A5042642751- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Advanced Neuroimaging Techniques and Applications
- Suicide and Self-Harm Studies
- Psychosomatic Disorders and Their Treatments
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Epilepsy research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Electroconvulsive Therapy Studies
- Neurological disorders and treatments
- Mental Health Treatment and Access
- Heart Rate Variability and Autonomic Control
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Fetal and Pediatric Neurological Disorders
- Mental Health and Psychiatry
- Poisoning and overdose treatments
- Advanced MRI Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Homicide, Infanticide, and Child Abuse
Yokohama City University
2012-2021
Juntendo University Urayasu Hospital
2019
Pfizer (United States)
2016
Numazu City Hospital
2014
Signature Healthcare Brockton Hospital
1997-2004
Brigham and Women's Hospital
1998-2004
Harvard University
1997-2004
McLean Hospital
1998-2004
VA Boston Healthcare System
2001-2004
Kyorin University
2000-2004
<h3>Background</h3> Basic science studies at the neuronal systems level have indicated that gamma-range (30-50 Hz) neural synchronization may be a key mechanism of information processing in networks, reflecting integration various features an object. Furthermore, is thought to depend on glutamatergically mediated interplay between excitatory projection neurons and inhibitory utilizing γ-aminobutyric acid (GABA), which postmortem suggest abnormal schizophrenia. We therefore tested whether...
OBJECTIVE: Smaller temporal lobe cortical gray matter volumes, including the left superior gyrus, have been reported in magnetic resonance imaging (MRI) studies of patients with chronic schizophrenia and, more recently, first-episode schizophrenia. However, it remains unknown whether there are progressive decreases volumes and similarly volume present affective psychosis. METHOD: High-spatial-resolution MRI scans at initial hospitalization 1.5 years later were obtained from 13 schizophrenia,...
Background:The Heschl gyrus and planum temporale have crucial roles in auditory perception language processing.Our previous investigation using magnetic resonance imaging (MRI) indicated smaller gray matter volumes bilaterally the left patients with firstepisode schizophrenia but not affective psychosis.We sought to determine whether there are progressive decreases anatomically defined MRI of also psychosis.Methods: At a private psychiatric hospital, we conducted prospective high spatial...
Objective:Magnetic resonance imaging (MRI) studies of schizophrenic patients have revealed structural brain abnormalities, with low volumes gray matter in the left posterior superior temporal gyrus and medial lobe structures. However, specificity to schizophrenia roles chronic morbidity neuroleptic treatment these abnormalities remain unclear. Method:Magnetic (1.5-T) scans were obtained from 33 first-episode psychosis 18 age-matched normal comparison subjects, all right-handed. Sixteen...
Gray matter volume and glucose utilization have been reported to be reduced in the left subgenual cingulate of subjects with familial bipolar or unipolar depression. It is unclear whether these findings are secondary recurrent illness part a familial/genetic syndrome. The authors' goal was clarify findings.Volumetric analyses were performed by using magnetic resonance imaging 41 patients experiencing their first episode affective disorder schizophrenia 20 normal comparison subjects.The who...
Magnetic resonance imaging studies in schizophrenia have revealed abnormalities temporal lobe structures, including the superior gyrus. More specifically, been reported posterior gyrus, which includes Heschl gyrus and planum temporale, latter being an important substrate for language. However, specificity of temporale structural to vs affective psychosis, possible confounding roles chronic morbidity neuroleptic treatment, remain unclear.Magnetic images were acquired using a 1.5-T magnet from...
Anxiety a core feature of panic disorder, is linked to function the amygdala. Volume alterations in brain patients with disorder have previously been reported, but there has no report amygdala volume association anxiety.Volumes hippocampus and were manually measured using magnetic resonance imaging obtained from 27 30 healthy comparison subjects. In addition was focused on, applying small correction optimized voxel-based morphometry (VBM). State-Trait Inventory NEO Personality Revised also...
