A5085556975- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Lanthanide and Transition Metal Complexes
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Radiopharmaceutical Chemistry and Applications
- Diet and metabolism studies
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
National Institutes for Quantum Science and Technology
2016-2025
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
The Open University of Japan
2021
Imagerie et Cerveau
2005-2020
Jikei University School of Medicine
1990-2020
Chiba University
1993-2018
National Center for Geriatrics and Gerontology
2017-2018
Mie University
2018
Kobe University
2018
The authors developed and applied two new linearized reference tissue models for parametric images of binding potential ( BP) relative delivery R 1 ) [ 11 C]DASB positron emission tomography imaging serotonin transporters in human brain. original multilinear model (MRTM O was modified (MRTM) used to estimate a clearance rate k′ 2 from the cerebellum (reference). Then, number parameters reduced three (MRTM2) by fixing . resulting BP estimates were compared with corresponding nonlinear models,...
We often evaluate the self and others from social comparisons. feel envy when target person has superior self-relevant characteristics. Schadenfreude occurs envied persons fall grace. To elucidate neurocognitive mechanisms of schadenfreude, we conducted two functional magnetic resonance imaging studies. In study one, participants read information concerning characterized by levels possession self-relevance comparison domains. When person's was self-relevant, stronger anterior cingulate...
<b>Objective:</b> To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and Lewy bodies (DLB). <b>Methods:</b> Participants included 18 patients PD, 21 PDD/DLB, 26 healthy controls. The group consisted of nine early each a duration less than 3 years, five whom were de novo patients, advanced greater or equal to years. PDD/DLB 10 PDD 11 DLB. All subjects underwent PET scans <i>N</i>-[<sup>11</sup>C]-methyl-4-piperidyl acetate measure...
Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed conformers (i.e. strains) unique to each illness. The development imaging agents has enabled visualization lesions in tauopathy patients, but the modes their binding different strains remain elusive. Here we compared positron emission tomography ligands, PBB3 and AV-1451, fluorescence, autoradiography homogenate assays with homologous heterologous blockades using brain samples. Fluorescence microscopy...
Deposition of α-synuclein fibrils is implicated in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), while vivo detection pathologies these illnesses has been challenging. Here, we have developed a small-molecule ligand, C05-05, for visualizing deposits the brains living subjects. In optical positron emission tomography (PET) imaging mouse marmoset models demonstrated that C05-05 captured dynamic propagation fibrillogenesis along neural pathways, followed by disruptions...
We provide the first evidence for capability of a high-resolution positron emission tomographic (PET) imaging system in quantitatively mapping amyloid accumulation living precursor protein transgenic (Tg) mice. After intravenous administration N -[ 11 C]methyl-2-(4′-methylaminophenyl)-6-hydroxybenzothiazole (or [ C]PIB “Pittsburgh Compound-B”) with high-specific radioactivity, Tg mice exhibited high-level retention radioactivity amyloid-rich regions. PET investigation over an extended range...
Abstract Elucidating the neural and genetic factors underlying psychiatric illness is hampered by current methods of clinical diagnosis. The identification investigation endophenotypes may be one solution, but represents a considerable challenge in human subjects. Here we report that mice heterozygous for null mutation alpha-isoform calcium/calmodulin-dependent protein kinase II (alpha-CaMKII+/-) have profoundly dysregulated behaviours impaired neuronal development dentate gyrus (DG)....
<h3>Background</h3> The clinical efficacy of dopamine D<sub>2</sub>receptor antagonism on the psychotic symptoms schizophrenia has been widely demonstrated. However, most in vivo imaging studies have not able to detect significant changes striatal D<sub>2</sub>receptors schizophrenia. On other hand, a number reported abnormalities cerebral cortex aim this study was examine extrastriatal patients with <h3>Methods</h3> Eleven drug-naive male were examined positron emission tomography using...
Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction. To understand relationship between pathology and behavioral impairments, we comprehensively assessed abnormalities in a mouse tauopathy model expressing human P301S mutant early stage disease detect its initial neurological manifestations. Behavioral abnormalities, shown open field test, elevated plus-maze hot plate Y-maze Barnes maze Morris...
Abstract The cocaine congener β‐CIT has been labeled with 11 C for positron emission tomographic (PET) studies of the dopamine transporter. In present autoradiographic study on human' brain sections and PET monkey human [ C]β‐CIT accumulated markedly in striatum. binding striatum was selective to thalamus an intermediate level displaced by compounds having affinity norepinephrine serotonin transporters. neocortical a low could be only citalopram, uptake inhibitor. A high dose intravenously...