A5072886929- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes and associated disorders
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Pancreatic function and diabetes
- Diet and metabolism studies
- Chronic Disease Management Strategies
- Medication Adherence and Compliance
- Cardiac Imaging and Diagnostics
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Education
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Potassium and Related Disorders
- Atrial Fibrillation Management and Outcomes
- Gestational Diabetes Research and Management
- Geriatric Care and Nursing Homes
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Adrenal Hormones and Disorders
- Acute Ischemic Stroke Management
University of Gothenburg
2014-2023
Centre of Registers Vastra Gotaland
2013-2022
Region Västra Götaland
2013-2022
Uddevalla sjukhus
2020-2021
Sahlgrenska University Hospital
2001-2021
National Academy of Medicine
2019
Karolinska Institutet
2018
Örebro University Hospital
2018
Nottingham City Hospital
2018
University of Nottingham
2018
The excess risks of death from any cause and cardiovascular causes among persons with type 2 diabetes various levels glycemic control renal complications are unknown. In this registry-based study, we assessed these according to diabetes.We included patients who were registered in the Swedish National Diabetes Register on or after January 1, 1998. For each patient, five controls randomly selected general population matched age, sex, county. All participants followed until December 31, 2011,...
The excess risk of death from any cause and cardiovascular causes is unknown among patients with type 1 diabetes various levels glycemic control. We conducted a registry-based observational study to determine the according level control in Swedish population diabetes.We included our registered National Diabetes Register after January 1, 1998. For each patient, five controls were randomly selected general matched age, sex, county. Patients followed until December 31, 2011, through for...
Abstract Objective To assess the association between use of sodium glucose cotransporter 2 (SGLT2) inhibitors and seven serious adverse events current concern. Design Register based cohort study. Setting Sweden Denmark from July 2013 to December 2016. Participants A propensity score matched 17 213 new users SGLT2 (dapagliflozin, 61%; empagliflozin, 38%; canagliflozin, 1%) active comparator, glucagon-like peptide 1 (GLP1) receptor agonists. Main outcome measures The primary outcomes were...
<b>Objective</b> To investigate the long term effects of continuous subcutaneous insulin infusion (insulin pump therapy) on cardiovascular diseases and mortality in people with type 1 diabetes. <b>Design </b>Observational study. <b>Setting </b>Swedish National Diabetes Register, Sweden 2005-12. <b>Participants</b> 18 168 diabetes, 2441 using therapy 15 727 multiple daily injections. <b>Main outcome measures</b> Cox regression analysis was used to estimate hazard ratios for outcomes,...
To evaluate the effectiveness and safety of metformin use in clinical practice a large sample pharmacologically treated patients with type 2 diabetes different levels renal function.Observational study between July 2004 December 2010, mean follow-up 3.9 years.Hospital outpatient clinics primary care Sweden.51 675 men women diabetes, registered Swedish National Diabetes Register, on continuous glucose-lowering treatment oral hypoglycaemic agents (OHAs) or insulin.Risks cardiovascular disease...
To evaluate if the lowest target level for glycated haemoglobin (HbA1c) of <6.5% is associated with lower risk retinopathy and nephropathy than less tight control in children adults type 1 diabetes.Population based cohort study.Swedish National Diabetes Registry, January 1998 to 31 December 2017.10 398 diabetes followed from diagnosis, or close thereafter, until end 2017.Relative (odds ratios) different mean levels HbA1c.Mean age participants was 14.7 years (43.4% female), duration 1.3...
OBJECTIVE We assessed the association between A1C and cardiovascular diseases (CVDs) in an observational study of patients with type 1 diabetes followed for 5 years. RESEARCH DESIGN AND METHODS A total 7,454 were studied from Swedish National Diabetes Register (aged 20–65 years, duration 1–35 2002 to 2007). RESULTS Hazard ratios (HRs) fatal/nonfatal coronary heart disease (CHD) per 1% unit increase baseline or updated mean at Cox regression analysis 1.31 1.34 1.26 1.32, respectively, CVD...
<h3>Importance</h3> The association between socioeconomic status and survival based on all-cause, cardiovascular (CV), diabetes-related, cancer mortality in type 2 diabetes has not been examined a setting of persons with equitable access to health care adjustment for important confounders. <h3>Objective</h3> To determine whether income, educational level, marital status, country birth are independently associated CV, diabetes. <h3>Design, Setting, Participants</h3> A study including all 217...
