Azam Nurmohamed
A5042410023- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Healthcare cost, quality, practices
- COVID-19 Clinical Research Studies
- Telemedicine and Telehealth Implementation
- Healthcare Systems and Technology
- COVID-19 and healthcare impacts
- Renal Diseases and Glomerulopathies
- Organ and Tissue Transplantation Research
- Medication Adherence and Compliance
- Cytomegalovirus and herpesvirus research
- Liver Disease and Transplantation
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Pancreatitis Pathology and Treatment
- Digital Mental Health Interventions
- Transplantation: Methods and Outcomes
- Long-Term Effects of COVID-19
- Biomedical Research and Pathophysiology
- Systemic Lupus Erythematosus Research
- Cardiac pacing and defibrillation studies
- Chronic Kidney Disease and Diabetes
Amsterdam University Medical Centers
2021-2025
University of Amsterdam
2021-2023
Vrije Universiteit Amsterdam
2018-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2022
Netherlands Heart Registration
2016
Vanderbilt University Medical Center
2014
Abstract Background. Patients on kidney replacement therapy comprise a vulnerable population and may be at increased risk of death from coronavirus disease 2019 (COVID-19). Currently, only limited data are available outcomes in this patient population. Methods. We set up the ERACODA (European Renal Association COVID-19 Database) database, which is specifically designed to prospectively collect detailed transplant dialysis patients with COVID-19. For analysis, were included who presented...
BackgroundHistopathological assessment of transplant biopsies is currently the standard method to diagnose allograft rejection and can help guide patient management, but it one most challenging areas pathology, requiring considerable expertise, time, effort. We aimed analyse utility deep learning preclassify histology kidney into three main broad categories (ie, normal, rejection, other diseases) as a potential biopsy triage system focusing on rejection.MethodsWe performed retrospective,...
Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about replacement therapy (KRT) strategy during the pandemic. This study investigated association of type KRT with COVID-19 severity, adjusting for differences in individual characteristics.
An increasing number of elderly patients (≥65 years) receive a donor kidney from donors after brain death (DBD) or circulatory (DCD). These organs are allocated within the Eurotransplant Senior Program, but outcomes must be evaluated. From Dutch Organ Transplantation Registry, we selected 3597 recipients (≥18 who received first DBD DCD during 2002-2012, and categorized them as young receiving graft either donor, stratified by type. In multiple logistic regression analysis, kidneys...
Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for reliable tool to define permissible in We previously demonstrated that donor-derived Predicted Indirectly ReCognizable Epitopes presented by recipient class II (PIRCHE-II) play role de novo DSA formation In the present Dutch multi-center study we evaluated possible association between PIRCHE-II and failure 2,918 donor-recipient couples were transplanted 1995 2005....
Despite growing waiting lists for renal transplants, hesitations persist with regard to the use of deceased after cardiac death (DCD) grafts. We evaluated outcomes DCD donations in The Netherlands, country highest proportion procedures (42.9%) test whether these are justified.This study included all grafts donated brain (DBD) (n = 3611) and 2711) performed between 2000 2017. Transplant were compared by Kaplan Meier Cox regression analysis, factors associated short (within 90 days...
In patients with type 1 diabetes and end-stage renal disease, it is controversial whether a simultaneous pancreas-kidney (SPK) transplantation improves survival compared kidney alone. We long-term in SPK living- or deceased-donor transplant recipients.We included all 2,796 the Netherlands who started replacement therapy between 1986 2016. used multivariable Cox regression analyses adjusted for recipient age sex, dialysis modality vintage, era, donor to compare all-cause mortality deceased-...
Abstract Background and hypothesis In search for controlled access to expensive innovative orphan drugs, a national route called “Orphan Drug Access Protocol” (ODAP) was developed piloted with lumasiran, new drug patients primary hyperoxaluria type 1 (PH1). Here, we present two-year evaluation of this pilot study. Methods Specialists from the Dutch PH1 Expert Centre ODAP steering group protocol conditional treatment children adults lumasiran. Indication is based on specific clinical...
In Brief Background Organ shortage persists despite a high rate of donation after circulatory death (DCD) in the Netherlands. The median waiting time for deceased donor kidney 2013 was 3.5 years. Most DCD kidneys are from controlled (cDCD; Maastricht category III). Experience with uncontrolled donors cardiac (uDCD), that is, an unexpected and irreversible arrest (Maastricht categories I II), is increasing; its effect on transplant outcomes needs evaluation. Methods We used Dutch...
