A5077403448- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- FOXO transcription factor regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related gene regulation
- Gene expression and cancer classification
- HER2/EGFR in Cancer Research
- Genomic variations and chromosomal abnormalities
- Peptidase Inhibition and Analysis
- Genomics and Chromatin Dynamics
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Oral and Maxillofacial Pathology
- Esophageal Cancer Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
Vrije Universiteit Amsterdam
2010-2025
Amsterdam University Medical Centers
2018-2025
Cancer Center Amsterdam
2011-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2025
Erasmus MC
2024
MRC Holland (Netherlands)
2024
The Netherlands Cancer Institute
1998-2023
Dutch Cancer Society
2023
University of Amsterdam
1994-2021
Fondazione IRCCS Istituto Nazionale dei Tumori
2020
Abstract Human papillomavirus type 16 (HPV16) plays a role in the development of subgroup head and neck squamous cell carcinomas (HNSCC). However, uncertainty exists about true impact HPV this tumor as conflicting reports have been published with prevalence rates from 0 to 100%. We aimed find detection algorithm biologically thus clinically meaningful infection, applicable for high‐throughput screening frozen formalin‐fixed paraffin embedded (FFPE) specimens. By considering E6 oncogene...
Background: Transcriptionally active high-risk human papilloma viruses (HPVs), particularly HPV type 16 (HPV16), are found in a subset of head and neck squamous-cell carcinomas (HNSCCs). HPV16-associated carcinogenesis is mediated by expression the viral E6 E7 oncoproteins, which cause deregulation cell cycle inactivating p53 pRb, respectively. We tested hypothesis that HPV-associated HNSCCs display pattern genetic alterations different from those without DNA. Methods: Polymerase chain...
Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets involved in cancer progression and considered a promising biosource detection, as they alter their RNA content upon local systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the of 18 types. With 99% specificity asymptomatic controls, thromboSeq correctly detected presence two-thirds 1,096 samples stage I–IV half 352 I–III...
High-risk human papillomaviruses (HPVs) have been proposed to be associated with a subset of head and neck cancers (HNSCCs). However, clear biological evidence linking HPV-mediated oncogenesis the development HNSCC is hardly available. An important mechanism underlying carcinogenesis inactivation p53 by HPV E6 oncoprotein. In present study we investigated this relationship between HNSCC. total 84 tumors were analyzed for presence high-risk nucleic acids DNA polymerase chain reaction-enzyme...
Abstract Human papillomavirus (HPV) infection has been etiologically linked to oropharyngeal squamous cell carcinoma (OPSCC). The prevalence of HPV‐positive OPSCC varies between studies, ranging from 20 90%. This may be related the lack a standardized HPV detection assay as well time period in which is investigated, rising incidence rates are reported over last decades. Here, we validated our previously defined test algorithm for formalin‐fixed paraffin‐embedded (FFPE) tumor specimen...
Based on recent genetic studies, we propose a progression model for the development of oral squamous cell carcinoma. In initial phase, stem acquires alteration; subsequently patch is formed, clonal unit consisting with its daughter cells that all share DNA alteration. The next critical step conversion into an expanding field as result additional alterations. This mucosal replaces normal epithelium and in cavity such fields have been detected dimensions over 7 cm diameter. Sometimes these are...
Human papillomavirus (HPV) positive oropharyngeal cancer (oropharyngeal squamous cell carcinoma, OPSCC) is biologically and clinically different from HPV negative OPSCC. Here, we evaluate the use of a radiomic approach to identify status OPSCC.Four independent cohorts, totaling 778 OPSCC patients with determined by p16 were collected. We randomly assigned 80% all data for model training (N = 628) 20% validation 150). On pre-treatment CT images, 902 features calculated gross tumor volume....
Recent studies have reported that p16 protein overexpression qualifies as a surrogate marker identifying an oncogenic human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC). However, there is still percentage of OPSCCs are positive for immunohistochemistry (p16 IHC) but lack HPV DNA. The objective this study was to characterize group at the molecular level by performing sensitive DNA- and RNA-based PCR methods genetic profiling. All patients diagnosed with...