Raphaël Duivenvoorden
A5063763204- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- COVID-19 and healthcare impacts
- Immune cells in cancer
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Dialysis and Renal Disease Management
- COVID-19 Impact on Reproduction
- Renal Diseases and Glomerulopathies
- Long-Term Effects of COVID-19
- Healthcare cost, quality, practices
- Coronary Interventions and Diagnostics
- Immunotherapy and Immune Responses
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 and COVID-19 Research
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
Icahn School of Medicine at Mount Sinai
2014-2025
Radboud University Medical Center
2019-2025
University Medical Center
2021-2025
Radboud University Nijmegen
2010-2025
Radboud Institute for Molecular Life Sciences
2019-2021
Amsterdam UMC Location University of Amsterdam
2010-2021
University of Amsterdam
2008-2021
Amsterdam University Medical Centers
2018-2021
Imaging Center
2018
New York University
2014
Abstract Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed transplant dialysis patients with COVID-19. For analysis, were included who presented...
Abstract Diabetes, hypertension and cardiovascular disease have been listed as risk factors for severe coronavirus 2019 (COVID-19) since the first report of in January 2020. However, this did not mention chronic kidney (CKD) nor it provide information on relevance estimated glomerular filtration rate (eGFR) or albuminuria. As spread across globe, larger populations with greater granularity emerged. The recently published OpenSAFELY project analysed associated COVID-19 death 17 million...
Nanoparticle-based delivery of simvastatin inhibits plaque macrophage proliferation in apolipoprotein E–deficient mice.
Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but can result in immune suppression. The authors recently identified small molecule inhibitors that block interaction between CD40 and tumor necrosis factor receptor-associated (TRAF) 6 (TRAF-STOPs), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.This study evaluates potential of TRAF-STOP treatment atherosclerosis.The effects TRAF-STOPs on atherosclerosis were investigated...
Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT), an intracellular enzyme involved in cholesterol accumulation, with pactimibe was developed to assist the prevention cardiovascular disease.To evaluate efficacy and safety inhibition atherosclerosis.A prospective, randomized, stratified, double-blind, placebo-controlled study (Carotid Atherosclerosis Progression Trial Investigating Vascular ACAT Treatment Effects [CAPTIVATE]) 892 patients heterozygous for familial...
Abstract A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery anti-tumour agents. The drug–carrier association after intravenous administration essential efficient drug the tumour. However, a large number currently available nanocarriers are self-assembled whose drug-loading stability critically affected by in vivo environment. Here we used FRET imaging systematically investigate how compatibility affects release tumour mouse model. We found drug’s...
Reports suggest a role of endothelial dysfunction and loss barrier function in COVID-19. It is well established that the glycocalyx-degrading enzyme heparanase contributes to vascular leakage inflammation. Low molecular weight heparins (LMWH) serve as an inhibitor heparanase. We hypothesize pathogenesis COVID-19, may be inhibited by LMWH. To test this hypothesis, activity heparan sulfate levels were measured plasma healthy controls (n = 10) COVID-19 patients 48). Plasma significantly...
Immunological complexity in atherosclerosis warrants targeted treatment of specific inflammatory cells that aggravate the disease. With initiation large phase III trials investigating immunomodulatory drugs for atherosclerosis, cardiovascular disease enters a new era. We here propose radically different approach: implementing and evaluating vivo combinatorial library nanoparticles with distinct physiochemical properties differential immune cell specificities. The library's are based on...
Macrophages play a central role in the pathogenesis of atherosclerosis. The inflammatory properties these cells are dictated by their metabolism, which mechanistic target rapamycin (mTOR) signaling pathway is key regulator. Using myeloid cell-specific nanobiologics apolipoprotein E-deficient (Apoe-/-) mice, we found that targeting mTOR and ribosomal protein S6 kinase-1 (S6K1) pathways rapidly diminished plaque macrophages' activity. By investigating transcriptome modifications, identified...
A nanoimmunotherapy reduces inflammation in mouse, rabbit, and pig models of atherosclerosis.
Background and aimsInfusion of high-density lipoprotein (HDL) mimetics aimed at reducing atherosclerotic burden has led to equivocal results, which may relate in part the inability HDL adequately reach lesions humans. This study evaluated delivery recombinant human apolipoprotein A-I (apoA-I) containing mimetic CER-001 carotid plaques patients.MethodsCER-001 was radiolabeled with long-lived positron emitter zirconium-89 (89Zr) enable emission tomography computed (PET/CT) imaging. Eight...
Abstract Regulating innate immunity is an emerging approach to improve cancer immunotherapy. Such regulation requires engaging myeloid cells by delivering immunomodulatory compounds hematopoietic organs, including the spleen. Here we present a polymersome-based nanocarrier with splenic avidity and propensity for red pulp cell uptake. We characterized in vivo behaviour of four chemically identical yet topologically different polymersomes positron emission tomography imaging innovative flow...
Our aim was to compare common carotid mean wall thickness (MWT) measurements by 3.0-T MRI with B-mode ultrasound intima-media (CCIMT) measurements, a validated surrogate marker for cardiovascular disease.B-mode and scans of the left right arteries were repeated 3 times in 15 healthy younger volunteers (age, 26+/-2.6 years), older 57+/-3.2 subjects disease atherosclerosis 63+/-9.8 years). MWT 0.711 (SD, 0.229) mm CCIMT 0.800 0.206) mm. highly correlated (r=0.89, P<0.001). The intraclass...