A5075179549- Esophageal and GI Pathology
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Breast Cancer Treatment Studies
- Esophageal Cancer Research and Treatment
- Thermal Regulation in Medicine
- Nutrition and Health in Aging
- Cerebrovascular and Carotid Artery Diseases
- Childhood Cancer Survivors' Quality of Life
- Minimally Invasive Surgical Techniques
- Adipose Tissue and Metabolism
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Thyroid and Parathyroid Surgery
- Metal Forming Simulation Techniques
- Cerebrospinal fluid and hydrocephalus
- Abdominal vascular conditions and treatments
- Gastrointestinal Tumor Research and Treatment
- Neurological Disease Mechanisms and Treatments
- Infectious Aortic and Vascular Conditions
Nagoya City University
2024
Mizuho (Japan)
2024
Fujimoto Pharmaceutical Corporation (Japan)
2021-2023
Kariya Toyota General Hospital
2023
Nagoya City University Hospital
2023
National Cancer Center Hospital East
2022
Juntendo University
2022
Nagoya Medical Center
2017-2020
Saiseikai Kumamoto Hospital
2016
Yamaguchi University
1991-1993
The purpose of the present study is to determine effect mild hypothermia on synthesis ubiquitin, an important protein for maintenance cell viability, in hippocampal neurons following transient cerebral ischemia.Transient ischemia was induced by occluding both common carotid arteries 5 minutes. In experiment 1, animals were divided into four groups according rectal and scalp temperatures during ischemia: normothermia group graded A, B, C (n = 9 per group). CA1 neuronal density assessed at 7...
Abstract Elevated autophagy activity enhances the malignancy of pancreatic cancer (PaCa), and is recognized as a novel therapeutic target. Zinc finger protein with KRAB SCAN domains 3 (ZKSCAN3) transcription factor that suppresses autophagy, but its association PaCa unknown. We analyzed function ZKSCAN3 in investigated whether regulation through could become new target for PaCa. Using reverse transcription‐quantitative polymerase chain reaction western blotting, we observed expression was...
We previously established pancreatic cancer (PaCa) cell lines resistant to gemcitabine and found that the activity of nuclear factor κB (NF-κB) was enhanced upon acquisition resistance. Parthenolide, main active ingredient in feverfew, has been reported exhibit antitumor by suppressing NF-κB signaling pathway several types cancers. However, effect parthenolide on gemcitabine-resistant PaCa not elucidated. Here, we confirmed significantly inhibits proliferation both normal cells at...
Abstract The area of residual tumor (ART) is a prognostic factor in patients treated with neoadjuvant chemotherapy (NAC) for lung, pancreatic, and rectal cancers. This study aimed to evaluate the usefulness ART as method predicting prognosis triple‐negative breast cancer (TNBC) after NAC. We included 143 TNBC at maximum cut surface was measured. divided into three groups: ART‐0 (ART = 0 mm 2 ), ART‐low (0 < ≤ 136mm ART‐high > 136 compared their clinicopathologic factors prognosis....
Abstract Purpose The aims of the present study were to investigate symptom clusters in terminally ill patients with cancer using European Organization for Research and Treatment Cancer Quality Life Questionnaire Core 15 Palliative Care (EORTC QLQ-C15-PAL), examine whether these influenced prognosis. Methods We analyzed data from 130 hospitalized palliative care unit June 2018 December 2019 an observational study. Principal component analysis was used detect scored date 14 items QLQ-C15-PAL,...
The clinical use of patient-reported outcomes as compared to inflammatory biomarkers for predicting cancer survival remains a challenge in palliative care settings. We evaluated the role European Organization Research and Treatment Cancer Quality Life Questionnaire Core 15 Palliative scores (EORTC QLQ-C15-PAL) C-reactive protein (CRP), albumin (Alb), neutrophil-lymphocyte ratio (NLR) prediction patients with advanced cancer.This was an observational study terminally ill hospitalized unit...
With advances of combined modality therapy, prognoses in esophageal cancer have been improving. After resection cancer, the development gastric tube is a risk. While such an early stage can be cured endoscopically, total indicated advanced stages. A 68-year-old man underwent subtotal esophagectomy reconstructed with through retrosternal route. Gastric was found one and half years postoperatively. The resected without sternotomy. This first report patient undergoing route
Background: Few studies evaluated whether health care professionals accurately assess several symptoms for patients with cancer in palliative units. We determined the agreement level related to quality of life (QOL) between patient-reported QOL assessment and professional-assessed based on Support Team Assessment Schedule (STAS). Method: An observational study was performed terminally ill hospitalized unit June 2018 December 2019. Patients independently assessed 7 at time hospitalization...
