A5033420150- Diabetes and associated disorders
- Diabetes Treatment and Management
- Diabetes Management and Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Microplastics and Plastic Pollution
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Glaucoma and retinal disorders
- Chronic Disease Management Strategies
- Tensor decomposition and applications
- Air Quality and Health Impacts
- Microbial Metabolism and Applications
- Metabolism, Diabetes, and Cancer
- Health and Lifestyle Studies
- Lipoproteins and Cardiovascular Health
- Vasculitis and related conditions
- MicroRNA in disease regulation
- Diabetes Management and Education
- Nutritional Studies and Diet
- Intraocular Surgery and Lenses
- Immune responses and vaccinations
MultiMedica
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
University of Campania "Luigi Vanvitelli"
2022-2024
University of Salerno
2024
ASL Roma
2024
University of Turin
2018-2019
Ospedale San Giovanni Bosco
2008
Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this extends to humans is lacking.
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (i) reduce cardiovascular and renal events in patients with without type diabetes (T2D). However, the underlying mechanisms are debated. Low-grade inflammation (LGI) is a key driver of vascular complications, suggested to be attenuated by SGLT-2i animal models. Based on specific working hypothesis, here we investigated net effect LGI T2D possible mechanism. We enrolled treated either stable therapy or other glucose-lowering drugs (GLD) (n =...
Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors (i) are a class of lipid-lowering drugs suggested to hold plethora beneficial effects independent their LDL cholesterol-lowering properties.However, the mechanism underlying such observations is debated.Methods: Human aortic endothelial cells (TeloHAEC) were pre-treated with 100 µg/mL PCSK9i evolocumab and then exposed 20 ng/mL IL-6, major driver cardiovascular diseases (CVD), in both naïve state after...
Abstract Background Few studies explored the effect of combination glucose sodium-cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on incidence cardiovascular events in patients with type 2 diabetes (T2D) acute myocardial infarction (AMI). Methods We recruited T2D AMI undergoing percutaneous coronary intervention, treated either SGLT-2i or GLP-1RA for at least 3 months before hospitalization. Subjects HbA1c < 7% admission were considered good...
Patients with type 2 diabetes (T2D) are characterized by blunted immune responses, which affected glycaemic control. Whether control influences the response to COVID-19 vaccines and incidence of SARS-CoV-2 breakthrough infections is unknown. Here we show that poor control, assessed as mean HbA1c in post-vaccination period, associated lower responses an increased T2D patients vaccinated mRNA-BNT162b2. We report data from a prospective observational study enroling healthcare educator workers...
HbA1c variability has emerged as risk factor for cardiovascular diseases in diabetes. However, the impact of on subjects within recommended target been relatively unexplored.Using data from a large database, we studied 101,533 people with type 2 diabetes without diseases. was expressed quartiles standard deviation during three years (exposure phase). The primary composite outcome included non-fatal myocardial infarction, stroke, all-cause mortality and assessed five following first exposure...
MiR-27b is highly expressed in endothelial cells (EC) but its function this context poorly characterized. This study aims to investigate the effect of miR-27b on inflammatory pathways, cell cycle, apoptosis, and mitochondrial oxidative imbalances immortalized human aortic (teloHAEC), umbilical vein (HUVEC), coronary artery (HCAEC) exposed TNF-α. Treatment with TNF-α downregulates expression all EC lines, promotes activation induces alteration reactive oxygen species accumulation, fostering...
A delay in reaching HbA1c targets patients with newly-diagnosed type 2 diabetes (T2D) is associated an increased long-term risk of developing cardiovascular diseases (CVD), a phenomenon referred to as legacy effect. Whether early introduction glucose-lowering drugs proven benefit on CVD can attenuate this unknown. Using data derived from large Italian clinical registry, i.e. the AMD Annals, we identified 251,339 subjects T2D and without at baseline. Through Cox regressions adjusted for...
Cardiovascular risk factor control fluctuates, tends to change over time, and is potentially impacted by multifactorial interactions. Currently, the presence of factors, rather than their variability or interplay with one another, taken into account define population at risk. The association between factors cardiovascular morbidity mortality among patients Type 2 diabetes mellitus (T2DM) remains debatable.Using registry-derived data, we identified 29 471 people T2DM, without disease (CVD)...
The clinical benefit of convalescent plasma (CP) for patients with coronavirus disease (COVID)-19 is still debated. In this systematic review and meta-analysis, we selected 10 randomized trials (RCTs) 15 non-randomized studies (total number = 22,591) CP treatment evaluated two different scenarios: (1) stage recipients (2) donated antibody titer, considering all-cause mortality at the latest follow-up. Our results show that, when provided early stages disease, significantly reduced mortality:...
Intraindividual body weight variability (BWV), that is, the degree of fluctuations over time, is associated with an increased risk cardiovascular diseases (CVDs) in multiple settings. The impact BWV on type 1 diabetes (T1D) remains unclear, despite issues relative to management individuals this condition.
Lifestyle interventions halt the progression of prediabetes to frank type 2 diabetes (T2D). However, feasibility a prevention program promoting tailored on national scale and conducted by primary care physicians is unclear. To explore this issue, general practitioners dislocated in ten different regions throughout Italy enrolled random subjects without known metabolic diseases identify individuals with prescribe them an intervention based physical activity. Using simple stepwise approach,...
The aim of this study was to assess the oxidative stress status in eyes affected by synchysis scintillans and compare it vitreoretinal disorders without scintillans. Human aqueous vitreous humors were obtained during vitrectomy from thirty-seven otherwise healthy patients that randomly chosen among had undergo a 25-gauge pars plana central cavity, for either (n = 16) or 21), such as idiopathic epimacular membrane 12), macular hole 5), rhegmatogenous retinal detachment 4). redox parameters...
AIM: To evaluate whether the Q-switched Nd:YAG laser treatment applied in routine capsulotomy elicits oxidative stress aqueous and vitreous humors. METHODS: Thirty-six patients who had to undergo a 25 gauge pars plana vitrectomy due vitreoretinal disorders were enrolled, 15 of them underwent 7d before posterior capsule opacification (PCO) (Nd:YAG group) while remaining 21 not treated (no group). Samples humors collected during from all for assessment parameters which compared between group...
Lifestyle interventions halt the progression of prediabetes to frank type 2 diabetes (T2D). However, feasibility a prevention program promoting tailored on national scale and conducted by primary care physicians is unclear. General practitioners located in ten different regions throughout Italy enrolled random subjects without known metabolic diseases identify individuals with prescribe them an intervention based physical activity. Using simple stepwise approach, people referring their...
L’emoglobina glicata (HbA1c) rappresenta la principale metrica di misurazione del controllo glicemico nei pazienti diabete. La HbA1c dipende direttamente dal livello medio glucosio nel sangue ma non intercetta le fluttuazioni della glicemia tempo. Dati recenti suggeriscono che ulteriori metriche hanno un valore predittivo per lo sviluppo complicanze Ad esempio, variabilità e dell’HbA1c sembrano entrambi rappresentare fattori rischio indipendenti complicanze. glicemica, misurata come...