A5077242442- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Sexual Differentiation and Disorders
- Prenatal Screening and Diagnostics
- Uterine Myomas and Treatments
- Sperm and Testicular Function
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Reproductive Health and Contraception
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Maternal and Perinatal Health Interventions
University of Naples Federico II
2016-2025
Federico II University Hospital
2006-2025
Institute for Experimental Endocrinology and Oncology
2018-2023
National Research Council
2020-2023
Universidade Estadual de Campinas (UNICAMP)
2021
University of Perugia
2019
Magna Graecia University
2019
University of Catania
2019
University of Nottingham
2019
Oxford Fertility
2019
Mitochondria play a vital role in the metabolism of energy-containing compounds oocyte cytoplasm to provide adenosine trisphosphate for fertilization and preimplantation embryo development. In this study, ratiometric confocal microscopy with mitochondrion-specific membrane potential-sensitive fluorescence dye JC-1 (5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolyl-carbocyanine iodide) was used measure activity mitochondria human oocytes developing embryos. embryos were characterized...
Human CD4(+)CD25(hi)Foxp3(+)CD127(-) Treg and CD4(+)CD25(-)Foxp3(-) Tconv cell functions are governed by their metabolic requirements. Here we report a comprehensive comparative analysis between ex vivo human cells that comprises analyses of the proteomic networks in subcellular compartments. We identified dominant signature at level primarily impacted highly-tuned balance glucose fatty-acid oxidation two types. Ex were highly glycolytic while used predominantly (FAO). When cultured vitro,...
In reproductive medicine little progress has been achieved regarding the clinical management of patients with a reduced ovarian reserve or poor response (POR) to stimulation exogenous gonadotropins -a frustrating experience for clinicians as well patients. Despite efforts optimize definition this subgroup patients, existing POR criteria unfortunately comprise heterogeneous population and, importantly, do not offer any recommendations handling. Recently, POSEIDON group ( Patient- Oriented...
<h3>Objective</h3> To compare the euploid blastocyst formation rates obtained after follicular phase (FP) versus luteal (LP) stimulation performed in same menstrual cycle a preimplantation genetic diagnosis for aneuploidy testing (PGD-A) program patients with reduced ovarian reserve. <h3>Design</h3> Prospective paired noninferiority observational study. <h3>Setting</h3> Private infertility program. <h3>Patient(s)</h3> Forty-three reserve undergoing PGD-A. <h3>Intervention(s)</h3> Both FP and...
Abstract The prolonged lockdown of health services providing high-complexity fertility treatments –as currently recommended by many reproductive medicine entities– is detrimental for society as a whole, and infertility patients in particular. Globally, approximately 0.3% all infants born every year are conceived using assisted technology (ART) treatments. By contrast, the total number COVID-19 deaths reported so far represents 1.0% expected to occur worldwide over first three months current...
This article represents a viewpoint on the POSEIDON criteria by group of clinicians and embryologists. Its primary objective is to contextualize Poseidon their metric success for relevant Frontiers Research Topic "POSEIDON's Stratification Low Prognosis Patients in ART: The WHY, WHAT, HOW". "Low prognosis" relates with reduced oocyte number, which can be associated low or sometimes normal ovarian reserve aggravated advanced female age. These aspects will ultimately affect number embryos...