A5083325645- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Advanced Radiotherapy Techniques
- AI in cancer detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Thyroid Cancer Diagnosis and Treatment
- Radiation Detection and Scintillator Technologies
- Cancer, Hypoxia, and Metabolism
- Nuclear Physics and Applications
- Gastric Cancer Management and Outcomes
- Muscle metabolism and nutrition
- Machine Learning in Materials Science
- Sarcoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Additive Manufacturing and 3D Printing Technologies
- Radioactive Decay and Measurement Techniques
- Robotics and Automated Systems
- Robotic Locomotion and Control
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
Leiden University Medical Center
2016-2025
Leiden University
2019-2025
University Hospital Carl Gustav Carus
2020
OncoRay
2020
Helmholtz-Zentrum Dresden-Rossendorf
2020
Johns Hopkins University
2020
Technische Universität Dresden
2020
German Cancer Research Center
2020
National Center for Tumor Diseases
2020
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007-2016
The image biomarker standardisation initiative (IBSI) is an independent international collaboration which works towards standardising the extraction of biomarkers from acquired imaging for purpose high-throughput quantitative analysis (radiomics). Lack reproducibility and validation studies considered to be a major challenge field. Part this lies in scantiness consensus-based guidelines definitions process translating into biomarkers. IBSI therefore seeks provide nomenclature definitions,...
The ECAT high resolution research tomograph (HRRT) is a dedicated brain and small animal PET scanner, with design features that enable image spatial combined sensitivity. HRRT the first commercially available scanner utilizes double layer of LSO/LYSO crystals to achieve photon detection depth-of-interaction information. In this study, performance commercial was characterized, using NEMA protocol as guideline. Besides measurement resolution, energy sensitivity, scatter fraction, count rate...
To assess (1) the repeatability and (2) impact of reconstruction methods delineation on 105 radiomic features in non-small-cell lung cancer (NSCLC) 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomorgraphy/computed tomography (PET/CT) studies. Eleven NSCLC patients received two baseline whole-body PET/CT scans. Each scan was reconstructed twice, once using point spread function (PSF) complying with European Association for Nuclear Medicine (EANM) guidelines tumor PET imaging....
Standardized uptake values (SUV) are commonly used for quantification of whole-body [18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies. Changes in SUV following therapy, however, only provide a proper measure response case homogeneous FDG the tumour. The purpose this study was therefore to implement and characterize method that enables heterogeneity tumour uptake. Cumulative SUV-volume histograms (CSH), describing % total volume above threshold maximum (SUVmax),...
Quantitative accuracy of positron emission tomography (PET) is affected by partial volume effects resulting in increased underestimation the standardized uptake value (SUV) with decreasing tumour volume. The purpose present study was to assess and precision different correction (PVC) methods. Three methods for PVC were evaluated: (1) inclusion point spread function (PSF) within reconstruction, (2) iterative deconvolution PET images (3) calculation spill-in spill-out factors based on masks....
Abstract Objective Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with varying survival outcomes. This study investigated whether baseline PSMA PET/CT parameters are associated and treatment response. Methods Sixty mCRPC patients underwent [ 18 F]PSMA-1007 before androgen receptor-targeted agents (ARTAs) or chemotherapy. Intensity-based parameters, volumetric metastatic sites DmaxVox (distance between the two outermost voxels) from were collected, as well...
In addition to tumor size measurements with CT, there is a need for quantitative of metabolic active volumes, possibly adding tracer uptake in oncologic response evaluation PET. The aim this study was evaluate the volume test-retest variability (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET studies various commonly used volumes interest (VOIs) dependence that on lesion relative radiotracer uptake.Twenty non-small cell lung cancer patients were scanned twice (n = 11) or...
Delineation of tumour boundaries is important for quantification [(18)F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) studies and definition biological target volumes in radiotherapy. Several (semi-)automatic delineation methods have been proposed, but these differ substantially estimating volume their performance may be affected by imaging parameters. The main purpose this study was to explore the dependence various on different parameters, i.e. reconstruction noise...
To evaluate the feasibility and repeatability of various metabolically active tumor volume ( MATV ) quantification methods in fluorine 18 fluorodeoxyglucose FDG positron emission tomography (PET)/computed (CT) a multicenter setting propose optimal method together with minimal threshold for future response evaluation studies.The study was approved by institutional review board all four participating centers, patients provided written informed consent. Thirty-four advanced gastrointestinal...
The sensitivity of radiomic features to several confounding factors, such as reconstruction settings, makes clinical use challenging. To investigate the impact harmonized image reconstructions on feature consistency, a multicenter phantom study was performed using 3-dimensionally printed inserts reflecting realistic tumor shapes and heterogeneity uptakes. Methods: Tumors extracted from real PET/CT scans patients with non-small cell lung cancer served model for three inserts. Different...
Absolute quantification of radiotracer distribution using SPECT/CT imaging is great importance for dosimetry aimed at personalized radionuclide precision treatment. However, its accuracy depends on many factors. Using phantom measurements, this multi-vendor and multi-center study evaluates the quantitative inter-system variability various systems as well effect patient size, processing software reconstruction algorithms recovery coefficients (RC).Five were included: Discovery™ NM/CT 670 Pro...
Abstract Objectives Head and neck squamous cell carcinoma (HNSCC) shows a remarkable heterogeneity between tumors, which may be captured by variety of quantitative features extracted from diagnostic images, termed radiomics. The aim this study was to develop validate MRI-based radiomic prognostic models in oral oropharyngeal cancer. Materials Methods Native T1-weighted images four independent, retrospective (2005–2013), patient cohorts ( n = 102, 76, 89, 56) were used delineate primary...