Aims This study aimed to investigate the association between insulin resistance as determined by estimated glucose disposal rate (eGDR), and survival in adults with type 1 diabetes (T1D) Sweden. Material Methods Using Swedish National Diabetes Register, indviduals T1D were included from January 1, 2005 December 31, 2012. Outcomes retrieved healthcare registers. Hazard ratios (HRs) 95% confidence intervals (CIs) calculated for associations eGDR (mg/kg/min) categorized into <4, 4 5.99, 6...
We reassessed the validity of previously reported incidence rates for type 1 diabetes in 0-34 year olds Sweden. estimated new through three nationwide registers.We used capture-recapture methods to assess ascertainment Diabetes Incidence Study Sweden (DISS) and 20-34 age group 2007-2009. examined whether patients aged 34 younger could be Prescribed Drug Register (PDR) via a proxy diagnosis diabetes; men with at least one women prescriptions insulin were included if they had not been given...
International studies on childhood type 1 diabetes (T1D) have focused whole-country mean HbA1c levels, thereby concealing potential variations within countries. We aimed to explore the in across and eight high-income countries best inform international benchmarking policy recommendations.Data were collected between 2013 2014 from 64,666 children with T1D who <18 years of age 528 centers Germany, Austria, England, Wales, U.S., Sweden, Denmark, Norway. used fixed- random-effects models...
Abstract Background and aims Insulin resistance contributes to the development of type 2 diabetes (T2D) is also a cardiovascular risk factor. The aim this study was investigate potential association between insulin measured by estimated glucose disposal rate (eGDR) stroke mortality thereof in people with T2D. Materials methods Nationwide population based observational cohort that included all T2D patients from Swedish national registry 2004 2016 full data on eGDR categorised as following:...
Abstract Objective To investigate the cardiovascular effectiveness of sodium glucose cotransporter 2 (SGLT2) inhibitors in routine clinical practice. Design Cohort study using data from nationwide registers and an active-comparator new-user design. Setting Denmark, Norway, Sweden, April 2013 to December 2016. Participants 20 983 new users SGLT2 dipeptidyl peptidase 4 (DPP4) inhibitors, aged 35-84, matched by age, sex, history major disease, propensity score. Main outcome measures Primary...
Abstract Objective To assess the association between use of sodium-glucose co-transporter 2 (SGLT2) inhibitors and risk serious renal events in data from routine clinical practice. Design Cohort study using an active comparator, new user design nationwide register data. Setting Sweden, Denmark, Norway, 2013-18. Participants 29 887 users SGLT2 (follow-up time: dapagliflozin 66.1%; empagliflozin 32.6%; canagliflozin 1.3%) dipeptidyl peptidase-4 inhibitors, matched 1:1 on basis a propensity...
HbA1c variability has emerged as risk factor for cardiovascular diseases in diabetes. However, the impact of on subjects within recommended target been relatively unexplored.Using data from a large database, we studied 101,533 people with type 2 diabetes without diseases. was expressed quartiles standard deviation during three years (exposure phase). The primary composite outcome included non-fatal myocardial infarction, stroke, all-cause mortality and assessed five following first exposure...
Abstract Aims/hypothesis The reasons underlying a greater association of premature mortality with early-onset type 2 diabetes relative to late-onset disease are unclear. We evaluated the clinical characteristics at diagnosis and broad trajectories in cardiometabolic risk factors over initial years following relation age diagnosis. Methods Our cohort consisted 100,606 individuals newly diagnosed enrolled Swedish National Diabetes Register from 2002 2012. average follow-up time was 2.8 years....
Abstract Aims Although group-level effectiveness of lipid, blood pressure, glucose, and aspirin treatment for prevention cardiovascular disease (CVD) has been proven by trials, important differences in absolute exist between individuals. We aim to develop validate a prediction tool individualizing lifelong CVD people with Type 2 diabetes mellitus (T2DM) predicting life-years gained without myocardial infarction or stroke. Methods results developed validated the Diabetes Lifetime-perspective...
No studies have examined long-term risks for aortic aneurysm (AA) and dissection (AD) or mortality after AA AD hospitalization among patients with type 2 diabetes mellitus (T2DM).
OBJECTIVE Socioeconomic status (SES) is a powerful predictor of cardiovascular disease (CVD) and death. We examined the association in large cohort patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Clinical data from Swedish National Diabetes Register were linked to national registers, whereby information on income, education, marital status, country birth, comorbidities, events was obtained. Patients followed until first incident event, death, or end follow-up. The between...