Paolo Sacchi

ORCID: 0000-0002-9679-0419
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Research Areas
  • Hepatitis C virus research
  • Hepatitis B Virus Studies
  • Liver Disease Diagnosis and Treatment
  • HIV/AIDS drug development and treatment
  • COVID-19 Clinical Research Studies
  • Biblical Studies and Interpretation
  • HIV-related health complications and treatments
  • COVID-19 and healthcare impacts
  • SARS-CoV-2 and COVID-19 Research
  • Systemic Lupus Erythematosus Research
  • Long-Term Effects of COVID-19
  • Renal Transplantation Outcomes and Treatments
  • Historical and Linguistic Studies
  • HIV Research and Treatment
  • Historical, Religious, and Philosophical Studies
  • Cancer Immunotherapy and Biomarkers
  • Archaeology and Historical Studies
  • Liver Disease and Transplantation
  • COVID-19 epidemiological studies
  • Viral-associated cancers and disorders
  • Antibiotic Use and Resistance
  • Lymphoma Diagnosis and Treatment
  • Hepatitis Viruses Studies and Epidemiology
  • Fungal Infections and Studies
  • Antifungal resistance and susceptibility

Policlinico San Matteo Fondazione
2016-2025

Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025

University of Pavia
2010-2023

Pharmacy Research UK
2020

Infectious Diseases and the Research Institute
2020

University of Bari Aldo Moro
1989-2015

Arud
2008

University of Insubria
2003

Hospital for Tropical Diseases
2002

Charleston Area Medical Center
1996

Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms ICU admission and mortality rate critically ill patients with severe COVID-19 pneumonia. Design: Patients pneumonia were prospectively enrolled SMAtteo COvid19 REgistry (SMACORE). A retrospective analysis treated TCZ matched using propensity score Standard Of Care (SOC) was conducted. Setting: The conducted at IRCCS Policlinico San Matteo Hospital, Pavia, Italy, from March 14, 2020 27, 2020. Participants: a...

10.3390/microorganisms8050695 article EN cc-by Microorganisms 2020-05-09

Despite the progress in medical care, combined population-wide interventions (such as physical distancing, testing and contact tracing) are still crucial to manage SARS-CoV-2 pandemic, aggravated by emergence of new highly transmissible variants. We combine compartmental SIDARTHE model, predicting course COVID-19 infections, with a data-based model that projects cases onto casualties healthcare system costs. Based on Italian case study, we outline several scenarios: mass vaccination...

10.1038/s41591-021-01334-5 article EN cc-by Nature Medicine 2021-04-16

Metabolic syndrome is a cluster of risk factors, such as central obesity, dyslipidemia, glucose intolerance, hypertension, related to insulin resistance. In HIV patients resistance and several metabolic abnormalities the have been described, but few conflicting studies investigated behaviour blood pressure. The aims present study were evaluate prevalence hypertension in large group HIV-patients on highly active antiretroviral therapy (HAART) investigate relationship between resistance.Case...

10.1097/01.hjh.0000059071.43904.dc article EN PubMed 2003-07-01

<h3>Objective</h3> In patients with hepatitis C virus (HCV)/HIV co-infection, a faster progression of liver fibrosis to cirrhosis has been reported. this study, an investigation was carried out determine whether gp120, HIV envelope protein, modulates the biology human hepatic stellate cells (HSCs), key cell types in pathogenesis fibrosis. <h3>Methods</h3> Myofibroblastic HSCs were isolated from normal tissue. Gene expression measured by real-time PCR. Cell migration assessed Boyden chambers....