Abstract Background Quantitative SPECT imaging in targeted radionuclide therapy with lutetium-177 holds great potential for individualized treatment based on dose assessment. The establishment of dose-effect relations requires a standardized method quantification. purpose this multi-center study is to evaluate quantitative accuracy and inter-system variations different SPECT/CT systems corresponding commercially available reconstruction algorithms. This an important step towards...
While brown adipose tissue (BAT) is activated by the beta-3-adrenergic receptor (ADRB3) in rodents, human adipocytes, ADRB2 dominantly present and responsible for noradrenergic activation. Therefore, we performed a randomized double-blinded crossover trial young lean men to compare effects of single intravenous bolus agonist salbutamol without with ADRB1/2 antagonist propranolol on glucose uptake BAT, assessed dynamic 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography-computed...
Abstract Background Positron emission tomography (PET) may be useful for defining the gross tumour volume radiation treatment planning and response monitoring of non-small cell lung cancer (NSCLC) patients. The purpose this study was to compare sizes obtained from CT- various more commonly available PET-based delineation methods pathology findings. Methods Retrospective non-respiratory gated whole body [ 18 F]-fluoro-2-deoxy-D-glucose PET/CT studies 19 NSCLC patients were used. Several...
PET can be used to monitor response during chemotherapy and assess biologic target volumes for radiotherapy. Previous simulation studies have shown that the performance of various automatic or semiautomatic tumor delineation methods depends on image characteristics. The purpose this study was test-retest variability methods, with emphasis effects several characteristics (e.g., resolution contrast).Baseline data from 19 non-small cell lung cancer patients were obtained using (18)F-FDG (n =...
The aim of this study was to assess radiomics features on pre-treatment [18F]FDG positron emission tomography (PET) as potential biomarkers for response and survival in patients with metastatic colorectal cancer (mCRC).Patients mCRC underwent PET/computed (CT) prior first- or third-line palliative systemic treatment. Tumour lesions were semiautomatically delineated standard uptake value (SUV), metabolically active tumour volume (MATV), total lesion glycolysis (TLG), entropy, area under the...
Abstract Human brown adipose tissue (BAT) is commonly assessed by cold-induced 18 F-fluorodeoxyglucose (FDG) PET-CT using several quantification criteria. Uniform criteria for data analysis became available recently (BARCIST 1.0). We compared BAT volume and activity following BARCIST 1.0 against the most used [Hounsfield Units (HU):-250, -50, standardized uptake value (SUV):2.0; HU: Not applied, SUV:2.0 HU:-180, -10, SUV:1.5] in a prospective study three independent cohorts of men including...
Aims/hypothesisBrown adipose tissue (BAT) improves energy metabolism by combusting glucose and lipids into heat. Agonism of the glucagon-like peptide-1 receptor (GLP-1R) within central nervous system activates BAT in mice. Moreover, patients with type 2 diabetes, GLP-1R agonism lowers body weight lipid levels, possibly involving activation. Interestingly, people from South Asian descent are prone to develop cardiometabolic disease. We studied effect on humans, specifically Asians Europids...
Abstract Purpose In order to achieve comparability of image quality, harmonisation PET system performance is imperative. this study, prototype criteria for brain studies were developed. Methods Twelve clinical PET/CT systems (4 GE, 4 Philips, Siemens, including SiPM-based “digital” systems) used acquire 30-min scans a Hoffman 3D Brain phantom filled with ~ 33 kBq·mL −1 [ 18 F]FDG. Scan data reconstructed using various reconstruction settings. The images rigidly coregistered template (voxel...
Abstract Purpose To evaluate whether quantitative [ 18 F]FDG-PET/CT assessment, including radiomic analysis of F]FDG-positive thyroid nodules, improved the preoperative differentiation indeterminate nodules non-Hürthle cell and Hürthle cytology. Methods Prospectively included patients with a Bethesda III or IV nodule underwent imaging. Receiver operating characteristic (ROC) curve was performed for standardised uptake values (SUV) SUV-ratios, assessment SUV cut-offs at which...
This study investigated whether radiomic features extracted from pretreatment [<sup>18</sup>F]FDG PET could improve the prediction of both histopathologic tumor response and survival in patients with locally advanced cervical cancer (LACC) treated neoadjuvant chemoradiotherapy followed by surgery compared conventional parameters features. <b>Methods:</b> The medical records all consecutive LACC referred between July 2010 2016 were reviewed. PET/CT was performed before chemoradiotherapy....
The high-resolution research tomograph (HRRT) is a dedicated human brain PET scanner. purpose of this study was to compare the quantitative accuracy HRRT with that clinical HR+ scanner and assess effects differences in spatial resolution between both scanners (∼2.7 mm ∼7.0 for HR+, respectively). <b>Methods:</b> Paired <sup>11</sup>C-flumazenil scans 7 healthy volunteers were assessed. For each volunteer, dynamic (including arterial sampling) acquired on same day, thereby minimizing...
Positron emission tomography data are typically reconstructed with maximum likelihood expectation maximization (MLEM). However, MLEM suffers from positive bias due to the non-negativity constraint. This is particularly problematic for tracer kinetic modeling. Two reconstruction methods reduction properties that do not use strict Poisson optimization presented and compared each other, filtered backprojection (FBP), MLEM. The first method an extension of NEGML, where distribution replaced by a...