A5047025446- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Dietary Effects on Health
- Immune cells in cancer
- Multiple Sclerosis Research Studies
- Autophagy in Disease and Therapy
- Protein Tyrosine Phosphatases
- Immunotherapy and Immune Responses
- Pancreatic function and diabetes
- Pregnancy and Medication Impact
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Allergic Rhinitis and Sensitization
- Hematopoietic Stem Cell Transplantation
- Glycogen Storage Diseases and Myoclonus
- Atherosclerosis and Cardiovascular Diseases
- Food Allergy and Anaphylaxis Research
- Mesenchymal stem cell research
- Genetics and Neurodevelopmental Disorders
- Contact Dermatitis and Allergies
Institute for Experimental Endocrinology and Oncology
2014-2025
National Research Council
2016-2021
University of Naples Federico II
2011-2014
University of Salerno
2013
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG induction immunity monocytes is accompanied strong increase glycolysis and, lesser extent, glutamine metabolism, both an in-vitro model after vaccination mice humans....
Metabolic reprogramming is shaped to support specific cell functions since cellular metabolism controls the final outcome of immune response. Multiple sclerosis (MS) an autoimmune disease resulting from loss tolerance against central nervous system (CNS) myelin. alterations T cells occurring during MS are not yet well understood and their studies could have relevance in comprehension pathogenetic events leading self develop novel therapeutic strategies aimed at limiting progression.In this...
Abstract Immunometabolism has been demonstrated to control immune tolerance and the pathogenic events leading autoimmunity. Compelling experimental evidence also suggests that intracellular metabolic programs influence differentiation, phenotype, proliferation, effector functions of anti-inflammatory CD4+CD25+Foxp3+ regulatory T (Treg) cells. Indeed, alterations in metabolism associate with quantitative qualitative impairments Treg cells several pathological conditions. In this review, we...
Leptin is an adipocyte-derived hormone that controls food intake and reproductive immune functions in rodents. In uncontrolled human studies, low leptin levels are associated with impaired responses reduced T-cell counts; however, the effects of replacement on adaptive system have not yet been reported context randomized, controlled studies and/or conditions chronic acquired deficiency. To address these questions, we performed a double-blinded, placebo-controlled trial recombinant...
ObjectiveIn this report we show that the adipocytokine leptin directly modulates autophagy in human CD4+CD25− conventional (Tconv) T cells.ResultsIn vitro treatment with recombinant determined an inhibition of during cell receptor (TCR) stimulation, and phenomenon was dose- time-dependent. The events were secondary to activation mammalian-target rapamycin (mTOR)-pathway induced by leptin, as testified its reversion mTOR rapamycin. At molecular level these phenomena associated Bcl-2...
Abstract Glycogen storage disease type 1b (GSD-1b) is an autosomal-recessive caused by mutation of glucose-6–phosphate transporter and characterized altered glycogen/glucose homeostasis. A higher frequency autoimmune diseases has been observed in GSD-1b patients, but the molecular determinants leading to this phenomenon remain unknown. To address question, we investigated effect on immune cell homeostasis CD4+ T functions. In subjects, found lymphopenia a reduced capacity cells engage...
Abstract Administration of mesenchymal stem cells (MSC) ameliorate experimental autoimmune encephalomyelitis (EAE), a mouse model multiple sclerosis (MS), at both clinical and neuropathological levels. The therapeutic properties MSC in EAE are mainly mediated by the modulation pathogenic immune response, but other neurotropic effects, including decreased demyelination axonal loss as well promotion tissue repair, play also role. Properly controlled phase II trials to explore potential...
The Na + /Ca 2+ exchanger NCX3, recently identified as a myelin membrane component, is involved in the regulation of [Ca ]i during oligodendrocyte maturation. Here NCX3 involvement was studied glycoprotein (MOG)‐induced experimental autoimmune encephalomyelitis (EAE), an animal model multiple sclerosis. Western blotting and quantitative colocalization studies performed wild‐type ncx3 +/+ mice at different stages EAE disease showed that protein intensely upregulated chronic stage, where it...
The increasing need, for point-of-care (POC) testing has prompted a rise, in the popularity of affordable biosensors that are eco-friendly, especially paper based electrochemical sensors. research introduces biodegradable paper-based...
Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests daily and intermittent CR (iCR) people with MS (pwMS) showed improvements fatigue well-being measures. This trial studied the effects 12-week iCR on metabolic, immunological, clinical outcomes pwMS.