A5084656854- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Transplantation: Methods and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Organ and Tissue Transplantation Research
- Chronic Lymphocytic Leukemia Research
- Tracheal and airway disorders
- Monoclonal and Polyclonal Antibodies Research
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Migraine and Headache Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Structural Anomalies and Repair
- Neural dynamics and brain function
- Trigeminal Neuralgia and Treatments
- T-cell and B-cell Immunology
- Statistical Methods and Inference
- Analytical Methods in Pharmaceuticals
- Mitochondrial Function and Pathology
- Pleural and Pulmonary Diseases
- Vascular Anomalies and Treatments
National Institute of Mental Health
2024-2025
National Institutes of Health
2024-2025
University of Copenhagen
2016-2025
Stanford University
2021-2024
Rigshospitalet
1999-2024
Copenhagen University Hospital
1996-2022
The Alan Turing Institute
2021
Aalborg University Hospital
2010-2016
Svendborg Sygehus
2012
Aarhus University
2012
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles...
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in human brain and plays a key role several functions neuropsychiatric disorders such as anxiety, epilepsy, depression. For decades, vivo ex techniques have been used to highlight mechanisms of GABA system, however, no studies currently combined create high-resolution multimodal view system. Here, we present quantitative atlas benzodiazepine receptor sites (BZR) located on postsynaptic ionotropic GABAA receptors...
The Brain Imaging Data Structure (BIDS) is a standard for organizing and describing neuroimaging datasets, serving not only to facilitate the process of data sharing aggregation, but also simplify application development new methods software working with data. Here, we present an extension BIDS include positron emission tomography (PET) data, known as PET-BIDS, share several open-access datasets curated following PET-BIDS along tools conversion, validation analysis datasets.
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter and transporters play a key role in shaping brain function. Due to the lack of comprehensive receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as proxy for receptor densities. In present report, we comprehensively test spatial correlation protein total 27 receptors, binding-sites, across 9 different systems, using both PET autoradiography...
Objective: To describe the long-term prognosis after repair of Tetralogy Fallot with pulmonary stenosis beyond 20 years. Methods: One hundred and eighty five patients underwent corrective at Rigshospitalet in Copenhagen between January 1960 July 1977. Ninety seven had undergone a palliative operation prior to repair. All 125 who were discharged from hospital traced through population register alive 1997 contacted by mail and/or telephone questioned about use medicine, professional status,...
To evaluate the effect of wire removal on a consecutive series patients with persistent anterior chest wall pain after median sternotomy.Ninety-five receiving sternal during period January 1994-October 2001 were included in follow-up study. Preoperative data, data from primary operation, postoperative course, and collected patient histories. The attempted contacted by telephone, interviewed about outcome removal.Wire removals performed 2.7+/-3.3 (SD) years (40 days-20 years) procedure. Wire...
It is a growing concern that outcomes of neuroimaging studies often cannot be replicated. To counteract this, the magnetic resonance (MR) community has promoted acquisition standards and created data sharing platforms, based on consensus how to organize share MR data. Here, we take similar approach positron emission tomography (PET) facilitate comparison findings across studies, first recommend publication for tracer characteristics, image acquisition, preprocessing, outcome estimation PET...
Abstract As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity its attenuation of economic, physical, and legal barriers effectively enabled individuals from groups that have traditionally underrepresented to join participate. A number studies outlined how moving made it possible gather more community increased opportunities for with various constraints, e.g., caregiving responsibilities. Yet,...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macroscale neuroanatomy and how they shape emergent function remains poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from >1 200 healthy individuals to construct a whole-brain 3-D normative 19 transporters across 9 different neurotransmitter systems. We find that profiles align with structural...
Migraine has been hypothesized to be a syndrome of chronic low serotonin (5-HT) levels, but investigations brain 5-HT levels have given equivocal results. Here, we used positron emission tomography (PET) imaging the 5-HT4 receptor as proxy for levels. Given that is inversely related between attacks migraine patients would higher binding compared controls. Eighteen without aura (migraine free >48 h), and 16 age- sex-matched controls underwent PET scans after injection [11C]SB207145, specific...
