A5084830170- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and B-cell Immunology
- Biochemical Analysis and Sensing Techniques
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Multiple Sclerosis Research Studies
- Dietary Effects on Health
- MicroRNA in disease regulation
- Immune cells in cancer
- Extracellular vesicles in disease
- Immune responses and vaccinations
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
University of Naples Federico II
2016-2025
Institute for Experimental Endocrinology and Oncology
2016-2025
Ceinge Biotecnologie Avanzate (Italy)
2024
National Research Council
2013-2023
Federico II University Hospital
1998-2022
University of Foggia
2019
MultiMedica
2005-2016
University of Salerno
2012-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2005-2016
Istituto Neurologico Mediterraneo
2015
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for existence multiple physiological functions this hormone rodents. In contrast, information regarding roles humans is limited. Three morbidly obese children, who were congenitally deficient leptin, treated with daily subcutaneous injections recombinant human up to 4 years sustained, beneficial effects on appetite, fat mass,...
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for existence multiple physiological functions this hormone rodents. In contrast, information regarding roles humans is limited. Three morbidly obese children, who were congenitally deficient leptin, treated with daily subcutaneous injections recombinant human up to 4 years sustained, beneficial effects on appetite, fat mass,...
A single family has been described in which obesity results from a mutation the leptin-receptor gene (LEPR), but prevalence of such mutations severe, early-onset not systematically examined.We sequenced LEPR 300 subjects with hyperphagia and severe obesity, including 90 probands consanguineous families, investigated extent to cosegregated affected receptor function. We evaluated metabolic, endocrine, immune function relatives.Of subjects, 8 (3%) had nonsense or missense mutations--7 were...
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG induction immunity monocytes is accompanied strong increase glycolysis and, lesser extent, glutamine metabolism, both an in-vitro model after vaccination mice humans....
Thymic atrophy is a prominent feature of malnutrition. Forty-eight hours' starvation normal mice reduced the total thymocyte count to 13% that observed in freely fed controls, predominantly because diminution cortical CD4+CD8+ subpopulation. Prevention fasting-induced fall level adipocyte-derived hormone leptin by administering exogenous recombinant protected from these starvation-induced thymic changes. The ob/ob mouse, which unable produce functional mutation obese gene, has impaired...
The past few years of research on leptin have provided important information the link between metabolism and immune homeostasis. Adipocytes influence not only endocrine system but also response through several cytokine-like mediators known as adipokines, which include leptin. It is widely accepted that can directly nutritional status pro-inflammatory T helper 1 responses, a decrease plasma concentration during food deprivation lead to an impaired function. Additionally, studies implicated in...
Significance Recent studies have established that metabolic restrains, such as glucose restriction, impair the activities of effector T cells in tumor microenvironment. In same context, a huge expansion activated Treg tissues has been described mice and humans, contributing to suppression protective antitumor immunity. Our data demonstrate Tregs are committed survive proliferate hostile milieu thanks advantage based on combination glycolysis fatty acid synthesis oxidation. This allows...
Hypothalamic amenorrhea (HA) is associated with dysfunction of the hypothalamic-pituitary-peripheral endocrine axes, leading to infertility and bone loss, usually caused by chronic energy deficiency secondary strenuous exercise and/or decreased food intake. Energy also leads hypoleptinemia, which has been proposed, on basis observational studies as well an open-label study, mediate neuroendocrine abnormalities this condition. To prove definitively a causal role leptin in pathogenesis HA, we...
Human CD4(+)CD25(hi)Foxp3(+)CD127(-) Treg and CD4(+)CD25(-)Foxp3(-) Tconv cell functions are governed by their metabolic requirements. Here we report a comprehensive comparative analysis between ex vivo human cells that comprises analyses of the proteomic networks in subcellular compartments. We identified dominant signature at level primarily impacted highly-tuned balance glucose fatty-acid oxidation two types. Ex were highly glycolytic while used predominantly (FAO). When cultured vitro,...
Abstract Recent evidence indicates that leptin modifies T cell immunity, and may provide a key link between nutritional deficiency immune dysfunction. To study the influence of on autoimmunity, susceptibility to experimental autoimmune encephalomyelitis induced by immunization with myelin-derived peptide was examined in leptin-deficient, C57BL/6J-ob/ob mice, or without replacement, wild-type controls. Leptin replacement converted disease resistance mice; this accompanied switch from Th2 Th1...