10.1136/gut.2008.163287 article EN Gut 2009-09-07
Stefania Paolucci Irene Cassaniti Federica Novazzi L Fiorina Antonio Piralla and 95 more Giuditta Comolli Raffaele Bruno Renato Maserati Roberto Gulminetti Stefano Novati Francesco Mojoli Fausto Baldanti Raffaele Bruno Mario U. Mondelli Enrico Brunetti Angela Di Matteo Elena Seminari Laura Maiocchi Valentina Zuccaro Layla Pagnucco B Mariani Serena Ludovisi Raffaella Lissandrin Antonio Parisi Paolo Sacchi SFA Patruno G Michelone Roberto Gulminetti Domenico Zanaboni Stefano Novati Renato Maserati P Orsolini Marco Vecchia Marco Sciarra Erika Asperges Marta Colaneri Di Filippo A Margherita Sambo Simona Biscarini Matteo Lupi Silvia Roda T.C. Pieri Ilaria Gallazzi Michele Sachs P. Valsecchi Stefano Perlini C Alfano Marco Bonzano Domenica Federica Briganti Giuseppe Crescenzi A.G. Falchi Roberta Guarnone Barbara Katia Guglielmana Enrico Maggi Ilaria Martino Pietro Pettenazza Serena Pioli di Marco Francesca Maria Quaglia Anna Sabena Francesco Salinaro Francesco Speciale Ilaria Zunino M De Lorenzo Gioel Gabrio Secco L. Dimitry Giovanni Cappa Igor Maisak Benedetta Chiodi M. Sciarrini Bruno Barcella Flavia Resta Luca Moroni Giulia Vezzoni Lorenzo Scattaglia Enrico Boscolo Caterina Zattera MF Tassi Vincenzo Capozza Damiano Vignaroli Marco Bazzini Giorgio Antonio Iotti Francesco Mojoli Mirko Belliato Luciano Perotti Silvia Mongodi Guido Tavazzi Gian Luigi Marseglia Amelia Licari Ilaria Brambilla Daniela Barbarini Antonio Bruno Patrizia Cambieri Giulia Campanini C. Cavanna Giuditta Comolli Marta Corbella R. Daturi Milena Furione B Mariani P. Marone

10.1016/j.ijid.2020.12.051 article EN cc-by-nc-nd International Journal of Infectious Diseases 2020-12-21

Objectives Metabolic syndrome is a cluster of risk factors, such as central obesity, dyslipidemia, glucose intolerance, hypertension, related to insulin resistance. In HIV patients resistance and several metabolic abnormalities the have been described, but few conflicting studies investigated behaviour blood pressure. The aims present study were evaluate prevalence hypertension in large group HIV-patients on highly active antiretroviral therapy (HAART) investigate relationship between Design...

10.1097/00004872-200307000-00028 article EN Journal of Hypertension 2003-06-27

The hyperinflammation phase of severe SARS-CoV-2 is characterised by complete blood count alterations. In this context, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) can be used as prognostic factors. We studied NLR PLR trends at different timepoints computed optimal cutoffs to predict four outcomes: use continuous positive airways pressure (CPAP), intensive care unit (ICU) admission, invasive ventilation death. retrospectively included all adult patients with...

10.1007/s40121-023-00813-1 article EN cc-by-nc Infectious Diseases and Therapy 2023-05-17

The two available pegylated interferon formulations, peginterferon alpha-2a and alpha-2b, have different pharmacokinetic profiles; as a result they may differing abilities to suppress the hepatitis C virus. A recently reported study by Formann colleagues assessing early viral kinetics among 20 patients receiving alpha-2b either once or twice weekly suggests that once-weekly administration of is not sufficient for continuous exposure over 160 h. Twice-weekly recommended avoid increases in...

10.1177/135965350400900405 article EN Antiviral Therapy 2004-05-01

We studied the expression of PDGF-alpha and -beta receptors in 10 normal 40 pathologic human kidneys (five minimal change disease, five membranous nephropathy, 25 IgA lupus nephritis), by both immunohistochemistry situ hybridization techniques. In normal-appearing kidneys, were expressed at glomerular interstitial level, latter receptor more intensely than former. The distribution degree nonproliferative glomerulonephritides comparable with those found kidneys. PDGF-beta gene protein...

