Yoshiro Okubo

ORCID: 0000-0003-1767-0230
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About
Contact & Profiles
Research Areas
  • Balance, Gait, and Falls Prevention
  • Schizophrenia research and treatment
  • Cerebral Palsy and Movement Disorders
  • Functional Brain Connectivity Studies
  • Neurotransmitter Receptor Influence on Behavior
  • Neuroscience and Neuropharmacology Research
  • Epilepsy research and treatment
  • Treatment of Major Depression
  • Medical Imaging Techniques and Applications
  • Advanced MRI Techniques and Applications
  • EEG and Brain-Computer Interfaces
  • Electroconvulsive Therapy Studies
  • Neural and Behavioral Psychology Studies
  • Stroke Rehabilitation and Recovery
  • Musculoskeletal pain and rehabilitation
  • Psychosomatic Disorders and Their Treatments
  • Nutrition and Health in Aging
  • Physical Activity and Health
  • Advanced Neuroimaging Techniques and Applications
  • Receptor Mechanisms and Signaling
  • Neurological disorders and treatments
  • Frailty in Older Adults
  • Neuroscience and Music Perception
  • Dementia and Cognitive Impairment Research
  • Bipolar Disorder and Treatment

UNSW Sydney
2016-2025

Nippon Medical School
2016-2025

Neuroscience Research Australia
2016-2025

Gunma Chuo Hospital
2023

Nippon Medical School Hospital
2009-2022

Japan Society for the Promotion of Science
2011-2019

University of Tsukuba
2011-2018

Tokyo Medical University
2000-2018

Kyoto University
2017

Jikei University School of Medicine
2017

We often evaluate the self and others from social comparisons. feel envy when target person has superior self-relevant characteristics. Schadenfreude occurs envied persons fall grace. To elucidate neurocognitive mechanisms of schadenfreude, we conducted two functional magnetic resonance imaging studies. In study one, participants read information concerning characterized by levels possession self-relevance comparison domains. When person's was self-relevant, stronger anterior cingulate...

10.1126/science.1165604 article EN Science 2009-02-13

<h3>Background</h3> The clinical efficacy of dopamine D<sub>2</sub>receptor antagonism on the psychotic symptoms schizophrenia has been widely demonstrated. However, most in vivo imaging studies have not able to detect significant changes striatal D<sub>2</sub>receptors schizophrenia. On other hand, a number reported abnormalities cerebral cortex aim this study was examine extrastriatal patients with <h3>Methods</h3> Eleven drug-naive male were examined positron emission tomography using...

10.1001/archpsyc.59.1.25 article EN Archives of General Psychiatry 2002-01-01

Inflammatory/immunological process and glial contribution are suggested in the pathophysiology of schizophrenia. We investigated peripheral benzodiazepine receptors brains patients with chronic schizophrenia, which were reported to be located on mitochondria cells, using [11C]DAA1106 positron emission tomography. Fourteen 14 age- sex-matched normal controls participated this study. PET data analysed by two-tissue compartment model metabolite-corrected plasma input. Clinical symptoms assessed...

10.1017/s1461145710000313 article EN The International Journal of Neuropsychopharmacology 2010-03-30

Dopamine D 1 receptors in the prefrontal cortex (PFC) are important for functions, and it is suggested that stimulation of induces an inverted U-shaped response, such too little or much receptor impairs functions. Less known role 2 cognition, but previous studies showed hippocampus (HPC) might play some roles via HPC–PFC interactions. We measured both PFC HPC using positron emission tomography healthy subjects, with aim elucidating how regional differentially involved frontal lobe functions...

10.1523/jneurosci.3446-08.2008 article EN cc-by-nc-sa Journal of Neuroscience 2008-11-12

Abstract The human serotonin transporter (5‐HTT) gene has a polymorphism in the 5′‐flanking promoter region that is called gene‐linked polymorphic (5‐HTTLPR). In lymphoblast cell lines, activity of 5‐HTT dependent on 5‐HTTLPR allelic variants. transcriptional l allele was more than twice as high s allele. considered to be associated with mood disorders and anxiety‐related personality traits. To evaluate functional differences brain vivo, we examined variations measured binding living using...

10.1002/syn.10204 article EN Synapse 2003-03-25

Abstract It is known that autonomic nervous activities change in correspondence with sleep stages. However, the characteristics of continuous fluctuations nocturnal nerve tone have not been clarified detail. The study aimed to determine possible correlation between electroencephalogram (EEG) and activities, clarify detail activities. Overnight EEGs electrocardiograms seven healthy males were obtained. These analyzed by fast Fourier transformation algorithm extract delta, sigma beta power....

10.1046/j.1440-1819.2003.01080.x article EN Psychiatry and Clinical Neurosciences 2003-01-08

We aimed to investigate the neural correlates associated with judgments of a positive self-conscious emotion, pride, and elucidate difference between pride basic joy, at basis level using functional magnetic resonance imaging. Study might contribute better understanding pride-related behaviors observed in neuropsychiatric disorders. Sixteen healthy volunteers were studied. The participants read sentences expressing joy or contents during scans. Pride conditions activated right posterior...

10.1093/cercor/bhm120 article EN Cerebral Cortex 2007-07-17

Background— It is unclear whether mild hypertensive retinopathy a risk factor for mortality. This study examined could be cardiovascular mortality in subjects with and without hypertension. Methods Results— In this cohort study, 87 890 individuals (29 917 men 57 973 women) 40 to 79 years of age 1993 were followed up until 2008. Retinal photography was classified as normal, grade 1, or 2 based on the Keith-Wagener-Barker system. Risk ratios all-cause cause-specific each classification...

10.1161/circulationaha.111.049965 article EN Circulation 2011-11-08
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