Major depressive disorder (MDD) is an important public health problem, and it often comorbid with many chronic diseases. The purpose of this study was to identify the clinical features non-alcoholic fatty liver disease (NAFLD) patients MDD investigate influence on effect treatment in NAFLD.A total 258 biopsy-proven NAFLD were included. diagnosed according criteria Diagnostic Statistical Manual Mental Disorders, 4th edition, text revision. followed up for 48 weeks under standard care NAFLD,...
The planum temporale, located on the posterior and superior surface of temporal lobe, is a brain region thought to be biological substrate language possibly implicated in pathophysiology schizophrenia. To investigate further role temporale abnormalities schizophrenia, we measured gray matter volume underlying from high spatial resolution magnetic resonance imaging techniques.Sixteen male patients with chronic schizophrenia 16 control subjects were matched for age, sex, handedness, parental...
<h3>Background</h3> In chronic schizophrenia, the P300 is broadly reduced and shows a localized left temporal deficit specifically associated with gray matter volume of posterior superior gyrus (STG). first-episode patients, similar present in but not affective psychosis. The study investigated whether P300–left STG association selectively schizophrenia. <h3>Method</h3> was recorded as subjects schizophrenia (n =15) or psychosis = 18) control silently counted infrequent target tones amid...
OBJECTIVE: A cavum between the septi pellucidi may reflect neurodevelopmental anomalies in midline structures of brain. The authors examined subjects with schizophrenia, affective disorder, and schizotypal personality disorder normal subjects. METHOD: Thirty schizophrenic patients (15 chronic, 15 first-episode), 16 (first-episode), 21 46 were evaluated magnetic resonance imaging. Cavum was assessed by counting number 1.5-mm slices containing pellucidi. RESULTS: presence or absence did not...
Recent evidence suggests that the cerebellum may play a role in higher cognitive functions and, therefore, an important schizophrenia.The authors used magnetic resonance imaging to measure and vermis volume 15 patients with schizophrenia normal comparison subjects.They found 1) was greater than subjects, 2) white matter significantly correlated severity of positive symptoms thought disorder impairment verbal logical memory, 3) showed trend for more cerebellar hemispheric asymmetry (left...
Functional measures have consistently shown prefrontal abnormalities in schizophrenia. However, structural magnetic resonance imaging (MRI) findings of volume reduction been less consistent. In this study, we evaluated gray matter first episode (first hospitalized) patients diagnosed with schizophrenia, compared affective psychosis and normal comparison subjects, to determine the presence specificity Prefrontal white volumes were measured from schizophrenia (n = 17), genderand parental...
OBJECTIVE: "Cognitive" circuits anatomically link the frontal lobe to subcortical structures; therefore, pathology in any of core components these circuits, such as caudate nucleus, may result neurobehavioral syndromes similar those lobe. Neuroleptic medication, however, affects size nucleus. For this reason, individuals diagnosed with schizotypal personality disorder offer an ideal group for measurement nucleus because they be genetically related schizophrenia but do not require neuroleptic...
Although treatment with antipsychotics, particularly olanzapine and clozapine, has been implicated in weight gain higher incidence of diabetes, the mechanism these adverse reactions remains unclear. The purposes this study were to explore early effects on serum levels ghrelin, adiponectin leptin, three recently identified hormones that play crucial roles regulation energy balance glucose metabolism. Thirteen patients schizophrenia who had not received any medication 4 weeks prior included....
Objective: Magnetic resonance imaging (MRI) studies of schizophrenia reveal temporal lobe structural brain abnormalities in the superior gyrus and amygdala-hippocampal complex. However, middle inferior gyri have received little investigation, especially first-episode schizophrenia. Method: High-spatial-resolution MRI was used to measure gray matter volume inferior, middle, 20 patients with schizophrenia, affective psychosis, 23 healthy comparison subjects. Results: Gray smaller bilaterally...
Aim: Recent neuroimaging studies have suggested that the anterior cingulate cortex (ACC) has an important role in pathology of panic disorder. Despite numerous functional elucidated strong relationship between abnormalities ACC and disorder its symptoms response to emotional tasks associated with disorder, there been no study showing volumetric changes or subregions. Methods: To clarify structural subregions, combination region interest (ROI) optimized voxel‐based morphometry (VBM) methods...