The use of kidneys donated after circulatory death (DCD) remains controversial due to concerns with regard high incidences early graft loss, delayed function (DGF), and impaired survival. As these are mainly based on data from historical cohorts, they prone time-related effects may therefore not apply the current timeframe. To assess impact time outcomes, we performed a time-dependent comparative analysis outcomes DCD donation brain (DBD) kidney transplantations. Data all 11,415...
Objectives The adoption and subsequent implementation of telemonitoring across university hospital settings is a challenging task. This study provides insight into the perceived value using nationwide network to support scaling up in hospitals. Methods A qualitative approach was used evaluate role National eHealth ‘Citrien programme Implementation Upscaling (Citrien-2)’. In phase 1, an inventory questionnaire identify successes lessons learnt. Phase 2 consisted semi-structured group...
Delayed graft function (DGF) is a common complication after kidney transplantation in the era of accepting an equal number brain- and circulatory-death donor kidneys Netherlands. To identify those cases with increased risk developing DGF, various multivariable algorithms have been proposed. The objective was to validate reproducibility four predictive by Irish et al. (A prediction model for delayed current deceased renal transplantation. Am J Transplant 2010;10:2279-2286) (USA), Jeldres...
An accurate estimated glomerular filtration rate (eGFR) is essential in drug dosing. This study demonstrates the limitations of indexed (ml/min/1.73 m
Coronavirus disease 2019 (COVID-19)-related short-term mortality is high in dialysis patients, but longer-term outcomes are largely unknown. We therefore assessed patient recovery a large cohort of patients 3 months after their COVID-19 diagnosis.We analyzed data on diagnosed with from 1 February 2020 to 31 March 2021 the European Renal Association Database (ERACODA). The studied were survival, residence and functional mental health status (estimated by treating physician) diagnosis....
CD4 + T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well cellular responses, which might lead to failure of the allograft. memory from a previous immunizing event can potentially be reactivated exposure HLA mismatches that share T-cell epitopes with initial HLA. Consequently, reactivity toward are shared between and donor could increase risk alloimmunity transplantation, thus affecting transplant outcome. In this study,...
Abstract Solid‐phase multiplex‐bead assays are widely used in transplantation to detect anti‐human leukocyte antigen ( HLA ) antibodies. These enable high resolution detection of low levels However, costly and yield variable measurements that limit the comparison results between laboratories. In context a Dutch national Consortium study we aimed determine inter‐assay inter‐machine variability assays, assessed how reduce assay reagents costs. Fifteen sera containing variety antibodies were...
Kidney transplant candidates are blood group incompatible with roughly one out of three potential living donors. We compared outcomes after ABO-incompatible (ABOi) kidney transplantation matched ABO-compatible (ABOc) and deceased donor analyzed different induction regimens. performed a retrospective study propensity matching patient death-censored graft survival ABOi versus ABOc in nationwide registry from 2006 till 2019. 296 were 1184 center propensity-matched recipients (matching:...
Donor-characteristics and donor characteristics-based decision algorithms are being progressively used in the process whether or not to accept an available kidney graft for transplantation. While this may improve outcomes, performance characteristics of remains moderate. To estimate impact factors grafts accepted transplantation on transplant test implementation donor-characteristics-based clinical decision-making is justified, we applied instrumental variable analysis outcomes pairs...
The Dutch university medical centres (UMC's) are on the forefront when it comes to validation, implementation and research of telemonitoring. To aid UMC's in their effort, Government has supported by fostering 'Citrien eHealth program'. This program aims at nationwide upscaling telemonitoring via a collaborative network. quantify success this program, study provide insights into current adoption health care professionals (HCP) within UMC's.
Abstract Background Several guidelines recommend using the Clinical Frailty Scale (CFS) for triage of critically ill coronavirus disease 2019 (COVID-19) patients. This study evaluates impact CFS on intensive care unit (ICU) admission rate and hospital ICU mortality rates in hospitalized dialysis patients with COVID-19. Methods We analysed data diagnosed COVID-19 from European Renal Association Database. The primary outcome was secondary outcomes were until 3 months after diagnosis. Cox...
Previously we established a prediction model for graft intolerance syndrome requiring nephrectomy in patients with late kidney failure. The aim of this study is to determine generalizability an independent cohort. validation cohort included failure between 2008 and 2018. Primary outcome the prognostic performance our model, expressed as area under receiver operating characteristic curve (ROC-AUC), In 63 580 (10.9%) was performed because intolerance. original which donor age, survival number...