A5082048145- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
- Microbial Community Ecology and Physiology
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Redox biology and oxidative stress
- T-cell and Retrovirus Studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Marine and coastal ecosystems
- Colorectal Cancer Surgical Treatments
- Microbial Fuel Cells and Bioremediation
- Pancreatic and Hepatic Oncology Research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Metastasis and carcinoma case studies
- Light effects on plants
- Biochemical and Molecular Research
- Metal-Catalyzed Oxygenation Mechanisms
- Adenosine and Purinergic Signaling
- Multiple and Secondary Primary Cancers
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Gastrointestinal disorders and treatments
Nagoya City University
2007-2024
Mizuho (Japan)
2002-2024
Nagoya Medical Center
2014-2022
Ajinomoto (Japan)
1990-2021
Mie University
2018
Ajinomoto (United States)
1990-2014
Kyoto University
1989-2007
Toyota Memorial Hospital
2004-2005
Massachusetts Institute of Technology
1999
University of Miami
1983-1996
Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments, including regulation of various intracellular molecules via thiol redox control. We produced TRX overexpressing mice confirmed that there were no anatomical physiological differences between wild-type (WT) transgenic (Tg) mice. In the present study we subjected to focal brain ischemia shed light on role ischemic injury. At 24 hr after middle cerebral artery occlusion, infarct areas volume...
Survivin, a new member of the inhibitor-of-apoptosis (IAP) family, has been reported to be expressed in many cancers but not differentiated normal tissue. Its expression esophageal cancer, however, reported. We investigated 51 and their adjacent epithelial tissues for mRNA survivin by RT-PCR. The cancer tissue was significantly higher than that (0.211 +/- 0.226 vs. 0.057 0.135, p < 0.0001). pN4 tumors had pN0-3 (p = 0.0093). Fourteen patients with advanced received chemotherapy prior...
Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of protein in variety stresses. Bone marrow cells from TRX-Tg more resistant ultraviolet C-induced cytocide compared with those wild type (WT) C57BL/6 mice. exhibited extended median and maximum life spans WT Telomerase activity spleen tissues was higher than that These results suggest overexpression TRX resistance against oxidative stress possible extension span...
Interleukin 1 (IL-1) has been obtained from the Epstein-Barr virus-infected B-lymphoblastoid cell line 3B6 and shown to be involved in autocrine growth of B cells. Independently, adult T-cell leukemia-derived factor (ADF) was purified human T-lymphotropic virus I-infected leukemic (ATL-2) reported as an interleukin 2 (IL-2) receptor-inducing factor. We have previously same molecular mass, pI, NH2-terminal amino acid sequence for both 3B6-derived IL-1 ADF. cDNA cloning ADF demonstrated high...
MicroRNAs (miRNA) are small noncoding RNAs thought to be involved in physiologic and developmental processes by negatively regulating the expression of target genes. Little is known about role miRNAs normal cancer cells. It possible that deregulation miRNA may contribute oncogenesis some cancers. We studied level processing enzyme (DICER1, DGCR8, RNASEN) esophageal squamous cell carcinoma (ESCC).The levels DICER1, RNASEN mRNA 73 ESCC tissues were compared with corresponding epithelium Taqman...
Transcription from the human immunodeficiency virus type 1 (HIV-1) provirus is activated by a cellular factor, NFκB, recognizing tandemly repeated 10-base-pair sequences, termed κB sequence, present in enhancer region within viral long terminal repeat (LTR). Using electrophoretic mobility shift assay (EMSA), which demonstrates specific DNA-protein interaction vitro, we could demonstrate that reducto-oxidatlve modulation of NFκB dramatically changes its DNA binding activity and physiological...
Thiol compounds, such as L-cysteine and glutathione (GSH), play crucial roles in the regulation of lymphocyte proliferation. In this study, we analyzed effect L-cystine GSH depletion on survival investigated regulatory adult T cell leukemia (ATL)-derived factor (ADF)/human thioredoxin (hTRX) relation to these low m.w. thiols. MT-1, MT-2, Jurkat cells underwent apoptosis when cultured L-cystine- GSH-free medium within 18 24 h. Dichlorofluorescin oxidation assay indicated that MT-1 MT-2 was...
