A5108003960- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Medical Imaging and Pathology Studies
- Myasthenia Gravis and Thymoma
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Infectious Diseases and Tuberculosis
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Occupational and environmental lung diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- HIV-related health complications and treatments
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
- Airway Management and Intubation Techniques
- Antibiotic Use and Resistance
- History of Medical Practice
- Veterinary medicine and infectious diseases
University of Naples Federico II
1990-2021
Ospedale San Paolo
2020
University of Milan
2020
Federico II University Hospital
2003-2016
University of Bologna
2009-2010
Ospedale Monaldi
2003-2008
UNESCO
2003-2005
University of Campania "Luigi Vanvitelli"
2003
Ospedale dei Bambini Vittore Buzzi
2003
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for existence multiple physiological functions this hormone rodents. In contrast, information regarding roles humans is limited. Three morbidly obese children, who were congenitally deficient leptin, treated with daily subcutaneous injections recombinant human up to 4 years sustained, beneficial effects on appetite, fat mass,...
The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for existence multiple physiological functions this hormone rodents. In contrast, information regarding roles humans is limited. Three morbidly obese children, who were congenitally deficient leptin, treated with daily subcutaneous injections recombinant human up to 4 years sustained, beneficial effects on appetite, fat mass,...
SUMMARY Clinical manifestations of pulmonary tuberculosis (TB) may depend on a complex interaction between the host and pathogen. outcomes are variable, ranging from asymptomatic lifelong infection to parenchymal lung destruction, resulting in cavitary lesions. To investigate hypothesis that local cellular immune response affect presentation outcome tuberculosis, we performed bronchoalveolar lavage (BAL) segments affected by non-cavitary tuberculosis. We then correlated type at level...
Abstract Glycogen storage disease type 1b (GSD-1b) is an autosomal-recessive caused by mutation of glucose-6–phosphate transporter and characterized altered glycogen/glucose homeostasis. A higher frequency autoimmune diseases has been observed in GSD-1b patients, but the molecular determinants leading to this phenomenon remain unknown. To address question, we investigated effect on immune cell homeostasis CD4+ T functions. In subjects, found lymphopenia a reduced capacity cells engage...
Rapid diagnostic tools for Helicobacter pylori are important in endoscopy.To assess the accuracy of a new 5 min rapid urease test (UFT300, ABS Srl, Cernusco sul Naviglio, Milan, Italy) and to compare it with 1 h Pyloritek (Serim Laboratories, Elkhart, IN, USA) 24 CLO (Kimberly-Clark Ballard Medical Products, Roswell, GA, USA).Consecutive dyspeptic patients referred our unit endoscopy were prospectively studied. All underwent (13)C-urea-breath test, histology UFT300 (ABS Srl; Italy). In...
The alveolar macrophage (AM), a major defense cell in the lung, participates immune and inflammatory reactions through release of several regulatory chemotactic cytokines. In particular, macrophages are considered to play pivotal proinflammatory role production maintenance airway inflammation bronchial hyperreactivity. To assess phenotypic pattern AM from asthmatic subjects, we performed following experiments: 1) cytofluorometric analysis specific features (CD11b, CD14, CD16, CD45, HLA-DR,...
Thymomas are rare tumours that sustain T-lymphopoiesis and trigger a variety of autoimmune diseases immunodeficiencies, including fatal hypogammaglobulinemia, namely Good's Syndrome (GS). Due to its rarity, GS has been poorly investigated immunological features, as well pathogenetic mechanisms underlying this syndrome, unclear. We studied 30 thymoma patients by performing an assessment, immunophenotype analysis T cell repertoire (TCR). Development was characterized progressive decrease in B,...
Idiopathic Pulmonary Fibrosis/ Usual Interstitial Pneumonia (IPF/UIP) represents the most important interstitial pneumonia. ATh2 cytokine pathway predominance, favoring collagen deposition, associated to a deficit in (IFN- gamma) network, seems be involved pathogenesis of this disease. Nonetheless, few data are available about potentially cells. Natural killer cells (NK), one subsets implicated IFN-gamma network. The aim study was assess NK cells, both BAL and peripheral blood 11 patients...
Bronchial hyperresponsiveness and airway infiltration with eosinophils T lymphocytes are key features of asthma. In particular, CD4 + cells currently believed to play a pivotal role as initiators coordinators the asthmatic inflammatory response and, therefore, they represent crucial target corticosteroid treatment. The aim present investigation is thus evaluate, in patients mild asthma, effects inhaled therapy on following parameters: (i) functional state cells; (ii) eosinophilia; (iii)...
<h3>Background</h3> Clarithromycin (CH) and metronidazole (MZ) are routinely used in <i>Helicobacter pylori</i> treatment regimes. Recently, with these antibiotics has been reported to fail >30% of patients due increasing resistance. The common chemosusceptibility methods cumbersome take up 14 days. Chemosusceptibility <i>H is therefore rarely checked. <h3>Aim</h3> To develop a rapid susceptibility test (RST) for pylori</i>. <h3>Methods</h3> Preliminary experiments were performed find...
Pulmonary alveolar microlithiasis (PAM) is a rare diffuse lung disease characterised by the accumulation of calcium phosphate microliths within alveoli. The causative mechanism PAM has only recently been discovered, and involves gene mutation sodium co-transporter, which expressed epithelial cells. This may have variable consequences on clinical phenotype. However, pulmonary cell immune phenotyping in familial not previously assessed. In present article, analysis bronchoalveolar lavage fluid...
Abstract CD4 + Foxp3 regulatory T cells (Tregs) are key to maintain peripheral self -tolerance and suppress immune responses tumors. Their accumulation in the tumor microenvironment (TME) correlates with poor clinical outcome several human cancers, including breast cancer (BC). However, properties of intratumoral Tregs remain largely unknown. Here, we found that a functionally distinct subpopulation tumor-infiltrating Tregs, which express splicing variant retaining exon 2 (Foxp3E2), is...