A5030847661- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Coenzyme Q10 studies and effects
- Diet, Metabolism, and Disease
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Celiac Disease Research and Management
- Liver Disease Diagnosis and Treatment
- Reproductive System and Pregnancy
- Dietary Effects on Health
- Analytical Methods in Pharmaceuticals
- Inflammasome and immune disorders
- Contact Dermatitis and Allergies
- Antimicrobial agents and applications
- Genomics, phytochemicals, and oxidative stress
- Reproductive Physiology in Livestock
- COVID-19 Impact on Reproduction
Institute for Experimental Endocrinology and Oncology
2015-2025
Fondazione Santa Lucia
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
National Research Council
2017-2023
University of Salerno
2013
University of Naples Federico II
2010-2011
Human CD4(+)CD25(hi)Foxp3(+)CD127(-) Treg and CD4(+)CD25(-)Foxp3(-) Tconv cell functions are governed by their metabolic requirements. Here we report a comprehensive comparative analysis between ex vivo human cells that comprises analyses of the proteomic networks in subcellular compartments. We identified dominant signature at level primarily impacted highly-tuned balance glucose fatty-acid oxidation two types. Ex were highly glycolytic while used predominantly (FAO). When cultured vitro,...
OBJECTIVE Metreleptin has been efficacious in improving metabolic control patients with lipodystrophy, but its efficacy not tested obese type 2 diabetes. RESEARCH DESIGN AND METHODS We studied the role of leptin regulating endocrine adaptation to long-term caloric deprivation and weight loss diabetic subjects over 16 weeks context a double-blinded, placebo–controlled, randomized trial. then performed detailed interventional mechanistic signaling studies humans vivo, ex vitro. RESULTS In...
Abstract The sensing by T cells of metabolic and energetic changes in the microenvironment can determine differentiation, maturation, activation these cells. Although it is known that mammalian target rapamycin (mTOR) gauges nutritonal signals extracellular milieu, not how mTOR metabolism influence CD4+CD25−FOXP3− effector cell (Teff) responses. In this article, we show leptin-induced mTOR, which, turn, controls leptin production signaling, causes a defined cellular, biochemical,...
Background: Previous studies evidenced a link between metabolic dysregulation, inflammation, and neurodegeneration in multiple sclerosis (MS). Objectives: To explore whether increased adipocyte mass expressed as body index (BMI) serum lipids influence cerebrospinal fluid (CSF) inflammation disease severity. Methods: In this cross-sectional study, 140 consecutive relapsing-remitting (RR)-MS patients underwent clinical assessment, BMI evaluation, magnetic resonance imaging scan, blood CSF...
Background: Astrocytes and microglia play an important role in the inflammatory process of multiple sclerosis (MS). We investigated associations between cerebrospinal fluid (CSF) levels glial fibrillary acid protein (GFAP) soluble triggering receptors expressed on myeloid cells-2 (sTREM-2), molecules, clinical characteristics a group patients with relapsing-remitting MS (RRMS). Methods: Fifty-one RRMS participated study. Clinical evaluation CSF collection were performed at time diagnosis....
Metabolic reprogramming is shaped to support specific cell functions since cellular metabolism controls the final outcome of immune response. Multiple sclerosis (MS) an autoimmune disease resulting from loss tolerance against central nervous system (CNS) myelin. alterations T cells occurring during MS are not yet well understood and their studies could have relevance in comprehension pathogenetic events leading self develop novel therapeutic strategies aimed at limiting progression.In this...
Abstract Immunometabolism has been demonstrated to control immune tolerance and the pathogenic events leading autoimmunity. Compelling experimental evidence also suggests that intracellular metabolic programs influence differentiation, phenotype, proliferation, effector functions of anti-inflammatory CD4+CD25+Foxp3+ regulatory T (Treg) cells. Indeed, alterations in metabolism associate with quantitative qualitative impairments Treg cells several pathological conditions. In this review, we...
Abstract Chronic inflammation can associate with autoreactive immune responses, including CD4+ T cell responses to self-Ags. In this paper, we show that the adipocyte-derived proinflammatory hormone leptin affect survival and proliferation of cells in experimental autoimmune encephalomyelitis, an animal model human multiple sclerosis. We found myelin olygodendrocyte glycoprotein peptide 35–55 (MOG35–55)-specific from C57BL/6J wild-type mice could not transfer encephalomyelitis into...
Gene expression, lipidomic and growth impairment findings suggest that the natural history of celiac disease (CD) starts before gluten-induced immune response. Gluten intake in first years life is a controversial risk factor. We aimed to estimate developing CD associated with amount gluten serum inflammatory profile genetically predisposed infants. From an Italian cohort children at for CD, we enrolled 27 who developed (cases) 56 controls matched by sex age. A dietary interview 9, 12, 18, 24...
Abstract Glycogen storage disease type 1b (GSD-1b) is an autosomal-recessive caused by mutation of glucose-6–phosphate transporter and characterized altered glycogen/glucose homeostasis. A higher frequency autoimmune diseases has been observed in GSD-1b patients, but the molecular determinants leading to this phenomenon remain unknown. To address question, we investigated effect on immune cell homeostasis CD4+ T functions. In subjects, found lymphopenia a reduced capacity cells engage...
Oxidative stress is a driver of multiple sclerosis (MS) pathology. We evaluated the effect coenzyme Q10 (CoQ10) on laboratory markers oxidative and inflammation, MS clinical severity.We included 60 relapsing-remitting patients with treated interferon beta1a 44μg (IFN-β1a) CoQ10 for 3 months, IFN-β1a alone more months (in an open-label crossover design). At baseline at 6-month visits, we measured scavenging activity, damage inflammation in peripheral blood, collected data disease...
Fatty liver disease is a serious complication of childhood obesity. Calorie-restricted regimen (RCR) one the effective therapy for this condition. Aim study was to evaluate effect lycopene-rich tomato sauce with oregano and basil extracts in obese children fatty on RCR. 61 were enrolled, 52 completed study. A randomized cross over clinical trial performed. Participants assigned RCR alone or supplement juice 60 days; subsequently, groups switched alternative next days. Reduction BMI, HOMA-IR,...