A5028509435- Bone health and osteoporosis research
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Vitamin C and Antioxidants Research
- Bone and Joint Diseases
- Growth Hormone and Insulin-like Growth Factors
- Hip and Femur Fractures
- Bone health and treatments
- Bone Metabolism and Diseases
- CAR-T cell therapy research
- Diet and metabolism studies
- Physical Activity and Health
- Hypothalamic control of reproductive hormones
- Radiation Dose and Imaging
- Ultrasound in Clinical Applications
- Manufacturing Process and Optimization
- Immunotherapy and Immune Responses
- Eating Disorders and Behaviors
- Vitamin K Research Studies
- Meta-analysis and systematic reviews
- Dietary Effects on Health
- Total Knee Arthroplasty Outcomes
Brigham and Women's Hospital
2015-2025
Harvard University
2011-2025
University of Manitoba
2023
Diabetes Australia
2022
University of Chicago
2011-2015
Beth Israel Deaconess Medical Center
2009-2014
University of Cambridge
2014
University of Illinois Chicago, Rockford campus
2007-2012
Illinois College
2007-2012
Hadassah Medical Center
2010
Hypothalamic amenorrhea (HA) is associated with dysfunction of the hypothalamic-pituitary-peripheral endocrine axes, leading to infertility and bone loss, usually caused by chronic energy deficiency secondary strenuous exercise and/or decreased food intake. Energy also leads hypoleptinemia, which has been proposed, on basis observational studies as well an open-label study, mediate neuroendocrine abnormalities this condition. To prove definitively a causal role leptin in pathogenesis HA, we...
Vitamin D supplements are widely recommended for bone health in the general population, but data on whether they prevent fractures have been inconsistent.
Although supplemental vitamin D is used to promote bone health in the general population, data from randomized controlled trials (RCTs) have been inconsistent. We determined whether daily, D3 supplementation improves mineral density (BMD) and/or structure. VITamin and OmegA-3 TriaL (VITAL) a double-blind, placebo-controlled RCT of (2000 IU/d) omega-3 fatty acids (1 g/d) 25,871 adults nationwide. This ancillary study included subcohort 771 participants (men ≥50 women ≥55 years; not taking...
Abstract Context It is unclear whether vitamin D supplementation reduces risk of falls, and results from randomized controlled trials (RCTs) are conflicting. Objective The objective this work to determine 2000 IU/day supplemental D3 decreases fall risk. Design VITamin OmegA-3 TriaL (VITAL) a double-blind, placebo-controlled RCT including 25 871 adults, randomly assigned November 2011 March 2014 treated for 5.3 years (median). Setting This nationwide study. Participants Men 50 or older women...
Abstract Context Declining muscle strength and performance in older adults are associated with falls, fractures, premature death. Objective This work aimed to determine whether supplementation vitamin D3 or omega-3 fatty acids vs placebo for 2 years improves physical measures. Methods VITamin D OmegA-3 TriaL (VITAL) was a double-blinded, placebo-controlled randomized trial of supplemental and/or the prevention cancer cardiovascular disease 25 871 US adults. ancillary study completed New...
Leptin is an adipocyte-derived hormone that controls food intake and reproductive immune functions in rodents. In uncontrolled human studies, low leptin levels are associated with impaired responses reduced T-cell counts; however, the effects of replacement on adaptive system have not yet been reported context randomized, controlled studies and/or conditions chronic acquired deficiency. To address these questions, we performed a double-blinded, placebo-controlled trial recombinant...
Traumatic events are associated with psychological and physical health problems for women in the perinatal period (i.e., pregnancy-12-months after childbirth). Despite negative impact of trauma on women, long-term such diverse women's experience during remains understudied.This study explored two research questions: 1) What experiences who have experienced interpersonal traumatic events? And 2) service needs gaps expressed by relating to medical protocols services? These questions were...
Recombinant leptin (metreleptin) treatment restores bone mineral density in women with hypothalamic amenorrhea (HA), a condition characterized by hypoleptinemia, which has adverse impact on health.The objective of the study was to investigate how metreleptin exerts its positive effect metabolism humans.This randomized, double-blinded, placebo-controlled study.The conducted at Beth Israel Deaconess Medical Center (Boston, Massachusetts).Women (n = 18) HA and hypoleptinemia for least 6 months...
Abstract Context Although observational studies show inverse associations between vitamin D status and body weight/adiposity, there are few large randomized controlled trials (RCTs) investigating this relationship. Objective To determine whether D3 supplementation lowers weight or improves composition. Design The VITamin OmegA-3 TriaL (VITAL) was a double-blinded, placebo-controlled RCT including 25 871 US adults. This ancillary study completed in sub-cohort that underwent composition...
Abstract Osteoporosis is a major public health problem among older adults. Forty percent of U.S. adults take multivitamin/multimineral (MVM) supplementation. The effects MVM supplementation on fractures unclear. Preclinical and observational studies suggest that flavanols may have beneficial bone. We conducted an ancillary study to COcoa Supplement Multivitamin Outcomes Study (COSMOS; NCT05232669) designed investigate incident fracture injurious falls in 21 442 COSMOS participants (12 666...
Background: Bone-target agents (BTAs), including denosumab (DMAb), are one of the bone metastasis treatments that should continue indefinitely. However, BTAs may be interrupted in some cases. In osteoporosis, DMAb withdrawal causes a rebound effect characterized by an increased turnover with spine fractures and hypercalcemia; evidence oncology is lacking. Methods: This study aimed to identify amongst lung cancer patients treated for metastases between January 2020 December 2021. Patients who...
AbstractLipoprotein X (LpX) is an abnormal lipoprotein found in conditions such as lecithin:cholesterol acyltransferase deficiency and cholestatic states (e.g., primary biliary cirrhosis sclerosing cholangitis). Management of severe hypercholesterolemia due to LpX with drugs physical removal methods not well established the literature. A case discussed a 51-year-old woman who presented multiple electrolyte abnormalities, xanthomas neuropathy be secondary setting cholangitis. This highlights...