A5059844925- Laser Applications in Dentistry and Medicine
- Medical and Biological Ozone Research
- Multiple Sclerosis Research Studies
- Bee Products Chemical Analysis
- Photodynamic Therapy Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Dietary Effects on Health
- Olfactory and Sensory Function Studies
- Infrared Thermography in Medicine
- Circadian rhythm and melatonin
- Hydrogen's biological and therapeutic effects
- Liver physiology and pathology
- Inflammation biomarkers and pathways
- Cancer, Lipids, and Metabolism
- Skin Protection and Aging
- Metabolism, Diabetes, and Cancer
- Parasite Biology and Host Interactions
- Helminth infection and control
- Organ Transplantation Techniques and Outcomes
- Parasites and Host Interactions
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
Washington University in St. Louis
2023-2025
University of Wisconsin–Milwaukee
2013-2024
Fundação Oswaldo Cruz
2006
Universidade Salvador
2001
Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests daily and intermittent CR (iCR) people with MS (pwMS) showed improvements fatigue well-being measures. This trial studied the effects 12-week iCR on metabolic, immunological, clinical outcomes pwMS.
Background: Photobiomodulation (PBM) therapy was previously shown to reduce the clinical severity of disease and modulated pro- anti-inflammatory cytokines in an animal model multiple sclerosis (MS). Objective: Previous observations were extended determine effect PBM on peripheral blood mononuclear cells CD4+ T isolated from persons with MS (PwMS) healthy donors. Methods: Using vitro cell culture system, activated treated red or near-infrared light wavelengths production interferon gamma...
Septal fibrosis is a common form of hepatic fibrosis, but its etiology and pathogenesis are poorly understood. Rats infected with the helminth Capillaria hepatica constitute good experimental model such fibrosis. To investigate pathogenetic contribution several parasitic factors involved, following procedures were performed in rats: a) regarding role eggs, these isolated injected either into peritoneal cavity or directly liver parenchyma; b) for worms alone, 15-day-old infection was treated...
Background: Multiple sclerosis (MS) is a neurodegenerative condition characterized by high concentration of nitric oxide leading to the production reactive oxygen species (ROS) and nitrogen (RNS), known as nitrosative stress. ROS RNS produce inhibition mitochondrial electron transport chain dysfunction, reduction adenosine triphosphate, death neurons, producing severe irreversible damage in central nervous system people with MS (PwMS). Current drug treatments for focus on regulation immune...
Abstract Multiple sclerosis (MS) is a CD4+ Th1/Th17 mediated autoimmune disease characterized by myelin destruction, neurodegeneration and mitochondrial dysfunction. Current therapies suppress inflammation during early stages but are not effective in chronic oxidative damage. New to slow progression, offer neuroprotection, ameliorate the symptoms at any stage urgently needed. Photobiomodulation therapy (PBMT) with light 600–1100 nm demonstrated improve inflammatory neurodegenerative...
ABSTRACT Background Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) through reduction inflammation. The aim this trial was to study the effects 12-week iCR on metabolic, immunological and clinical outcomes in people with MS (pwMS). Methods Participants relapsing-remitting were randomly assigned intermittent CR (iCR) or a control group for 12 weeks. Primary outcome change leptin levels; secondary included changes anthropometric body composition measures,...
Abstract Multiple sclerosis (MS) is an autoimmune disease characterized by myelin destruction, neurodegeneration and mitochondrial dysfunction. High production of nitric oxide (NO) iNOS contributes to the generation reactive nitrogen species, leading increased nitrosative stress dysfunction linked MS progression. Current therapies focus on suppression immune system in early stages, but they are not effective chronic stages where takes control over pathogenic mechanisms. Thus, new that reduce...
Muscle weakness and fatigue are two disabling symptoms of Multiple Sclerosis (MS). Photobiomodulation therapy (PBMT) using red/near-infrared light is an emerging therapeutic modality thought to improve endurance or strength in healthy populations. Previously presented work revealed that a single acute high energy dose PBMT may muscle force recovery persons with MS (PwMS). PURPOSE: To investigate the effect extended at optimal on during fatiguing contraction PwMS. METHODS: Randomized...
Abstract BACKGROUND: Intermittent calorie restriction (iCR) reduces inflammation in preclinical models and people with Multiple Sclerosis (pwMS). Mechanisms could be related to changes levels of adipose tissue-derived adipokines reduced systemic gut microbiota composition. AIMS: Evaluate the effects iCR on levels, metabolic immune/inflammatory biomarkers compared a control unrestricted diet (Ctr) pwMS. METHODS: PwMS (relapsing Remitting MS) were randomly assigned or Ctr groups for 12 weeks....
Symptomatic fatigue, as well muscle are common in persons with multiple sclerosis (PwMS), and both can negatively affect quality of life (QOL). Photobiomodulation Therapy (PBMT), comprising light a 600-1000 nm bandwidth, is an emerging therapeutic modality thought to enhance mitochondrial function. There evidence that PBMT improve inflammation, psychological status thus might be beneficial for PwMS. PURPOSE: To investigate on force recovery after fatiguing contraction A secondary aim was...