A5049546065- Pharmaceutical Practices and Patient Outcomes
- Antibiotic Use and Resistance
- Patient Safety and Medication Errors
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Surgical site infection prevention
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Electronic Health Records Systems
- Central Venous Catheters and Hemodialysis
- Medication Adherence and Compliance
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant Pathogens and Fungal Diseases
- Clostridium difficile and Clostridium perfringens research
- Safe Handling of Antineoplastic Drugs
- Orthopedic Infections and Treatments
- Nosocomial Infections in ICU
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Long-Term Effects of COVID-19
- Patient Satisfaction in Healthcare
- HIV-related health complications and treatments
- Pharmacovigilance and Adverse Drug Reactions
Hospital General Universitario Gregorio Marañón
2015-2025
Comunidad de Madrid
2022
Universidad Complutense de Madrid
2019
Collaborative Group (United States)
2017
Abstract Background There is a paucity of knowledge on the long-term outcome in patients diagnosed with COVID-19. We describe cohort constellation symptoms occurring four weeks after diagnosis causing different degrees reduced functional capacity. Although hypothesis have been proposed to explain this condition like persistent immune activation or immunological dysfunction, date, no physiopathological mechanism has identified. Consequently, there are therapeutic options besides symptomatic...
In a patient on immunosuppressant treatment, SARS-CoV-2 RNA was documented in different extra-respiratory samples over several months the absence of positive determinations upper respiratory samples. Whole-genome sequencing these showed acquisition single-nucleotide polymorphisms time, suggesting viral evolution and thus viability.
To identify the frequency of medication administration errors and their potential risk factors in units using a computerized prescription order entry program profiled automated dispensing cabinets.Prospective observational study conducted within two clinical Gastroenterology Department 1537-bed tertiary teaching hospital Madrid (Spain).Medication were measured disguised observation technique. Types severity described. The correlation between was studied to causes.In total, 2314...
Implementation of robotic systems in outpatient hospital pharmacies is uncommon. Other than cost, 1 the barriers to widespread adoption lack definitive evidence that this technology actually reduces dispensing errors and improves inventory management.To identify frequency medication before after implementation a original pack system an pharmacy analyse impact on quality stock management staff satisfaction.A prospective before-and-after error study was performed using disguised observation...
To critically evaluate the causes of preventable adverse drug events during nurse medication administration process in inpatient units with computerized prescription order entry and profiled automated dispensing cabinets to prioritize interventions that need be implemented impact specific on criticality index.This is a failure mode, effects analysis (FMECA) study. A multidisciplinary consensus committee composed pharmacists, nurses doctors evaluated administering medications hospital setting...
Background People living with human immunodeficiency virus (HIV) require specific pharmaceutical care (PC). Although the 2017 Capacity-Motivation-Opportunity (CMO) PC model allows a multidisciplinary approach that focuses on patient needs, it is too complex and presents room for improvement. Objective The aim of this study to simplify adapt previous tool through multidimensional improve HIV care, prove validity in real-life patients. Methods new was generated by keeping some variables...
Oritavancin (ORT) is a new single-dose lipoglycopeptide showing in vitro activity against staphylococci and vancomycin-resistant enterococci. However, there no data regarding its potential use as catheter lock solution are scarce. We constructed an model to analyze the efficacy stability of ORT biofilm enterococci over 7 days at 37 °C. used Staphylococcus aureus, epidermidis, vancomycin-susceptible Enterococcus faecalis ATCC strains. performed metabolic assay using 2-mg/ml 7-day incubation...
Background Clinical decision support systems (CDSSs) are a good strategy for preventing medication errors and reducing the incidence severity of adverse drug events (ADEs). However, these not very effective subject to multiple limitations that prevent their implementation in clinical practice. Objectives The objective this study was evaluate effectiveness an advanced CDSS, HIGEA, which generates alerts based on predefined rules identify patients at risk ADE. Methods A multidisciplinary team...
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have emerged as a therapeutic option for patients with hypercholesterolemia who do not attain low-density lipoprotein cholesterol (LDL-C) goals and/or are intolerant to other lipid-lowering drugs. Our aim was analyze the effectiveness and safety of PCSK9i in routine clinical practice factors related poor outcomes.We conducted an ambispective study 115 recieved alirocumab or evolocumab, tertiary level hospital. From February...
We aimed to describe the frequency of use and effectiveness bezlotoxumab (BZX) fecal microbiota transplantation (FMT) in patients with Clostridioides difficile infection (CDI) real-world practice.This was a retrospective study conducted university hospital which adult treated BZX or FMT from January 2018 April 2021 were included. The primary objective evaluate preventing early (within 8 weeks) late 1 year) CDI recurrences (rCDI). A multivariate analysis risk factors for recurrence...
Mould-active prophylaxis is affecting the epidemiology of invasive mycoses in form a shift toward less common entities such as fusariosis. We analyze characteristics fusariosis and its association to antifungal retrospective cohort (2004-2017) from tertiary hospital Madrid, Spain. Epidemiological, clinical, microbiological, consumption data were retrieved. Isolates identified molecular level, susceptibility was tested. Eight cases diagnosed. Three periods according incidence: <2008 (three...
Dalbavancin is an antibiotic with activity against gram-positive bacteria that allows early discharge of patients requiring intravenous therapy. Outpatient treatment helps offset hospitalisation costs associated standard treatment. Our objective was to assess the cost disease management, including dalbavancin, in a Spanish hospital for 1 year, and hypothetical other therapeutic alternatives dalbavancin.A single-centre, observational, retrospective post-hoc analysis conducted based on...
The implementation of 1,3 β-d-glucan (BDG) has been proposed as a diagnostic tool in antifungal stewardship programs (ASPs). We aimed to analyze the influence serum BDG an ASP for oncologic patients and solid organ transplant (SOT) recipients. conducted pre–post study. In initial period (PRE), was based on bedside advice, this complemented with post-period (POST). Performance parameters assay were determined. Antifungal (AF) use adequacy evaluated using point score. Clinical outcomes AF...
<h3>Objectives</h3> Infection following orthopaedic surgery is a feared complication and an indicator of the quality hospital. Surgical antibiotic prophylaxis (SAP) guidelines are not always properly followed. Our aim was to describe evaluate impact multidisciplinary intervention on adherence hospital 30-day postoperative outcomes. <h3>Methods</h3> The study carried out from January May 2016 consisted creating team, updating institutional embedding recommendations in computerised physician...
A failure modes, effects and criticality analysis was supported by an observational medication error rate study to analyze the impact of Phocus Rx ® , a new image-based workflow software system, on chemotherapy compounding rates. Residual risks that should be target for additional action were identified prioritized pharmacy staff satisfaction with system evaluated. In total, 16 potential modes recognized in pre-implementation phase 21 after implementation. The total reduction index 67...
We previously demonstrated the efficacy of a frozen dalbavancin-heparin (DH) lock solution against biofilms staphylococci. However, as enterococci also commonly cause catheter-related bloodstream infections (C-RBSI), we assessed bioactivity dalbavancin (D) and DH enterococci. Over 6 months, compared (1 mg/ml) with that D in terms cfu counts metabolic activity Enterococcus faecalis faecium (four strains each). For each solution, individually results obtained at time point (months 3 6)...