A5030430260- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- Biblical Studies and Interpretation
- HIV-related health complications and treatments
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Renal Transplantation Outcomes and Treatments
- Historical and Linguistic Studies
- HIV Research and Treatment
- Historical, Religious, and Philosophical Studies
- Cancer Immunotherapy and Biomarkers
- Archaeology and Historical Studies
- Liver Disease and Transplantation
- COVID-19 epidemiological studies
- Viral-associated cancers and disorders
- Antibiotic Use and Resistance
- Lymphoma Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
Policlinico San Matteo Fondazione
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of Pavia
2010-2023
Pharmacy Research UK
2020
Infectious Diseases and the Research Institute
2020
University of Bari Aldo Moro
1989-2015
Arud
2008
University of Insubria
2003
Hospital for Tropical Diseases
2002
Charleston Area Medical Center
1996
Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms ICU admission and mortality rate critically ill patients with severe COVID-19 pneumonia. Design: Patients pneumonia were prospectively enrolled SMAtteo COvid19 REgistry (SMACORE). A retrospective analysis treated TCZ matched using propensity score Standard Of Care (SOC) was conducted. Setting: The conducted at IRCCS Policlinico San Matteo Hospital, Pavia, Italy, from March 14, 2020 27, 2020. Participants: a...
Despite the progress in medical care, combined population-wide interventions (such as physical distancing, testing and contact tracing) are still crucial to manage SARS-CoV-2 pandemic, aggravated by emergence of new highly transmissible variants. We combine compartmental SIDARTHE model, predicting course COVID-19 infections, with a data-based model that projects cases onto casualties healthcare system costs. Based on Italian case study, we outline several scenarios: mass vaccination...
Metabolic syndrome is a cluster of risk factors, such as central obesity, dyslipidemia, glucose intolerance, hypertension, related to insulin resistance. In HIV patients resistance and several metabolic abnormalities the have been described, but few conflicting studies investigated behaviour blood pressure. The aims present study were evaluate prevalence hypertension in large group HIV-patients on highly active antiretroviral therapy (HAART) investigate relationship between resistance.Case...
<h3>Objective</h3> In patients with hepatitis C virus (HCV)/HIV co-infection, a faster progression of liver fibrosis to cirrhosis has been reported. this study, an investigation was carried out determine whether gp120, HIV envelope protein, modulates the biology human hepatic stellate cells (HSCs), key cell types in pathogenesis fibrosis. <h3>Methods</h3> Myofibroblastic HSCs were isolated from normal tissue. Gene expression measured by real-time PCR. Cell migration assessed Boyden chambers....
Objectives Metabolic syndrome is a cluster of risk factors, such as central obesity, dyslipidemia, glucose intolerance, hypertension, related to insulin resistance. In HIV patients resistance and several metabolic abnormalities the have been described, but few conflicting studies investigated behaviour blood pressure. The aims present study were evaluate prevalence hypertension in large group HIV-patients on highly active antiretroviral therapy (HAART) investigate relationship between Design...
The hyperinflammation phase of severe SARS-CoV-2 is characterised by complete blood count alterations. In this context, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) can be used as prognostic factors. We studied NLR PLR trends at different timepoints computed optimal cutoffs to predict four outcomes: use continuous positive airways pressure (CPAP), intensive care unit (ICU) admission, invasive ventilation death. retrospectively included all adult patients with...
The two available pegylated interferon formulations, peginterferon alpha-2a and alpha-2b, have different pharmacokinetic profiles; as a result they may differing abilities to suppress the hepatitis C virus. A recently reported study by Formann colleagues assessing early viral kinetics among 20 patients receiving alpha-2b either once or twice weekly suggests that once-weekly administration of is not sufficient for continuous exposure over 160 h. Twice-weekly recommended avoid increases in...
We studied the expression of PDGF-alpha and -beta receptors in 10 normal 40 pathologic human kidneys (five minimal change disease, five membranous nephropathy, 25 IgA lupus nephritis), by both immunohistochemistry situ hybridization techniques. In normal-appearing kidneys, were expressed at glomerular interstitial level, latter receptor more intensely than former. The distribution degree nonproliferative glomerulonephritides comparable with those found kidneys. PDGF-beta gene protein...
Abstract Background Protease inhibitors (PIs) to treat hepatitis C (HCV) virus infection have been approved and others are under development. Results The aims of this study were illustrate natural polymorphisms in the HCV protease measure frequency PI resistance mutations different genotypes from PI-naïve patients. Direct sequencing NS3/4A was performed 156 patients naïve PIs who infected with genotype 1a (n = 31), 1b 39), 2 30), 3 33) 4 23). Amino acid (aa) substitutions associated found...
Performance of Real-Time Strain Elastography, Transient and Aspartate-to-Platelet Ratio Index in the Assessment Fibrosis Chronic Hepatitis CGiovanna Ferraioli1, Carmine Tinelli2, Antonello Malfitano3, Barbara Dal Bello4, Gaetano Filice3, Carlo Filice1, Liver Study Group, Elisabetta Above1, Giorgio Barbarini3, Enrico Brunetti1, Willy Calderon3, Marta Di Gregorio1, Raffaella Lissandrin1, Serena Ludovisi3, Laura Maiocchi3, Giuseppe Michelone3, Mario Mondelli3, Savino F. A. Patruno3, Alessandro...
Abstract We studied 160 Hepatitis C virus (HCV)‐positive patients with NHL (59 indolent NHL, 101 aggressive). Median age was 67 years. HCV‐RNA present in 146. HBsAg positive seven patients. At diagnosis, ALT value above UNL One hundred and twenty received an anthracycline‐based therapy, alkylators, 28 chemotherapy plus rituximab. Cytotoxic drugs dose reduced 63 Among 93 normal at presentation, 16 developed WHO grade II–III liver toxicity. abnormal ALT, eight had a 3.5 times elevation during...
To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used a recently published meta-analysis.This was single center cross-sectional study. Consecutive chronic viral hepatitis scheduled for biopsy at the outpatient ward Infectious Diseases Department were enrolled. TE carried out using FibroScan™ (Echosens, Paris, France). Liver performed on same day as TE, case procedure. Fibrosis staged according to Metavir scoring...
To explore whether the use of four dimensional (4D) ultrasound examination with B-flow imaging and spatiotemporal image correlation (STIC) can supply additional information respect to two-dimensional (2D) gray-scale color Doppler echocardiography in prenatal characterization isolated total anomalous pulmonary venous connection (TAPVC).The study population comprised a group three TAPVC fetuses that had been examined exclusively by conventional echocardiography, cases initially identified...
Abstract An accurate prediction of the clinical outcomes European patients requiring hospitalisation for Coronavirus Disease 2019 (COVID-19) is lacking. The aim study to identify predictors in-hospital mortality and discharge in a cohort Lombardy with COVID-19. All consecutive hospitalised from February 21st March 30th, 2020, confirmed COVID-19 IRCCS Policlinico San Matteo, Pavia, Lombardy, Italy, were included. In-hospital evaluated by competing risk analysis. Fine Gray model was fitted...
We prospectively treated patients with hepatitis C virus (HCV)-associated indolent lymphomas genotype-appropriate direct-acting antivirals (DAAs) the aim to evaluate virologic and hematologic outcomes. No prospective studies in this setting have been published so far.FIL_BArT is a prospective, multicenter, phase II trial that evaluated DAAs untreated HCV-positive without criteria for immediate conventional antilymphoma treatment. The primary objective was sustained response, whereas main...