A5062100447- Multiple Sclerosis Research Studies
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Drug Transport and Resistance Mechanisms
- Hematological disorders and diagnostics
- Neurogenesis and neuroplasticity mechanisms
- Peripheral Neuropathies and Disorders
- Immunodeficiency and Autoimmune Disorders
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Neutropenia and Cancer Infections
- MicroRNA in disease regulation
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Olfactory and Sensory Function Studies
- Functional Brain Connectivity Studies
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Systemic Lupus Erythematosus Research
Istituto Neurologico Mediterraneo
2021-2025
University of Rome Tor Vergata
2009-2024
University of Messina
2018-2024
Center for Discovery
2024
University of Catania
2021
University of Pavia
2020
New York College of Podiatric Medicine
2017
University of Naples Federico II
2016
University of Campania "Luigi Vanvitelli"
2016
St. Eugenio Hospital
1993-2012
Background: Astrocytes and microglia play an important role in the inflammatory process of multiple sclerosis (MS). We investigated associations between cerebrospinal fluid (CSF) levels glial fibrillary acid protein (GFAP) soluble triggering receptors expressed on myeloid cells-2 (sTREM-2), molecules, clinical characteristics a group patients with relapsing-remitting MS (RRMS). Methods: Fifty-one RRMS participated study. Clinical evaluation CSF collection were performed at time diagnosis....
Experimental studies identified a role of neuroinflammation in the pathogenesis neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, inflammatory molecules as diagnostic and prognostic biomarkers patients with ALS is unclear. In this cross-sectional study, cerebrospinal fluid (CSF) levels set cytokines chemokines were analyzed 56 newly diagnosed 47 age- sex-matched control without or degenerative neurological disorders. The included: interleukin (IL)-1β, IL-2,...
Medical education is a time of high stress and anxiety for many graduate students in medical professions. In this study, we sought to investigate the effect academic on cortical excitability plasticity by using transcranial magnetic stimulation (TMS). We tested two groups (n = 13 each) healthy (mean age 33.7 ± 3.8 SE). One group was during final exam week (High-stress group) while other after break, without exams (Low-stress group). Students were required fill Perceived Stress Scale-10 (PSS)...
The endocannabinoid system (ECS) has been recently recognized as a prominent promoter of the emotional homeostasis, mediating effects different environmental signals including rewarding and stressing stimuli. ECS modulates stimuli, influencing synaptic transmission in dopaminergic projections to limbic system, mediates neurophysiological behavioral consequences stress. Notably, individual psychosocial context is another key element modulating activity ECS. Finally, inflammation represents an...
Background: Synaptic plasticity helps in reducing the clinical expression of brain damage and represents a useful mechanism to compensate negative impact new lesions multiple sclerosis (MS). Inflammation, altering synaptic plasticity, could negatively influence disease course relapsing-remitting MS (RR-MS). Objective: In present study, we explored whether interleukin (IL)-6, major proinflammatory cytokine involved pathogenesis, alters affects ability for ongoing damage. Methods: The effect...
The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention the field multiple sclerosis (MS) research but it still its infancy. In present study, we observed a large sample MS patients that let-7b-5p levels cerebrospinal fluid (CSF) were highly correlated with number implicated MS, as well variety inflammation-related protein factors, showing specific expression patterns coherent let-7b-5p-mediated regulation. Additionally, found CSF...
Exercise is increasingly recommended as a supportive therapy for people with Multiple Sclerosis (pwMS). While clinical research has still not disclosed the real benefits of exercise on MS disease, animal studies suggest substantial beneficial effect motor disability and pathological hallmarks such central peripheral dysregulated immune response. The hippocampus, core area memory formation learning, brain region involved in pathophysiology. Human rodent that hippocampus highly sensitive to...
Future treatments of multiple sclerosis (MS), a chronic autoimmune neurodegenerative disease the central nervous system (CNS), aim for simultaneous early targeting peripheral immune function and neuroinflammation. Sphingosine-1-phosphate (S1P) receptor modulators are among most promising drugs with both "immunological" "non-immunological" actions. Selective S1P have been recently approved MS shown clinical efficacy in its mouse model, experimental encephalomyelitis (EAE). Here, we...
Abstract Aim We recently proposed miR‐142‐3p as a molecular player in inflammatory synaptopathy, new pathogenic hallmark of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), that leads to neuronal loss independently demyelination. MiR‐142‐3p seems be unique among potential biomarker candidates MS, since it is an miRNA playing dual role the immune central nervous systems. Here, we aimed verify impact circulating cerebrospinal fluid (CSF) MS patients...
Multiple sclerosis (MS) is a progressive neurodegenerative disease of the central nervous system characterized by inflammation-driven synaptic abnormalities. Interleukin-9 (IL-9) emerging as pleiotropic cytokine involved in MS pathophysiology.
The clinical significance of the expression CD7 antigen on blasts 207 consecutive patients with de novo acute myeloid leukemia (AML) was evaluated. For this purpose, fifty-three CD7+ (23 females and 30 males; mean age 52 years) were analyzed classified into following subtypes according to French-American-British (FAB) classification: 7 M0, 13 M1, 9 M2, 1 M3, M4, 14 M5. Immunophenotypic studies carried out by flow cytometry blast cells selected basis forward light scatter gating pan-myeloid...