A5000312765- Cardiac Imaging and Diagnostics
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Neural dynamics and brain function
- Advanced X-ray and CT Imaging
- Functional Brain Connectivity Studies
- Optical Imaging and Spectroscopy Techniques
- Neurological Disease Mechanisms and Treatments
- Cardiomyopathy and Myosin Studies
- CRISPR and Genetic Engineering
- Cutaneous Melanoma Detection and Management
- Medical Imaging Techniques and Applications
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Mesenchymal stem cell research
- Cutaneous lymphoproliferative disorders research
- Cardiac Structural Anomalies and Repair
- bioluminescence and chemiluminescence research
- Parkinson's Disease Mechanisms and Treatments
- Infective Endocarditis Diagnosis and Management
- Lymphatic System and Diseases
Tohoku University
2023-2025
National Institutes for Quantum Science and Technology
2018-2024
Chiba University
2019-2023
Kagoshima University
2018-2022
Okayama University
2019
Fukushima Medical University
2018
Center for Global Health
2018
National Center for Global Health and Medicine
2018
Ishikawa Prefectural University
2016
The University of Tokyo
2000
Deposition of α-synuclein fibrils is implicated in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), while vivo detection pathologies these illnesses has been challenging. Here, we have developed a small-molecule ligand, C05-05, for visualizing deposits the brains living subjects. In optical positron emission tomography (PET) imaging mouse marmoset models demonstrated that C05-05 captured dynamic propagation fibrillogenesis along neural pathways, followed by disruptions...
Intake of specific seven essential amino acids affects the pathology brain.
In Alzheimer's disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) thought to be one the key biological mechanisms hyperexcitability. However, it still unknown how INs are functionally affected in tau pathology, which a major pathology AD. To clarify this, we evaluated neuronal activity cortical 6-month-old rTg4510 mice, model tauopathy. Calcium imaging mDlx enhancer-driven labeling...
To assess if magnetic resonance spectroscopy (MRS)-measured Glutamate (Glu) and GABA reflect excitatory inhibitory neural activities, respectively, we conducted MRS measurements along with two-photon mesoscopic imaging of calcium signals in neurons living, unanesthetized mice. For monitoring stimulus-driven activations a brain region, activities were measured during two consecutive sessions 15-min prolonged sensory stimulations. In the first session, putative neuronal increased, while...
The combination of BRAF and MEK kinase inhibitors is a well-established treatment for V600-mutated advanced melanoma. However, the efficacy these therapies against less common mutations, such as L597, remains unclear. We report two cases melanoma harboring L597 mutation. In first case, 77-year-old man with metastatic achieved complete remission following therapy nivolumab ipilimumab. second 50-year-old woman exhibited resistance to multiple systemic therapies, including nivolumab,...
Mycosis fungoides (MF) is an indolent form of cutaneous T‐cell lymphoma. Its early lesions are important to be distinguished from atopic dermatitis (AD) because their similar immune microenvironment. We have previously demonstrated that several chemokines involved in the pathogenesis advanced MF. Therefore, we sought comprehensively analyze changes environment during phase MF by focusing on serum cytokines and identify potential biomarkers for detection transition Sera 11 cases...
Chronic cerebral hypoperfusion (CCH) has been indicated to impair cognitive and diverse brain functions. However, the neural mechanisms linking these cerebrovascular phenotypic alterations remain unclear. Here, we investigated effect of CCH on neuronal activity in male mice with unilateral common carotid artery occlusion using optical imaging MRI. Our examinations revealed enhanced concurrence increased glutamate tissue acidosis up seven days after occlusion. At 21–28 occlusion, decreased...
Although many experts have attempted communication about radiation risk, fears exposure stemming from the Fukushima Daiichi Nuclear Power Plant accident remain deeply rooted. The characteristics of anxiety vary with social background, which makes it difficult to alleviate one approach. Our ultimate goal is therefore create risk-communication materials tailored various groups differing backgrounds. Towards that end, purpose present study was clarify potential factors associated...
Extracellular volume fraction (ECV) on magnetic resonance imaging can predict prognosis after aortic valve replacement in patients with stenosis (AS). However, the usefulness of ECV computed tomography (CT) for who have undergone transcatheter (TAVR) is unclear, so we investigated whether analysis CT associated clinical outcomes TAVR candidates.
SUMMRAY A panel of radiochemicals has enabled in-vivo positron emission tomography (PET) tau pathologies in Alzheimer’s disease (AD), while sensitive detection frontotemporal lobar degeneration (FTLD) inclusions been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse deposits. In-vitro assays demonstrated the reactivity this compound with AD and FTLD. We could also utilize PM-PBB3 optical/PET a living murine tauopathy model. subsequent clinical PET study...
Resource12 October 2021Open Access Source DataTransparent process A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains Masafumi Shimojo Corresponding Author [email protected] orcid.org/0000-0003-4491-7294 Department Functional Brain Imaging, National Institutes Quantum and Radiological Science Technology, Chiba, Japan Search more papers by this author Maiko Ono Hiroyuki Takuwa Koki Mimura Yuji Nagai Masayuki Fujinaga Radiopharmaceuticals Development,...
Objective Forward-projected Model-based Iterative Reconstruction SoluTion (FIRST) is a novel reconstruction method. We investigated the improvement in diagnostic performance for detection of abnormal late enhancement (LE) left ventricular myocardium (LVM) using new-generation 320-slice computed tomography (CT) device with FIRST. Methods This retrospective study that included 100 adult patients who underwent cardiac CT including phase scan and magnetic resonance imaging (MRI) within 3 months....
SUMMARY Deposition of α-synuclein fibrils is implicated in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), while vivo detection pathologies these illnesses has been challenging. Here, we have developed a small-molecule ligand, C05-05, for visualizing deposits the brains living subjects. In optical positron emission tomography (PET) imaging mouse marmoset models demonstrated that C05-05 captured dynamic propagation fibrillogenesis along neural pathways followed by disruptions...
Chronic cerebral hypoperfusion model mice were created by unilateral common carotid artery occlusion (UCCAO) surgery, which does not cause infarction, but long-term reduction in blood flow (CBF) to the occluded side. Cognitive dysfunction this mouse has been demonstrated behavioral experiments, neuron density change was found a previous positron emission tomography (PET) study. As next step, study we investigated injury of neuronal fibers chronic using diffusion tensor imaging (DTI).In...
The clinical analysis of cases bacteremia is valuable. However, limited data on are available in Vietnam. We conducted a single-center retrospective surveillance study at the Bach Mai Hospital, Hanoi, Vietnam between 2009 and 2012. In total, 45,366 blood cultures were analyzed. number per 1,000 patient-days was 9.59 sets. percentage solitary culture sets 49.6%, rate positive 13.9%. major pathogens isolated adults coagulase-negative Staphylococcus species (16.7%), followed by Escherichia coli...
The combination of BRAF kinase inhibitors (BRAFis) and MEK (MEKis) is one the most promising chemotherapy regimens in treatment BRAF-mutant melanoma. Although BRAFi plus MEKi combined therapy widely used for
Green fluorescence imaging (e.g., flavoprotein autofluorescence imaging, FAI) can be used to measure neuronal activity and oxygen metabolism in living brains without expressing proteins. It is useful for understanding the mechanism of various brain functions their abnormalities age-related diseases. However, hemoglobin cerebral blood vessels absorbs green fluorescence, hampering accurate assessments function animal models with vessel dysfunctions subsequent flow (CBF) alterations. In present...