A5023581145- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Lung Cancer Treatments and Mutations
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Rheumatoid Arthritis Research and Therapies
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- S100 Proteins and Annexins
- Lung Cancer Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Bone and Joint Diseases
- Epilepsy research and treatment
- HER2/EGFR in Cancer Research
- Medical Imaging and Pathology Studies
- Heterotopic Ossification and Related Conditions
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2025
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2008-2025
Dutch Cancer Society
2023-2025
Cancer Center Amsterdam
2020-2025
Amsterdam Neuroscience
2014-2023
University of Geneva
2019-2023
General Electric (Spain)
2023
University College London
2019-2023
Amyloidosis Foundation
2023
Standardized uptake values (SUV) are commonly used for quantification of whole-body [18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies. Changes in SUV following therapy, however, only provide a proper measure response case homogeneous FDG the tumour. The purpose this study was therefore to implement and characterize method that enables heterogeneity tumour uptake. Cumulative SUV-volume histograms (CSH), describing % total volume above threshold maximum (SUVmax),...
The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements β-amyloid-1–42 (Aβ<sub>1-42</sub>) and total tau <sup>11</sup>C-Pittsburgh compound B (<sup>11</sup>C-PiB) 2-(1-{6-[(2-<sup>18</sup>F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile (<sup>18</sup>F-FDDNP) binding as measured using PET. <b>Methods:</b> A 37 subjects were included, consisting 15 patients with Alzheimer disease (AD), 12 mild cognitive...
Several methods are in use for analyzing <sup>11</sup>C-Pittsburgh compound-B (<sup>11</sup>C-PiB) data. The objective of this study was to identify the method choice measuring longitudinal changes specific <sup>11</sup>C-PiB binding. <b>Methods:</b> Dynamic 90-min baseline and follow-up scans (interval, 30 ± 5 mo) were obtained 7 Alzheimer disease (AD) patients, 11 patients with mild cognitive impairment (MCI), healthy controls. Parametric images generated using reference parametric mapping...
Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification dynamic (R)-[(11)C]PK11195 brain positron emission tomography (PET) studies. Reference tissues were extracted from images using both a manually defined cerebellum and SVCA based on either four (SVCA4) or six (SVCA6) kinetic classes. Data controls, mild cognitive impairment patients, patients with Alzheimer's disease analyzed various models including...
The objective of this study was to explore the feasibility harmonising performance for PET/CT systems equipped with time-of-flight (ToF) and resolution modelling/point spread function (PSF) technologies. A second aim producing a working prototype new criteria higher contrast recoveries than current EARL standards using various SUV metrics.Four both ToF PSF capabilities from three major vendors were used acquire reconstruct images NEMA NU2-2007 body phantom filled conforming EANM guidelines....
Previous studies have evaluated the diagnostic effect of amyloid positron emission tomography (PET) in selected research cohorts. However, these populations do not reflect daily practice, thus hampering clinical implementation imaging.To evaluate association PET with changes diagnosis, confidence, treatment, and patients' experiences an unselected memory clinic cohort.Amyloid using fluoride-18 florbetaben was offered to 866 patients who visited tertiary at VU University Medical Center...
Background/aims As a protrusion from the brain, retina might reflect status of brain. Previous studies showed decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) individuals suffering Alzheimer’s disease (AD). This study aims to assess whether such changes are already present preclinical stages AD, population monozygotic (MZ) twins. Methods 124 cognitively healthy (MZ twins, ages 60–93 years) underwent [ 18 F]flutemetamol...
To evaluate whether, in patients with non-small cell lung carcinoma (NSCLC), tumor uptake of [(11)C]erlotinib can be quantified and imaged using positron emission tomography to assess whether the level tracer corresponds presence activating EGF receptor (EGFR) mutations.Ten NSCLCs, five an EGFR exon 19 deletion, without were scanned twice (test retest) on same day interval at least 4 hours. Each scanning procedure included a low-dose computed tomographic scan, 10-minute dynamic [(15)O]H(2)O...
Abstract Background Surgical resection and irradiation of diffuse glioma are guided by standard MRI: T2/fluid attenuated inversion recovery (FLAIR)–weighted MRI for non-enhancing T1-weighted gadolinium-enhanced (T1G) enhancing gliomas. Amino acid PET has been suggested as the new standard. Imaging combinations may improve amino PET. The aim study was to determine accuracy imaging detect infiltration. Methods We included 20 consecutive adults with newly diagnosed (7 astrocytomas, isocitrate...
