A5076153869- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Hernia repair and management
- Colorectal and Anal Carcinomas
- Minimally Invasive Surgical Techniques
- Anorectal Disease Treatments and Outcomes
- Angiogenesis and VEGF in Cancer
- Intestinal and Peritoneal Adhesions
- Colorectal Cancer Treatments and Studies
- Intestinal Malrotation and Obstruction Disorders
- Peptidase Inhibition and Analysis
- Diverticular Disease and Complications
- Cancer, Hypoxia, and Metabolism
- Glaucoma and retinal disorders
- Metastasis and carcinoma case studies
- Retinal Development and Disorders
- PARP inhibition in cancer therapy
- IgG4-Related and Inflammatory Diseases
- Stoma care and complications
- Esophageal and GI Pathology
- Intraperitoneal and Appendiceal Malignancies
Kariya Toyota General Hospital
2006-2025
Nagoya City University
2007-2023
Osaka University of Pharmaceutical Sciences
2021-2023
Mizuho (Japan)
2007-2022
Nagoya Medical Center
2022
Osaka Medical and Pharmaceutical University
2021
Weatherford College
2021
Apigenin is a natural flavonoid that exhibits anti-proliferative activity and induces apoptosis in various types of cancer, including colon cancer. The aim the present study was to determine mechanism underlying apoptosis-inducing effect apigenin reduced proliferation cancer cell lines, stimulated cleavage PARP induced dose-dependent manner. treatment also suppressed expression anti-apoptotic proteins Bcl-xL Mcl-1. Small interfering RNA used knockdown Mcl-1 alone concert, cells were...
The cancer‑stromal interaction has been demonstrated to promote tumor progression, and cancer-associated fibroblasts (CAFs), which are the main components of stromal cells, have attracted attention as novel treatment targets. Chitinase 3-like 1 (CHI3L1) is a chitinase-like protein, affects cell proliferation angiogenesis. However, mechanisms through cells secrete CHI3L1 mediates progression in cancer microenvironment still unclear. Accordingly, present study assessed secretion colorectal...
ABSTRACT Introduction Appendiceal intussusception is extremely rare, occurring in 0.01% of cases appendicitis. Endometriosis‐related the most common adults. Most reported require extensive surgery, such as ileocecal resection or right hemicolectomy. This case presents a minimally invasive surgical approach, involving partial cecal for an unreturned case. Materials and Surgical Technique A 47‐year‐old female presented with upper abdominal pain lasting 2 weeks. Examination revealed tenderness...
The repair of DNA damage caused by chemotherapy in cancer cells occurs mainly at two cell cycle checkpoints (G1 and G2) is a factor contributing to chemoresistance. Most colorectal cancers harbor mutations p53, the main pathway involved G1 checkpoint, thus, are particularly dependent on G2 checkpoint for repair. present study examined effect AZD6738, specific inhibitor ataxia telangiectasia mutated rad3‑related (ATR) combined with 5‑fluorouracil (5‑FU), central chemotherapeutic agent, cells....
Inflammatory pseudotumor (IPT) of the liver is a rare benign lesion. A case IPT found in association with malignant gastrointestinal stromal tumor (GIST) reported. 74-year-old man was admitted to our hospital for tumor. He previously underwent rectal amputation GIST. Computed tomography (CT) revealed low-density area and dynamic contrast-enhanced MRI (EOB-MRI) showed that completely washed out delayed phase. 18Fluorine-fluorodeoxyglucose positron emission (FDG-PET) strong uptake liver....
Abstract CBP-93872 was previously identified as a G2 checkpoint inhibitor using cell-based high-throughput screening system. However, its molecular actions well cellular targets are largely unknown. Here, we uncovered the mechanisms underlying abrogation of by CBP-93872. specifically abrogates DNA double-stranded break (DSB)–induced through inhibiting maintenance but not initiation arrest because specific inhibition DSB-dependent ATR activation. Hence, ATR-dependent phosphorylation Nbs1 and...
Ataxia telangiectasia and Rad3‑related (ATR) is a kinase that repairs DNA damage. Although inhibitors selectively target ATR have been developed, their effectiveness in colorectal cancer has not widely reported. The present study hypothesized anticancer agents effectively act the S phase before G2/M checkpoint may be ideal for concomitant use with inhibitors, which at checkpoint. Therefore, examined combined effects of AZD6738, an inhibitor, trifluridine (FTD), acts high uptake rate. In...
Robot-assisted laparoscopic surgery has been performed in various fields, especially the pelvic cavity. However, little is known about utility of robot-assisted rectal cancer associated with radical prostatectomy (RARP). We herein report clinical impact RARP.We experienced five cases RARP. One involved abdominoperineal resection en bloc for T4b cancer, and one intersphincteric combined RARP synchronous prostate cancer. The remaining three low anterior (RaLAR) after For surgery, da Vinci Xi...
Tauopathies are neurodegenerative diseases characterized by abnormal metabolism of misfolded tau proteins and progressive. Pathological phosphorylation occurs in the retinal ganglion cells (RGCs) after optic nerve injuries. Cyclin-dependent kinase-5 (Cdk5) causes hyperphosphorylation tau. To determine roles played Cdk5 degeneration, roscovitine, a inhibitor, was injected intravitreally crush (ONC). The neuroprotective effect roscovitine determined number Tuj-1-stained RGCs on day 7. change...
Dyskeratosis congenita (DKC) is a rare, multisystem, bone marrow failure disease characterized by abnormalities such as in the skin, mucosa, nervous system, and lungs. Here we report rare case of presumed DKC causing total retinal detachment right eye severe peripheral vascular occlusion left eye. A 3-year-old boy was presented with vitreous hemorrhage scheduled to undergo surgery detailed ophthalmologic examination under general anesthesia. Since systemic revealed anemia marked...
Inflammatory myofibroblastic tumor (以下, IMT) は肺を好発部位とする腫瘤であるが, 下部消化管に発生することは非常にまれである. 今回, 急速に増大し, 悪性腫瘤との鑑別が困難であった虫垂原発のIMTを経験したので報告する. 症例は58歳の男性で, アルコール性肝硬変にて当院内科通院中, 右下腹部の腫瘤を触知, その後腫瘍の増大傾向が認められ入院精査となった. CTにて盲腸から背側に虫垂と一塊になった造影効果を伴う腫瘤を認めたが, 下部消化管内視鏡検査にて盲腸が下方から壁外性に圧排されているのみで腫瘍性病変は認めなかった.また, 注腸造影X線検査にて上行結腸から盲腸にかけ多発する憩室を認め, 盲腸は変形していた. 以上より, 盲腸周囲の炎症性変化を疑うが, 増大傾向があり悪性腫瘍も否定できず, 腹腔鏡下回盲部切除術を施行, 病理組織学的検査にてIMTと診断された.
Vascular endothelial growth factor (VEGF) influences colorectal cancer (CRC) progression and is a key target in the treatment for metastatic CRC. However, oncological impact of preoperative circulating VEGF non-metastatic CRC (non-mCRC) has not been clearly elucidated. Herein, we have investigated prognostic significance elevated serum concentration curatively resected non-mCRC without neoadjuvant therapy.A total 474 patients with pStage I-III who underwent curative resection therapy were...