A5075327554- Thermoregulation and physiological responses
- Diabetes Management and Research
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Diabetes and associated disorders
- Systemic Sclerosis and Related Diseases
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Pancreatic function and diabetes
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Clinical practice guidelines implementation
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacology and Obesity Treatment
- Nutritional Studies and Diet
- Ovarian function and disorders
- Retinal Imaging and Analysis
University of Amsterdam
2023-2025
Amsterdam University Medical Centers
2018-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2011-2024
Bohn Stafleu van Loghum (Netherlands)
2019-2024
Geneeskundige en Gezondheidsdienst
2019-2024
Vrije Universiteit Amsterdam
2004-2023
Leiden University Medical Center
2023
University Medical Center Utrecht
2023
Public Health Service of Amsterdam
2023
General Department of Preventive Medicine
2007-2019
Background— Obesity is associated with an increased risk of developing microangiopathy, hypertension, and insulin resistance. We hypothesized that obesity a primary cause microvascular dysfunction, which may contribute to the development these obesity-related disorders. Methods Results— examined function in 16 lean (body mass index <24 kg/m 2 ) 12 obese >30 healthy women (mean age, 38.9±6.7 years) basal state during physiological systemic hyperinsulinemia. determined skin capillary...
Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical benefit in cancer patients. It is assumed that drugs, such as bevacizumab, transiently normalize abnormal tumor vasculature and contribute to improved delivery of subsequent chemotherapy. To investigate this concept, a study was performed non-small cell lung (NSCLC) patients using positron emission tomography (PET) radiolabeled docetaxel ([11C]docetaxel). In NSCLC, bevacizumab reduced both perfusion net...
Capillary rarefaction occurs in many tissues patients with essential hypertension and may contribute to an increased vascular resistance impaired muscle metabolism. Rarefaction be caused by a structural (anatomic) absence of capillaries, functional nonperfusion, or both. The aim this study was assess the extent versus capillary skin subjects hypertension. We examined density video microscopy before during maximization number perfused capillaries venous congestion (structural number)...
To investigate whether microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and function, we investigated individuals with increased coronary heart disease (CHD) risk.Forty-six healthy White aged 30-70 years were studied. Coronary was assessed use of CHD score according Framingham Heart Study, which based on age, blood pressure, cigarette smoking, total cholesterol, HDL cholesterol diabetes. Endothelium-dependent -independent...
Background —A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking to pressure. To test this hypothesis, we studied 18 normotensive glucose-tolerant subjects showing wide range in as assessed with the hyperinsulinemic, euglycemic clamp technique. Methods Results —Blood was measured by 24-hour ambulatory monitoring. Videomicroscopy used measure skin capillary...
To test the hypothesis that free fatty acids (FFAs) modulate microvascular function and this contributes to obesity-associated insulin resistance, hypertension, microangiopathy, we examined effects of both FFA elevation in lean women lowering obese on skin function. A total 16 12 underwent, respectively, Intralipid plus heparin (or saline) infusion overnight acipimox placebo) treatment. We measured capillary recruitment with capillaroscopy endothelium-(in)dependent vasodilation by...
The aim of this study was to investigate whether there are differences in capillary nailfold changes patients with systemic sclerosis (SSc) and without pulmonary arterial hypertension (PAH), these associated PAH severity disease specificity.Capillary density loop dimensions were studied 21 healthy controls, 20 idiopathic (IPAH) 40 SSc. Of the SSc, 19 had no (SSc-nonPAH) (SSc-PAH), whom eight during exercise.Capillary lower SSc-PAH compared who SSc-nonPAH (4.33/mm vs 6.56/mm respectively, p =...
Microvascular recruitment in muscle is a determinant of insulin sensitivity. Whether perivascular adipose tissue (PVAT) involved disturbed insulin-induced vasoreactivity unknown, as are the underlying mechanisms. This study investigates whether PVAT regulates vasodilation muscle, mechanisms, and how obesity disturbs this vasodilation. Insulin-induced resistance arteries was studied with from C57BL/6 or db/db mice. weight higher mice compared uncovered vasodilation; abrogated Blocking...
It has been proposed that insulin-mediated changes in muscle perfusion modulate glucose uptake. However, the putative effects of insulin on microcirculation permit such modulation have not studied humans. We examined systemic hyperinsulinemia skin microvascular function eight healthy nondiabetic subjects. In addition, locally administered blood flow were assessed 10 During a hyperinsulinemic clamp, we measured leg with venous occlusion plethysmography, capillary density capillaroscopy,...
Objective. Preliminary evidence suggests that ankylosing spondylitis (AS) is associated with an increased cardiovascular (CV) risk. We investigated subclinical atherosclerosis and arterial stiffness in patients AS compared controls, identified CV related risk factors for atherosclerotic disease. Methods. A total of 59 who were scheduled etanercept treatment according to the ASsessments Ankylosing Spondylitis guidelines 30 healthy controls recruited. Subclinical was assessed as average...
Ankylosing spondylitis (AS) is associated with increased cardiovascular morbidity and mortality. Microvascular function has been linked to several risk factors for disease. Inflammation in AS may cause microvascular dysfunction. To test this, we assessed (a) patients compared healthy controls (b) before after 1 month of anti-tumour necrosis factor (TNF)alpha treatment etanercept.A total 15 consecutive AS, who were scheduled etanercept according the Assessment Spondylitis (ASAS) group...
Please cite this paper as : Meijer RI, de Boer MP, Groen MR, Eringa EC, Rattigan S, Barrett EJ, Smulders YM, Serne EH. Insulin‐induced microvascular recruitment in skin and muscle are related both associated with whole‐body glucose uptake. Microcirculation 19 494–500, 2012. Abstract Objective: capillary is considered a determinant of insulin‐mediated Insulin action on the microvasculature has been assessed skin; however, there concern to whether vascular responses observed reflect those...
Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid leads to cognitive impairment dementia. To design AD prevention trials key include cognitively normal subjects at high risk for find predictors of decline these subjects. These goals be accomplished targeting twins, with additional benefits identify genetic environmental pathways pathology, other biomarkers, decline.From December 2014...
Abstract Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) lower blood pressure (BP). When SGLT2i GLP-1RA are combined, synergistic effects on BP have been observed. The mechanisms underlying these reductions incompletely understood. aim of this study was to assess the reduction with dapagliflozin, exenatide, dapagliflozin-exenatide compared placebo in people obesity type 2 diabetes. Methods Sixty-six diabetes were...
Objective: In patients with essential hypertension, defects in both the metabolic and vascular actions of insulin have been described. Impaired microvascular function, a well-established abnormality may explain part these defects. present study we investigated whether function is impaired hypertension relates to insulin's vasodilatatory actions. Methods: We measured 24-h ambulatory blood pressure, capillary recruitment after arterial occlusion, skin flow responses iontophoresis acetylcholine...