A5075794406- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Aortic aneurysm repair treatments
- Asthma and respiratory diseases
- RNA and protein synthesis mechanisms
- Food Allergy and Anaphylaxis Research
- Aortic Disease and Treatment Approaches
- Bacterial Genetics and Biotechnology
- Infectious Aortic and Vascular Conditions
- Immune Response and Inflammation
- Functional Brain Connectivity Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Transgenic Plants and Applications
- RNA modifications and cancer
- Infective Endocarditis Diagnosis and Management
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Advancements in Transdermal Drug Delivery
- Genomics and Chromatin Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Mechanical Circulatory Support Devices
University of Rochester Medical Center
2015-2024
Kurume University
2024
Suita Tokushukai Hospital
2013-2022
University of Rochester
2009-2021
Saga University
2016
Sahlgrenska University Hospital
2012-2016
University of Gothenburg
2012-2016
Osaka University Hospital
2016
Ehime University
2015
University of Occupational and Environmental Health Japan
2003-2012
The skin, the largest organ of body, is an essential barrier that under homeostatic conditions efficiently protects and/or minimizes damage from both environmental (e.g. microorganisms, physical trauma, ultraviolet radiation) and endogenous (e.g., cancers, inflammation) factors. This formidable function resides mainly in epidermis, a dynamic, highly-stratified epithelium. epidermis has 2 major structures: stratum corneum, outmost layer tight junctions, intercellular junctions seal adjacent...
The ompF and ompC genes of Escherichia coli are reciprocally regulated by a single transcription factor, phosphorylated OmpR (OmpR-P), depending upon medium osmolarity. This regulation involves activation its repression with concomitant ompC. occurs through OmpR-P binding to four (F1, F2, F3, F4) three (C1, C2, C3) sites located upstream the promoters, respectively, novel mechanism. Here we show that there is distinct hierarchy within F1, F3 as well C1, C3 sites. Each these contains two...
Anxiety a core feature of panic disorder, is linked to function the amygdala. Volume alterations in brain patients with disorder have previously been reported, but there has no report amygdala volume association anxiety.Volumes hippocampus and were manually measured using magnetic resonance imaging obtained from 27 30 healthy comparison subjects. In addition was focused on, applying small correction optimized voxel-based morphometry (VBM). State-Trait Inventory NEO Personality Revised also...
Diffusion tensor imaging provides a new approach for quantifying anisotropic diffusion of white matter in vivo. We used this technique to investigate subtle disruption regional schizophrenia. Twelve patients with schizophrenia were compared 11 healthy controls. Psychotic symptoms assessed using the Positive and Negative Syndrome Scale. A significant fractional anisotropy (FA) reduction was found all regions bilaterally schizophrenic patients. Higher FA left frontal correlated significantly...
Ribonucleases, antibiotics, bacterial toxins, and viruses inhibit protein synthesis, which results in apoptosis mammalian cells. How the BCL-2 family of proteins regulates response to shutoff synthesis is not known. Here we demonstrate that an Escherichia coli toxin, MazF, inhibited by cleavage cellular mRNA induced MazF-induced required proapoptotic BAK its upstream regulator, BH3-only NBK/BIK, but BIM, PUMA, or NOXA. Interestingly, MazF induction, NBK/BIK activated displacing it from...
The Streptococcus pyogenes cell-surface protein Scl2 contains a globular N-terminal domain and collagen-like domain, (Gly-Xaa-X′aa)79, which forms triple helix with thermal stability close to that seen for mammalian collagens. Hyp is major contributor triple-helix in animal collagens, but not present bacteria, lack prolyl hydroxylase. To explore the basis of bacterial collagen absence Hyp, biophysical studies were carried out on recombinant protein, isolated from Scl2, set peptides modeling...
Most histidine kinases are bifunctional enzymes having both kinase and phosphatase activities. The cytoplasmic domain of EnvZ, a transmembrane functioning as an osmosensor in Escherichia coli , consists two distinct functional subdomains: A [EnvZc(223–289)] B [EnvZc(290–450)]. NMR studies demonstrated that four-helix bundle serving dimerization phosphotransfer domain, functions the ATP-binding catalytic domain. Here we demonstrate by itself has activity vitro vivo . This is Mg 2+ dependent...
Cloning a cDNA for human IgGFc binding protein (FcγBP) from colonic epithelial cells reveals an mRNA and coding region of 17 16.2 kilobases, respectively. The predicted amino acid sequence contains 12 occurrences 400-amino cysteine-rich unit resembling that found in mucin. A motif (CGLCGN) FcγBP is conserved MUC2 prepro-von Willebrand factor. N-terminal 450-amino sequences are necessary sufficient to confer IgG Fc activity. expressed only placenta cells. These results suggest may play...
<b>Background and aims:</b> Mucus released from goblet cells is important in intestinal mucosal defence, mucin glycoproteins are thought to be major components of mucus. Recently, we identified cloned another component human colonic mucus, IgG Fc binding protein (FcγBP). FcγBP immunologically distinct known Fcγ receptors its structure contains repeated cysteine rich unit sequences resembling those present mucins. In this work, assessed the tissue distribution FcγBP, activity various body...
This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients. Diffusion tensor imaging performed 8 patients and 12 healthy age-matched controls. The were scanned before after a course ECT. Fractional anisotropy (FA) determined temporal regions corpus callosum. A significant FA reduction found widespread brain with depression ECT treatment compared increase seen following treatment. bilateral ameliorated integrity...
The posterior region of the orbitofrontal cortex (OFC), which forms its sulcogyral pattern during neurodevelopment, receives multisensory inputs. purpose present study was to assess relationship between OFC and volume difference in patients with panic disorder.The anatomical orbital sulcus (POS) classified into three subtypes (absent POS, single double POS) using 3-D high-spatial resolution magnetic resonance images obtained from 28 disorder age- gender-matched healthy controls. Optimized...