A5001203920- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Pediatric health and respiratory diseases
- Infections and bacterial resistance
- Antimicrobial Resistance in Staphylococcus
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Infectious Diseases and Mycology
- Medical Imaging and Pathology Studies
- Nosocomial Infections in ICU
- Dysphagia Assessment and Management
- Infant Nutrition and Health
- Tuberculosis Research and Epidemiology
- Plant Pathogenic Bacteria Studies
- Respiratory viral infections research
Hospital Universitario Ramón y Cajal
2016-2025
Universidad de Alcalá
1998-2025
Hospital Universitario del Henares
2024
Canadian Respiratory Research Network
2023
Instituto Cajal
2013-2022
Instituto de Salud Carlos III
2022
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022
Instituto Ramón y Cajal de Investigación Sanitaria
2011-2021
Services Hospital
2013
Masaryk University
2010
Bronchiectasis is a multidimensional disease and, therefore, its severity or prognosis cannot be adequately quantified by analysing one single variable. The objective of the present study was to develop score that classifies bronchiectasis according prognosis. This an observational multicentre including 819 patients diagnosed with non-cystic fibrosis using high-resolution computed tomography. 397 subjects were selected at random construct while remaining 422 used for validation. outcome...
COPD and bronchiectasis are commonly reported together. Studies report varying impacts of co-diagnosis on outcomes, which may be related to different definitions disease used across studies.
Background A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In European Bronchiectasis Registry (EMBARC), we tested whether would associated with disease severity and clinical outcomes. Methods We a prospective, observational registry adults conducted 31 countries. Patients who did not produce spontaneous were excluded from analysis. The Murray was at baseline follow-up visits. Key outcomes frequency...
Asthma is commonly reported in patients with a diagnosis of bronchiectasis.
Patients with bronchiectasis (BE) present exacerbations that increase severity of the disease. We aimed to determine annual cost BE treatment according its severity, determined by FACED score, as well parameters associated higher costs. Multicentre historical cohorts study patients from six hospitals in Spain. The costs arising during course a year maintenance treatment, exacerbations, emergency visits and hospital admissions were analysed. In total, 456 included (56.4% mild BE, 26.8%...
Data on the prevalence of and factors associated with nontuberculous mycobacteria (NTM) in patients non–cystic fibrosis (CF) bronchiectasis are limited. Our aim was to determine isolation NTM this population. We performed a multicenter observational study historical cohorts comprising consecutive non-CF at least 2 sputum samples cultured for over period 5 years. The population included 218 adult (61.9 % women) mean (SD) age 55.7 (16) years 5.1 (3.3) cultures/patient. isolated from 18 (8.3...
To evaluate insulin-secretion kinetics and insulin sensitivity in cystic fibrosis (CF) patients with normal glucose tolerance (CF-NGT), impaired (CF-IGT) or CF-related diabetes (CFRD), the potential effects of moderate hyperglycemia on clinical nutritional status.Cross-sectional study including 50 outpatients CF. Patients underwent both oral (OGGT) intravenous (IVGTT) tests order to assess secretion peripheral sensitivity. Homeostasis assessment model OGGT were used investigate Forced...
Cystic fibrosis (CF) lung microbiota composition has recently been redefined by the application of next-generation sequencing (NGS) tools, identifying, among others, previously undescribed anaerobic and uncultivable bacteria. In present study, we monitored fluctuations this ecosystem in 15 CF patients during a 1-year follow-up period, describing for first time, as far know, presence predator bacteria microbiome. addition, new computational model was developed to ascertain hypothetical...