<h3>Objective</h3> To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. <h3>Methods</h3> Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 Alzheimer disease [AD] dementia, 111 non-AD 28 missing diagnosis) from 6 cohorts (European Medical Information Framework AD, Alzheimer9s Family, Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3,...
The Brain Imaging Data Structure (BIDS) is a standard for organizing and describing neuroimaging datasets, serving not only to facilitate the process of data sharing aggregation, but also simplify application development new methods software working with data. Here, we present an extension BIDS include positron emission tomography (PET) data, known as PET-BIDS, share several open-access datasets curated following PET-BIDS along tools conversion, validation analysis datasets.
To support clinical trial designs focused on early interventions, our study determined reliable amyloid-β (Aβ) accumulation based Centiloids (CL) in pre-dementia populations. A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease-Prognostic and Natural History Study (AMYPAD-PNHS) Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid-PET were included. normative strategy was used define by estimating 95th percentile longitudinal...
<sup>11</sup>C-Pittsburgh Compound-B (<sup>11</sup>C-PIB) and <sup>18</sup>F-(2-(1-{6-[(2-[<sup>18</sup>F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) (<sup>18</sup>F-FDDNP) have been developed as PET tracers for in vivo imaging of pathology Alzheimer9s disease (AD). The purpose this study was to directly compare these patients with AD, mild cognitive impairment (MCI), healthy controls. <b>Methods:</b> Paired <sup>11</sup>C-PIB <sup>18</sup>F-FDDNP scans were acquired 14 11 amnestic...
Delineation of tumour boundaries is important for quantification [(18)F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies and definition biological target volumes in radiotherapy. Several (semi-)automatic delineation methods have been proposed, but these differ substantially estimating volume their performance may be affected by imaging parameters. The main purpose this study was to explore the dependence various on different parameters, i.e. reconstruction noise...
We examined putative microglial activation as a function of illness course in schizophrenia. Microglial activity was quantified using [
Over the past decades, positron emission tomography (PET) imaging has become an increasingly useful research modality in field of multiple sclerosis (MS) research, as PET can visualise molecular processes, such neuroinflammation, vivo. The second generation radioligand [18F]DPA714 binds with high affinity to 18-kDa translocator-protein (TSPO), which is mainly expressed on activated microglia. aim this proof concept study was evaluate vivo marker neuroinflammation primary and secondary...
Evidence is accumulating that immune dysfunction involved in the pathophysiology of schizophrenia. It has been hypothesized microglia activation present patients with Various vivo and post-mortem studies have investigated this hypothesis, but as yet inconclusive results. Microglia associated elevations 18 kDa translocator protein (TSPO) levels, which can be measured positron emission tomography (PET) tracer (R)-[(11)C]PK11195. The purpose study was to investigate psychosis at an early stage...
It is a growing concern that outcomes of neuroimaging studies often cannot be replicated. To counteract this, the magnetic resonance (MR) community has promoted acquisition standards and created data sharing platforms, based on consensus how to organize share MR data. Here, we take similar approach positron emission tomography (PET) facilitate comparison findings across studies, first recommend publication for tracer characteristics, image acquisition, preprocessing, outcome estimation PET...
Amyloid pathology is the pathological hallmark in Alzheimer's disease (AD) and can precede clinical dementia by decades. So far it remains unclear how amyloid leads to cognitive impairment dementia. To design AD prevention trials key include cognitively normal subjects at high risk for find predictors of decline these subjects. These goals be accomplished targeting twins, with additional benefits identify genetic environmental pathways pathology, other biomarkers, decline.From December 2014...
<h3>Objective</h3> To apply the ATN scheme to memory clinic patients, assess whether it discriminates patient populations with specific features. <h3>Methods</h3> We included 305 patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild impairment [MCI]: 68 68% 48% dementia: 66 10 58% M) classified for positivity (±) of amyloid (A) ([<sup>18</sup>F]Florbetaben PET), tau (T) (CSF p-tau), and neurodegeneration (N) (medial temporal lobe atrophy). assessed profiles9...
Abstract Non-invasive imaging of arthritis activity in rheumatoid (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with tracer ( R )-[ 11 C]PK11195 were encouraging, but the signal could be further improved by reduction background uptake. Recently, novel [ 18 F]fluoro-PEG-folate was developed. This showed excellent targeting folate receptor β on activated macrophages synovial tissue a preclinical arthritic...