A5022552300- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Hepatitis C virus research
- CNS Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Cutaneous lymphoproliferative disorders research
- Glycosylation and Glycoproteins Research
- Ovarian cancer diagnosis and treatment
- COVID-19 Clinical Research Studies
- Multiple Myeloma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- COVID-19 and healthcare impacts
- Genomic variations and chromosomal abnormalities
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
Policlinico San Matteo Fondazione
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of Pavia
2009-2024
Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen (12%) showed BCR; 7 86 (8%) retrieved databases also belonged to subsets. Three categories subsets were identified: i) "SMZL-specific subsets" (n=5), composed only 12 (9 HCV-from our series); ii) "Non-Hodgkin's lymphoma-like...
Summary This international retrospective study of 593 S plenic M arginal Z one L ymphoma ( SMZL ) patients aimed to identify factors that determine treatment initiation and influence lymphoma‐specific survival LSS ). Logistic regression was used the associated with treatment. A Cox analyse in a derivation cohort 366 patients. produced prognostic index PI enabled identification three risk groups. The resulting stratification validated another 227 compared Interguppo Italiano Linfomi IIL score...
Hepatitis C virus has been found to be associated with B-cell non-Hodgkin lymphomas, mostly marginal zone lymphomas and diffuse large lymphoma. Deregulation of signaling pathways involved in normal development (NOTCH pathway, NF-κB, BCR signaling) demonstrated splenic We studied mutations NOTCH pathway 46 patients hepatitis virus-positive lymphoma 64 unrelated HCV. NOTCH2 were detected 9 (20%) patients, NOTCH1 2 (4%). By contrast, only one HCV-negative had a or mutation. The frequency the...
A specific prognostication score for hepatitis C virus-positive diffuse large B-cell lymphomas is not available. For this purpose, the Fondazione Italiana Linfomi (FIL, Italian Lymphoma Foundation) carried out a multicenter retrospective study on consecutive series of patients with virus-associated lymphoma to evaluate prognostic impact clinical and virological features develop subset patients. All evaluations were performed 535 treated an anthracycline-based induction regimen (with...
BackgroundMarginal zone lymphomas (MZL), comprised of three unique but related subtypes, lack a unifying prognostic score applicable to all the patients in need for systemic chemotherapy and/or immunotherapy.MethodsPatients from prospective NF10 study (NCT02904577) with newly diagnosed MZL and receiving frontline therapy at diagnosis or after observation were used train model. The primary endpoint was progression-free survival (PFS) start treatment. model externally validated pooled analysis...
Abstract We studied 160 Hepatitis C virus (HCV)‐positive patients with NHL (59 indolent NHL, 101 aggressive). Median age was 67 years. HCV‐RNA present in 146. HBsAg positive seven patients. At diagnosis, ALT value above UNL One hundred and twenty received an anthracycline‐based therapy, alkylators, 28 chemotherapy plus rituximab. Cytotoxic drugs dose reduced 63 Among 93 normal at presentation, 16 developed WHO grade II–III liver toxicity. abnormal ALT, eight had a 3.5 times elevation during...
Categorization of primary cutaneous B-cell lymphomas (PCBCL) other than marginal zone (MZL) represents a diagnostic challenge with relevant prognostic implications. The 2008 WHO lymphoma classification recognizes only follicular center cell (PCFCCL) and diffuse large lymphoma, leg type (PCDLBCL-LT), whereas the previous 2005 WHO/EORTC also included an intermediate form, namely PCDLBCL, other. We conducted retrospective, multicentric, consensus-based revision clinicopathologic characteristics...
We prospectively treated patients with hepatitis C virus (HCV)-associated indolent lymphomas genotype-appropriate direct-acting antivirals (DAAs) the aim to evaluate virologic and hematologic outcomes. No prospective studies in this setting have been published so far.FIL_BArT is a prospective, multicenter, phase II trial that evaluated DAAs untreated HCV-positive without criteria for immediate conventional antilymphoma treatment. The primary objective was sustained response, whereas main...
Follicular lymphoma is the most frequent low-grade in western countries, accounting for 25% of all cases (Tan & Horning, 2008). Although follicular generally considered a long lasting indolent disorder, survival duration heterogeneous and precise prognostic evaluation Rituximab era greatly needed (Johnston Salles, The Lymphoma International Prognostic Index (FLIPI) was developed from retrospective series collaborative international working party (Solal-Celigny et al, 2004) validated...