Journal Article Extremely Low D/H Ratios of Photoproduced Hydrogen by Cyanobacteria Get access Yao-Hua Luo, Luo 1Department Biology, University MiamiCoral Gables, Florida 33124, U.S.A. Search for other works this author on: Oxford Academic Google Scholar Leonel Steinberg, Steinberg Shoichiro Suda, Suda 2Division Marine Biology and Fisheries, School Atmospheric Science, MiamiMiami, 33149, Shuzo Kumazawa, Kumazawa Akira Mitsui Plant Cell Physiology, Volume 32, Issue 6, September 1991, Pages...
Abstract Background The diagnosis of lymph node metastasis in esophageal cancer by the presence and number metastatic nodes is an extremely important prognostic factor. In addition, indication non-surgical therapy gaining more attention. Vascular endothelial growth factor C (VEGF-C) potentially lymphangiogenic selectively induces hyperplasia lymphatic vasculature. this study, we investigated expression VEGF-C whether it correlated with various clinico-pathologic findings. Methods KYSE series...
1. From leaves of barley and spinach, cellular components were isolated brought together under various conditions to investigate the fate ascorbic acid as affected by in light dark. 2. A new colorimetric method for assaying some other reducing substances was devised, measuring color molybdenum-blue developed presence excess amounts phosphomolybdate inorganic acid. 3. The photooxidation green yellow filtrates, prepared from etiolated barley, studied ordinary well method. In oxygen, oxidation...
The cancer‑stromal interaction has been demonstrated to promote tumor progression, and cancer-associated fibroblasts (CAFs), which are the main components of stromal cells, have attracted attention as novel treatment targets. Chitinase 3-like 1 (CHI3L1) is a chitinase-like protein, affects cell proliferation angiogenesis. However, mechanisms through cells secrete CHI3L1 mediates progression in cancer microenvironment still unclear. Accordingly, present study assessed secretion colorectal...
A sensitive assay using biotinylated ubiquitin revealed extensive ubiquitination of the large subunit RNA polymerase II during incubations transcription reactions in vitro. Phosphorylation repetitive carboxyl-terminal domain was a signal for ubiquitination. Specific inhibitors cyclin-dependent kinase (cdk)-type kinases suppress reaction. These are components factors and have been shown to phosphorylate domain. In both regulation DNA repair, phosphorylation by might degradation polymerase.
NDRG1 (N-myc downstream regulated gene-1) was reported to be necessary for p53-mediated apoptosis and by PTEN (phosphatase tensin homolog). In several cancers, it suggested a tumor suppressor gene. Its significance in esophageal squamous cell carcinoma (ESCC) has not been studied. The objective of this study clarify the relation between clinicopathological biologic factors determine prognostic expression NDRG1. Expression mRNA quantified real-time reverse transcription polymerase chain...
The effects of several key environmental factors on the development and control hydrogen production in marine blue-green alga (cyanobacterium) Oscillatoria sp. strain Miami BG7 were studied relation to potential application this a bio-solar energy technology. cellular biomass capable evolving gas was strongly affected by light intensity, temperature, input ammonia as nutrient. Depletion combined nitrogen from growth media prerequisite for initiation production. Maximum hydrogen-producing...
1. 5'-Nucleotidase [EC 3.1.3.5] was partially purified from rat liver acetone powder and it found to be kinetically distinct which had been reported in liver. 2. 5'-IMP 5'-GMP are the most active substrates among 5'-mononucleotides tested. 3. This enzyme has optimum pH at 6.5 requires bivalent metal ions. In absence of ions, is almost inactive. 4. Inosine, guanosine, PCMB NaF inhibit this enzyme. 5. shows highest activity with also obtained frog pig powder.
Intake of specific seven essential amino acids affects the pathology brain.