A5044764461- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Advanced Glycation End Products research
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Blood properties and coagulation
- Nitric Oxide and Endothelin Effects
- Pharmacology and Obesity Treatment
- Adipose Tissue and Metabolism
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Natural Antidiabetic Agents Studies
- Vitamin C and Antioxidants Research
- Diabetes Management and Education
MultiMedica
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of Campania "Luigi Vanvitelli"
1995-2024
University of Salerno
2024
ASL Roma
2024
Federico II University Hospital
1995-2024
Fatebenefratelli Hospital
1997-2022
Ospedale Antonio Cardarelli
1994-2021
Boehringer Ingelheim (Norway)
2020
Boehringer Ingelheim (Taiwan)
2020
C-reactive protein CURE Clopidogrel in Unstable Angina to Prevent Recurrent Events CVD cardiovascular disease DALYs disability-adjusted life years DBP diastolic blood
with the European Association for Study of Diabetes (EASD).
Circulating levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) are elevated in diabetic patients. We assessed the role glucose regulation circulating IL-6, TNF-alpha, interleukin-18 (IL-18) subjects with normal or impaired tolerance (IGT), as well effect antioxidant glutathione.Plasma were acutely raised 20 control 15 IGT maintained at mmol/L for 5 hours while endogenous insulin secretion was blocked octreotide. In subjects, plasma IL-18 rose (P<0.01) within 2 clamp...
To explore the possibility that oscillating glucose may outweigh A1C levels in determining risk for cardiovascular diabetes complications.A euinsulinemic hyperglycemic clamp at 5, 10, and 15 mmol/l was given increasing steps as a single "spike" or between basal high over 24 h normal subjects type 2 diabetic patients. Flow-mediated dilatation, marker of endothelial function, plasma 3-nitrotyrosine 24-h urinary excretion rates free 8-iso PGF2 alpha, two markers oxidative stress, were measured...
The mission of the American Diabetes Association is “to prevent and cure diabetes to improve lives all people affected by diabetes.” Increasingly, scientific medical articles (1) commentaries (2) about interventions use terms “remission” “cure” as possible outcomes. Several approved or experimental treatments for type 1 2 (e.g., pancreas islet transplants, immunomodulation, bariatric/metabolic surgery) are curative intent have been portrayed in media a cure. However, defining remission not...
The effects of intermittent and constant high glucose in the formation nitrotyrosine 8-hydroxydeoxyguanosine (markers oxidative stress), as well possible linkage between stress apoptosis endothelial cells, have been evaluated. Stable increased nitrotyrosine, (8-OHdG), levels. However, these were more pronounced glucose. Protein kinase C (PKC) was elevated both such conditions, particularly adding PKC inhibitors bisindolylmaleimide-I LY379196, a specific inhibitor PKC-β isoforms, normalized...
Background: Findings from animal models suggest that selenium supplementation improves glucose metabolism. Objective: To examine the effect of long-term on incidence type 2 diabetes. Design: Secondary analysis a randomized, double-blind, placebo-controlled trial. Setting: Areas low consumption eastern United States. Patients: 1202 persons seen in dermatology clinics who did not have diabetes at baseline. Intervention: Oral administration selenium, 200 μg/d, or placebo. Measurements:...
Background— Postprandial hypertriglyceridemia and hyperglycemia are considered risk factors for cardiovascular disease. Evidence suggests that postprandial induce endothelial dysfunction through oxidative stress; however, the distinct role of these two is a matter debate. Methods Results— Thirty type 2 diabetic patients 20 normal subjects ate 3 different meals: high-fat meal; 75 g glucose alone; meal plus glucose. Glycemia, triglyceridemia, nitrotyrosine, function were assayed during tests....
The positive and negative health effects of dietary carbohydrates are interest to both researchers consumers. International experts on carbohydrate research held a scientific summit in Stresa, Italy, June 2013 discuss controversies surrounding the utility glycemic index (GI), load (GL) response (GR). outcome was consensus statement which recognized importance postprandial glycemia overall health, GI as valid reproducible method classifying foods for this purpose. There that diets low GL were...
Abstract Background Diabetes and periodontitis are chronic non‐communicable diseases independently associated with mortality have a bidirectional relationship. Aims To update the evidence for their epidemiological mechanistic associations re‐examine impact of effective periodontal therapy upon metabolic control (glycated haemoglobin, HbA1C). Epidemiology There is strong that people elevated risk dysglycaemia insulin resistance. Cohort studies among diabetes demonstrate significantly higher...
Hyperglycemia is common and associated with markedly increased mortality rates in patients hospitalized acute coronary syndromes (ACS). Despite the fact that several studies have documented this association, hyperglycemia remains underappreciated as a risk factor, it frequently untreated ACS patients. This large part due to limitations of prior studies, remaining critical gaps our understanding relationship between poor outcomes. The main objective present statement summarize current state...
Low-carbohydrate and low-fat calorie-restricted diets are recommended for weight loss in overweight obese people with type 2 diabetes.To compare the effects of a low-carbohydrate Mediterranean-style or diet on need antihyperglycemic drug therapy patients newly diagnosed diabetes.Single-center, randomized trial. Randomization was computer-generated unstratified. Allocation concealed sealed study folders held central, secure location until participants gave informed consent. Participants...
Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this extends to humans is lacking.
To explore the effect of fluctuating glucose on endothelial cells, human umbilical vein cells were incubated for 14 days in media containing different concentrations: 5 mmol/l, 20 or a daily alternating mmol/l glucose. Apoptosis was studied by methods: viability assay, cell cycle analysis, DNA fragmentation, and morphological analysis. Furthermore, levels Bcl-2 Bax, well known proteins involved apoptosis, evaluated. Stable high induced apoptosis phenomenon accompanied significant decrease...