), an alternative measure that does not require administration of adenosine, will offer benefits similar to those FFR.
Monotherapy with a P2Y12 inhibitor after minimum period of dual antiplatelet therapy is an emerging approach to reduce the risk bleeding percutaneous coronary intervention (PCI).
The purpose of this study was to develop an adenosine-independent, pressure-derived index coronary stenosis severity.Assessment severity with fractional flow reserve (FFR) requires that resistance is stable and minimized. This usually achieved by administration pharmacological agents such as adenosine. In 2-part study, we determine whether there a time when naturally minimized at rest assess the diagnostic efficiency, compared FFR, new adenosine-free over time.A total 157 stenoses were...
This Consensus Document is the first of two reports summarizing views an expert panel organized by European Association Percutaneous Cardiovascular Interventions (EAPCI) on clinical use intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The document appraises role to guide percutaneous coronary interventions (PCIs) in practice. Current evidence regarding impact guidance cardiovascular outcomes summarized, patients or lesions most likely...
This consensus document, a summary of the views an expert panel organized by European Association Percutaneous Cardiovascular Interventions (EAPCI), appraises importance ischaemia with non-obstructive coronary arteries (INOCA). Angina pectoris affects approximately 112 million people globally. Up to 70% patients undergoing invasive angiography do not have obstructive artery disease, more common in women than men, and large proportion INOCA as cause their symptoms. present wide spectrum...
To assess platelet function profiles in diabetic and nondiabetic patients on aspirin clopidogrel therapy, two patient populations were included to investigate the 1) acute effects of a 300-mg loading dose (group 1, n = 52) 2) long-term 2, 120) compared with already treatment. Patients stratified according presence type 2 diabetes. Platelet aggregation was assessed using light transmittance aggregometry (groups 1 2). activation (P-selectin expression PAC-1 binding) determined whole-blood flow...
The clinical value of percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) is not established by randomized trials. This study should compare the benefit PCI vs. optimal medical therapy (OMT) on health status in patients with at least one CTO.Three hundred and ninety-six were enrolled a prospective randomized, multicentre, open-label, controlled trial to treatment OMT 2:1 randomization ratio. primary endpoint was change assessed Seattle angina questionnaire (SAQ)...
Stenting an angiographically intermediate but functionally non-significant stenosis is controversial. Nevertheless, it has been questioned if deferral of a lesion on the basis fractional flow reserve (FFR) measurement, safe, especially long term. Five-year follow-up DEFER trial showed that outcome after percutaneous coronary intervention (PCI) based FFR ≥ 0.75 excellent and was not improved by stenting. The aim this study to investigate validity position very In 325 patients scheduled for...
Outcomes after percutaneous coronary interventions in diabetic patients are shadowed by the increased rate of recurrence compared with nondiabetic patients.We conducted a multicenter, randomized trial to demonstrate efficacy sirolimus-eluting stents standard prevent restenosis de novo lesions native arteries. The primary end point was in-segment late lumen loss as assessed quantitative angiography at 9-month follow-up. stratified diabetes treatment status. One hundred sixty were (80...
Background Quantitative flow ratio ( QFR ) is a novel modality for physiological lesion assessment based on 3‐dimensional vessel reconstructions and contrast velocity estimates. We evaluated the value of online during routine invasive coronary angiography procedural feasibility, diagnostic performance, agreement with pressure‐wire–derived fractional reserve FFR as gold standard in an international multicenter study. Methods Results FAVOR II E‐J (Functional Assessment by Various Flow...
In comparison with non-occlusive lesions, percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) represents a greater challenge for the interventionalist, due to lower procedural success rates, relatively higher incidence complications and increased rate restenosis. The European Registry Chronic Total Occlusion (ERCTO) was created goal evaluating real impact CTO PCI in context, trying analyse rates success, technical information from procedures patient outcome.Data...