The purpose of this study was to investigate and assess the correlation reproducibility multiparametric imaging in head neck cancer patients.
A low cardiac output state is an important cause of morbidity after pediatric cardiopulmonary bypass. The objectives our study were to define the early precipitants reduced and investigate effects on these milrinone levosimendan in a model bypass.Experimental study.: Research laboratory at university-affiliated, tertiary center.Eighteen piglets.Piglets, instrumented with systemic, pulmonary arterial, coronary sinus catheters, circumflex arterial flow probes, left ventricular...
SynopsisMotivation: Create an open-source alternative to FSL’s eddy without commercial limitations thatgeneralizes over problems beyond current distortions of diffusion MRI.Goals: Evaluate the tool’s performance vis-à-vis with corresponding tools.Approach: We implement a Gaussian Process regressor model and Bayesian optimizationlayer on existing registration framework, estimate alignment neuroimaging dataenabled by eddymotion framework.Results: Using publicly available data, we provide...
Abstract Sharing neuroimaging data upon a direct personal request can be challenging both for researchers who the and those agree to share their data. Unlike sharing through repositories under standardized protocols use/sharing agreements, each party often needs negotiate terms of use case by case. This negotiation unfolds against complex backdrop ethical regulatory requirements along with technical hurdles related transfer management. These challenges significantly delay process, if not...
Abstract Being able to aggregate results from many acceptable data analysis pipelines (multiverse analyses) is a desirable feature in almost all aspects of imaging neuroscience. This because multiple noise sources may contaminate the acquired data, and different will attenuate or remove those source effects differentially. Here, we used preprocessing that are known impact final conclusions Positron Emission Tomography (PET) neuroimaging studies significantly. We developed conceptual...
To study the frequency of histological obliterative bronchiolitis and clinical obliterans syndrome after en bloc double lung transplantation with bronchial artery revascularization bilateral without revascularization.Primary using internal mammary as conduit was performed in 62 patients. The frequencies have been established from transbronchial biopsies function measurements. Results analyzed relation to arteriographic success compared results Stanford University, obtained through personal...
Introduction: Postoperative pain-management with non-steroid anti-inflammatory drugs has been controversial, due to related side-effects. We investigated whether there was a significant difference between an oxycodone-based regimen versus slow-release ibuprofen based regimen, in short term post-cardiac surgery setting. Particular attention given the rate of myocardial infarction, sternal healing, gastro-intestinal complications, renal failure and all-cause mortality. Methods: This...
Background The pathophysiology of migraine may involve dysfunction serotonergic signaling. In particular, the 5-HT 1B receptor is considered a key player due to efficacy agonists for treatment attacks. Aim To examine cerebral binding in interictal patients without aura compared controls. Methods Eighteen patients, who had been free >48 hours, and 16 controls were scanned after injection specific radioligand [ 11 C]AZ10419369 quantification binding. Patients reported <48 hours PET...
Abstract Molecular imaging analyses using positron emission tomography (PET) data often rely on macro-anatomical regions of interest (ROI), which may not align with chemo-architectural boundaries and obscure functional distinctions. While methods such as independent component analysis (ICA) have been useful to address this limitation, the fully data-driven nature can make it challenging compare results across studies. Here, we introduce NeuroMark PET approach, utilizing spatially constrained...
SynopsisMotivation: Create an open-source alternative to FSL’s eddy without commercial limitations thatgeneralizes over problems beyond current distortions of diffusion MRI.Goals: Evaluate the tool’s performance vis-à-vis with corresponding tools.Approach: We implement a Gaussian Process regressor model and Bayesian optimizationlayer on existing registration framework, estimate alignment neuroimaging dataenabled by eddymotion framework.Results: Using publicly available data, we provide...