A5055040350- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Diabetes Management and Research
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Cystic Fibrosis Research Advances
- Immunodeficiency and Autoimmune Disorders
- Parathyroid Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Antimicrobial Resistance in Staphylococcus
- Chronic Disease Management Strategies
- Galectins and Cancer Biology
- Growth Hormone and Insulin-like Growth Factors
- interferon and immune responses
- Systemic Sclerosis and Related Diseases
- Cardiovascular Disease and Adiposity
- Cutaneous lymphoproliferative disorders research
Universidad Europea
2016-2025
Hospital Universitario Quirónsalud Madrid
2016-2025
Hospital Quirónsalud Barcelona
2020-2023
Hospital Ruber Internacional
2017-2019
Hospital Quirón Torrevieja
2015
Hospital Universitario Príncipe de Asturias
2014
Hospital Universitario Ramón y Cajal
2010-2013
Instituto Ramón y Cajal de Investigación Sanitaria
2012
Yahoo (United Kingdom)
2009
The purpose of this study is to characterize the risk cancer in a large cohort patients with primary Sjögren syndrome (SjS).We had analyzed development 1300 consecutive fulfilling 2002 SjS classification criteria. baseline clinical and immunological characteristics systemic activity (ESSDAI scores) were assessed at diagnosis as predictors using Cox proportional hazards regression analysis adjusted for age gender. sex-and age-specific standardized incidence ratios (SIR) estimated from 2012...
Abstract Background Advanced age is a well-known risk factor for poor prognosis in COVID-19. However, few studies have specifically focused on very old inpatients with This study aims to describe the clinical characteristics of COVID-19 and identify factors in-hospital mortality at admission. Methods We conducted nationwide, multicenter, retrospective, observational patients ≥ 80 years hospitalized 150 Spanish hospitals (SEMI-COVID-19) Registry (March 1–May 29, 2020). The primary outcome was...
Dalbavancin is a lipoglycopeptide with potent activity against Gram-positive microorganisms, long half-life, favorable safety profile, and high concentration in bone, which makes it an interesting alternative for treatment of osteoarticular infections. We performed multicentric retrospective study all patients infection (septic arthritis, spondylodiscitis, osteomyelitis, or orthopedic implant-related infection) treated at least one dose dalbavancin between 2016 2017 30 institutions Spain.
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that plitidepsin distributes preferentially to lung over plasma, with similar potency against across several variants in preclinical studies. Simultaneously, this randomized, parallel, open-label, proof-of-concept study (NCT04382066) conducted 10 Spanish hospitals between May and November 2020, 46...
Summary This international retrospective study of 593 S plenic M arginal Z one L ymphoma ( SMZL ) patients aimed to identify factors that determine treatment initiation and influence lymphoma‐specific survival LSS ). Logistic regression was used the associated with treatment. A Cox analyse in a derivation cohort 366 patients. produced prognostic index PI enabled identification three risk groups. The resulting stratification validated another 227 compared Interguppo Italiano Linfomi IIL score...
Patients with advanced chronic kidney disease (CKD) exhibit higher prevalence of coronary artery calcification (CaC) than general population. CaC has been proposed as a risk factor for mortality in end-stage CKD, but most studies the field are based on short-term follow-up.We conducted cohort, 10-year prospective longitudinal study consecutive cases referred to renal unit. A non-enhanced multislice computed tomography was performed at baseline. assessed by Agatston method. were stratified...
Our aim in this work is to find biomarkers optimize therapy with IL-6 inhibitors, as not all clinical trials have shown clear benefits on mortality or mechanical ventilation progression. Given the link between delayed seroconversion and higher complication risks, we test if evaluating SARS-CoV-2 spike protein antibody status before treatment could enhance inhibitor effectiveness COVID-19 patients. We conducted a post hoc analysis of COVACTA study, phase 3, randomized, double-blind,...
(1) Background: Large cohort studies of patients with COVID-19 treated remdesivir have reported improved clinical outcomes, but data on older are scarce. Objective: This work aims to assess the potential benefit in unvaccinated very old hospitalized COVID-19; (2) Methods: is a retrospective analysis ≥ 80 years Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences 30-day all-cause mortality were adjusted using multivariable regression analysis. (3) Results: Of 4331...
Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with disease 2019 (COVID-19). NEPTUNO, III, multicenter, randomized, controlled trial, designed to evaluate the efficacy safety plitidepsin management moderate COVID-19 adult patients.
Interstitial lung disease (ILD) is a frequent manifestation of Sjögren's syndrome (SS), an autoimmune salivary and lacrimal glands, affects approximately 20% patients. No clinical or serological features appear to be useful predict its presence, severity progression, chest high-resolution computed tomography (CT) remains the gold standard for diagnosis. Semiquantitative CT (SQCT) based on visual assessment (Goh Taouli scoring) can estimate ILD extent, although it burdened by relevant intra-...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in December 2019 as the cause of severe pneumonia a cluster patients Wuhan, China. Subsequently, this viral pathogen described novel RNA betacoronavirus [1]. As with other members its group, SARS-CoV-2 is able to syndrome, case named disease (COVID-19).
We aim to describe the safety and efficacy of sotrovimab in severe cases COVID-19 immunocompromised hosts.We used a retrospective multicenter cohort including hospitalized patients with treated between October 2021 December 2021.We included 32 patients. The main immunocompromising conditions were solid organ transplantation (46.9%) hematological malignancy (37.5%). Seven (21.9%) had respiratory progression: 12.5% died 9.4% required mechanical ventilation. Patients within first 14 days their...
To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS.We searched for SS presenting (defined following according to European Centre Disease Prevention Control guidelines) among those included Big Data Sjögren Registry, an international, multicentre registry diagnosed 2002/2016 classification criteria.A total 51 were study (46 women, mean age at diagnosis 60 years). According number evaluated Registry (n = 8211), estimated frequency was 0.62% (95% CI 0.44,...
The International Prognostic Score (IPS) is the most widely used system to date for identifying risk groups outcome of patients with advanced Hodgkin lymphoma, although important limitations have been recognized. We analyzed value IPS in a series 311 classical lymphoma (cHL) (Ann Arbor stage III, IV or II B symptoms and/or bulky masses) treated first-line chemotherapy including adriamycin (adriamycin, bleomycin, vinblastine, dacarbazine [ABVD] equivalent variants). In univariate and...