10.1172/jci117348 article EN Journal of Clinical Investigation 1994-07-01

Abstract Background Protease inhibitors (PIs) to treat hepatitis C (HCV) virus infection have been approved and others are under development. Results The aims of this study were illustrate natural polymorphisms in the HCV protease measure frequency PI resistance mutations different genotypes from PI-naïve patients. Direct sequencing NS3/4A was performed 156 patients naïve PIs who infected with genotype 1a (n = 31), 1b 39), 2 30), 3 33) 4 23). Amino acid (aa) substitutions associated found...

10.1186/1743-422x-9-245 article EN cc-by Virology Journal 2012-10-24

Performance of Real-Time Strain Elastography, Transient and Aspartate-to-Platelet Ratio Index in the Assessment Fibrosis Chronic Hepatitis CGiovanna Ferraioli1, Carmine Tinelli2, Antonello Malfitano3, Barbara Dal Bello4, Gaetano Filice3, Carlo Filice1, Liver Study Group, Elisabetta Above1, Giorgio Barbarini3, Enrico Brunetti1, Willy Calderon3, Marta Di Gregorio1, Raffaella Lissandrin1, Serena Ludovisi3, Laura Maiocchi3, Giuseppe Michelone3, Mario Mondelli3, Savino F. A. Patruno3, Alessandro...

10.2214/ajr.11.7517 article IT American Journal of Roentgenology 2012-06-27

Abstract We studied 160 Hepatitis C virus (HCV)‐positive patients with NHL (59 indolent NHL, 101 aggressive). Median age was 67 years. HCV‐RNA present in 146. HBsAg positive seven patients. At diagnosis, ALT value above UNL One hundred and twenty received an anthracycline‐based therapy, alkylators, 28 chemotherapy plus rituximab. Cytotoxic drugs dose reduced 63 Among 93 normal at presentation, 16 developed WHO grade II–III liver toxicity. abnormal ALT, eight had a 3.5 times elevation during...

10.1002/ajh.21564 article EN American Journal of Hematology 2009-10-14

To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used a recently published meta-analysis.This was single center cross-sectional study. Consecutive chronic viral hepatitis scheduled for biopsy at the outpatient ward Infectious Diseases Department were enrolled. TE carried out using FibroScan™ (Echosens, Paris, France). Liver performed on same day as TE, case procedure. Fibrosis staged according to Metavir scoring...

10.3748/wjg.v19.i1.49 article EN cc-by-nc World Journal of Gastroenterology 2013-01-01

To explore whether the use of four dimensional (4D) ultrasound examination with B-flow imaging and spatiotemporal image correlation (STIC) can supply additional information respect to two-dimensional (2D) gray-scale color Doppler echocardiography in prenatal characterization isolated total anomalous pulmonary venous connection (TAPVC).The study population comprised a group three TAPVC fetuses that had been examined exclusively by conventional echocardiography, cases initially identified...

10.1002/uog.5145 article EN Ultrasound in Obstetrics and Gynecology 2007-10-04

Abstract An accurate prediction of the clinical outcomes European patients requiring hospitalisation for Coronavirus Disease 2019 (COVID-19) is lacking. The aim study to identify predictors in-hospital mortality and discharge in a cohort Lombardy with COVID-19. All consecutive hospitalised from February 21st March 30th, 2020, confirmed COVID-19 IRCCS Policlinico San Matteo, Pavia, Lombardy, Italy, were included. In-hospital evaluated by competing risk analysis. Fine Gray model was fitted...

10.1038/s41598-020-80679-2 article EN cc-by Scientific Reports 2021-01-13

We prospectively treated patients with hepatitis C virus (HCV)-associated indolent lymphomas genotype-appropriate direct-acting antivirals (DAAs) the aim to evaluate virologic and hematologic outcomes. No prospective studies in this setting have been published so far.FIL_BArT is a prospective, multicenter, phase II trial that evaluated DAAs untreated HCV-positive without criteria for immediate conventional antilymphoma treatment. The primary objective was sustained response, whereas main...

10.1200/jco.22.00668 article EN cc-by-nc-nd Journal of Clinical Oncology 2022-06-17
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