A5052190441- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Advanced X-ray and CT Imaging
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Coronary Artery Anomalies
- Cardiac Arrest and Resuscitation
- Cardiomyopathy and Myosin Studies
- Infective Endocarditis Diagnosis and Management
University of Lausanne
2010-2025
Onze Lieve Vrouwziekenhuis Hospital
2016-2025
University Hospital of Lausanne
2020-2024
Cardiovascular Research Center
2004-2024
Hospital Clínico San Carlos
2001-2023
Comprehensive Cardiovascular
2023
University of Liverpool
2019-2023
Aarhus University Hospital
2010-2023
Erasmus MC
2012-2023
University of British Columbia
2023
In patients with multivessel coronary artery disease who are undergoing percutaneous intervention (PCI), angiography is the standard method for guiding placement of stent. It unclear whether routine measurement fractional flow reserve (FFR; ratio maximal blood in a stenotic to normal flow), addition angiography, improves outcomes.In 20 medical centers United States and Europe, we randomly assigned 1005 undergo PCI implantation drug-eluting stents guided by alone or FFR measurements...
Atherosclerotic plaques that lead to acute coronary syndromes often occur at sites of angiographically mild coronary-artery stenosis. Lesion-related risk factors for such events are poorly understood.In a prospective study, 697 patients with underwent three-vessel angiography and gray-scale radiofrequency intravascular ultrasonographic imaging after percutaneous intervention. Subsequent major adverse cardiovascular (death from cardiac causes, arrest, myocardial infarction, or...
The preferred initial treatment for patients with stable coronary artery disease is the best available medical therapy. We hypothesized that in functionally significant stenoses, as determined by measurement of fractional flow reserve (FFR), percutaneous intervention (PCI) plus therapy would be superior to alone.In whom PCI was being considered, we assessed all stenoses measuring FFR. Patients at least one stenosis (FFR, ≤0.80) were randomly assigned FFR-guided (PCI group) or alone...
The clinical significance of coronary-artery stenoses moderate severity can be difficult to determine. Myocardial fractional flow reserve (FFR) is a new index the functional coronary that calculated from pressure measurements made during arteriography. We compared this with results noninvasive tests commonly used detect myocardial ischemia, determine usefulness index.
Severity of coronary artery stenosis has been defined in terms geometric dimensions, pressure gradient-flow relations, resistance to flow and reserve, or maximum capacity after arteriolar vasodilation. A direct relation between flow, however, may only be presumed if the resistances circulation are constant (and minimal) as theoretically is case during In that case, measurements can used predict assess functional severity.A theoretical model was developed for different components circulation,...
We hypothesized that in patients with stable coronary artery disease and stenosis, percutaneous intervention (PCI) performed on the basis of fractional flow reserve (FFR) would be superior to medical therapy.In 1220 disease, we assessed FFR all stenoses were visible angiography. Patients who had at least one stenosis an 0.80 or less randomly assigned undergo FFR-guided PCI plus therapy receive alone. whom more than received alone included a registry. The primary end point was composite death...
Background —PTCA of a coronary stenosis without documented ischemia at noninvasive stress testing is often performed, but its benefit unproven. Coronary pressure–derived fractional flow reserve (FFR) an invasive index severity that reliable substitute for testing. A value 0.75 identifies stenoses with hemodynamic significance. Methods and Results —In 325 patients whom PTCA was planned who did not have ischemia, FFR the measured. If >0.75, were randomly assigned to deferral (deferral...
We assessed the relation between severity of stenosis in a coronary artery and degree impairment myocardial blood flow. Studies laboratory animals have shown that as coronary-artery increases, maximal flow measured after vasodilatation progressively decreases, with concomitant decrease basal However, this has not been carefully documented humans through measurement
We hypothesized that fractional flow reserve (FFR)–guided percutaneous coronary intervention (PCI) would be superior to medical therapy as initial treatment in patients with stable artery disease.
BACKGROUND Experimental studies have shown that fractional flow reserve (defined as the ratio of maximal achievable in a stenotic area to normal flow) can be calculated from coronary pressure measurements only. The objectives this study were validate calculation humans and compare information with derived quantitative angiography. METHODS AND RESULTS Twenty-two patients an isolated, discrete proximal or mid left anterior descending artery stenosis ventricular function studied. Relative...
With advances in technology, the physiological assessment of coronary artery disease patients catheterization laboratory has become increasingly important both clinical and research applications, but this evolved without standard nomenclature or techniques data acquisition measurement. Some questions regarding interpretation, application, outcome related to results also remain unanswered. Accordingly, consensus statement was designed provide background evidence about measurements describe...
Background Coronary arteries without focal stenosis at angiography are generally considered non–flow-limiting. However, atherosclerosis is a diffuse process that often remains invisible angiography. Accordingly, we hypothesized in patients with coronary artery disease, nonstenotic induce decrease pressure along their length due to atherosclerosis. Methods and Results fractional flow reserve (FFR), as indices of conductance, were obtained from 37 10 individuals (group I) 106 62 arteriographic...
Stenting an angiographically intermediate but functionally non-significant stenosis is controversial. Nevertheless, it has been questioned if deferral of a lesion on the basis fractional flow reserve (FFR) measurement, safe, especially long term. Five-year follow-up DEFER trial showed that outcome after percutaneous coronary intervention (PCI) based FFR ≥ 0.75 excellent and was not improved by stenting. The aim this study to investigate validity position very In 325 patients scheduled for...
Background— Bone marrow CD133-postive (CD133 + ) cells possess high hematopoietic and angiogenic capacity. We tested the feasibility, safety, functional effects of use enriched CD133 progenitor after intracoronary administration in patients with recent myocardial infarction. Methods Results— Among 35 acute infarction treated stenting, 19 underwent (12.6±2.2×10 6 cells) 11.6±1.4 days later (group 1) 16 did not 2). At 4 months, left ventricular ejection fraction increased significantly group 1...
Background To assess coronary lesion severity in the catheterization laboratory, several guide wire–based methods have been proposed. The purpose of present study was to compare feasibility and reproducibility flow velocity reserve (CFVR), instantaneous hyperemic diastolic velocity-pressure slope index (IHDVPS), pressure-derived myocardial fractional (FFR myo ). Methods Results From distal pressure signals (0.014-in wires), CFVR, IHDVPS, FFR were computed 15 stenoses (13 patients) under four...
Background— Cardiac resynchronization therapy was shown to reverse left ventricular (LV) remodeling in patients with congestive heart failure (CHF). However, the prediction of benefit is controversial. We aimed investigate predictive factors LV functional recovery and reversed after biventricular pacing. Methods Results— Forty-nine consecutive CHF a wide QRS complex (182±32 ms) were studied by echocardiography before resynchronization. Intraventricular interventricular asynchrony their...