Abstract The use of laparoscopic surgery has become widespread in recent years. One its complications is port site hernia (PHS). It can be difficult to close the fascia at time laparoscopy, especially obese patients, and there a risk herniation through fascial defect with incomplete closure. important ascertain closure when repairing PHS prevent recurrence. We report 47-year-old woman who developed superior aspect umbilicus. repaired using VersaOneTM Fascial Closure System guidance. This...
Patients with esophageal cancer frequently cannot tolerate thoracotomy due to their overall debilitated condition. Moreover, some patients have severe adhesions in the thoracic cavity. Eversion stripping of esophagus is an option for resection these patients. A 64-year-old man was admitted our institution chief complaint epigastric pain. Endoscopic examination showed a protruding lesion 22 cm from incisors, superficial and circumferential mucosal irregularity on distal side lesion. Biopsy...
Pregnant Wistar rats were divided into 3 groups, non-operated control, adrenalectomized, and adrenalectomized corticosterone-treated. Maternal adrenalectomy was performed on day 6 of gestation. Corticosterone therapy made from the at operation to observation. The growth pattern insulin-producing B-cells observed immunohistochemically histometrically days 12 16. results obtained as follows: From 15, maternal resulted in a significant retardation insulin-positive terms collective volume cells....
終末期における抗がん治療の現状を知り緩和ケア病棟（PCU）の意義を検討する目的で，2013年10月からの2年間に当院で死亡したがん患者414例（PCU 219例，一般病棟195例）を対象に，抗がん治療歴や緩和ケア状況を検討した．その結果，一般病棟ではPCUに比べ高齢で，診断が遅く，病勢進行が速い患者が多く，これらが標準的な抗がん治療や緩和ケアの機会を妨げる要因となった可能性が示唆された．一方，化学療法施行例においては，最終治療日から死亡までの中央値がPCU 110日に対し一般病棟は55日と有意に短く，死亡前1カ月間の化学療法施行率もPCU 2％に対し一般病棟は32％と高率であった．終末期の抗がん治療を適正化する上でPCUの意義は大きいと考えられたが，診断時期や病勢進行速度にかかわらず早期からの緩和ケアを実践するには，社会全体に向けた緩和ケアやアドバンスケアプランニングの普及啓発が大切である．
Thyroids of 15-day rat fetuses prior to culture had no follicles. After 2 days in culture, regardless added TSH the medium, thyroids small, colloid-storing In follicular cells, rER and Golgi apparatus were somewhat well developed as compared with culture. 17-day first inlaid With TSH, 2-day cultures showed a more marked dilation further development than those without TSH. These results indicate electron microscopically that has effect on formation follicles initial but can promote cells...
Background: Prognostics for patients with cancer is especially important the supportive care of those who are terminally ill. We previously found that symptom scores as patient-reported outcomes (PROs)—such dyspnea and fatigue scores—some biochemical parameters, palliative performance scale (PPS) scores, clusters were useful prognostic factors; however, predictability a prognosis based on these factors remains unclear. Objective: To identify appropriate three-week survival predictive...
症例は59歳,女性.交通外傷にて救急搬送となった.来院時,血圧およびSpO2の低下,左呼吸音の減弱を認めた.CTで胃,横行結腸,肝外側区の左胸腔内への逸脱を認めた.横隔膜損傷による外傷性横隔膜ヘルニアと診断し,手術を施行した.開腹すると,左横隔膜に長径12cmの欠損を認めた.脱出臓器は容易に腹腔内に引き出すことが可能であり,虚血性変化や損傷は認めなかった.胸腔内を観察すると,横隔膜損傷に加え,心膜損傷を伴い,それぞれ連続縫合にて閉鎖した.外傷性横隔膜損傷は多数臓器損傷を合併していることが多いとされるが,外傷性横隔膜損傷に伴う心膜損傷は稀である.解剖学的に,横隔膜と心膜は連続した組織であり,心嚢底部において両者は癒合している.横隔膜損傷例においては,本症例のように横隔膜から心膜へと連続する裂傷が生じ得ることを念頭に置く必要がある.
In the present study we evaluated cerebrovascular reserve capacity (CRC) during temporal occlusion of internal carotid artery (Matas test) as a preoperative test in selection candidates for permanent ligation from among patients with cavernous giant aneurysms. Cerebral blood flow (CBF) rest (resting CBF), Matas (Matas-CBF), and after administration 1g acetazolamide (acetazolamide-Matas-CBF) were measured using stable xenon-enhanced CT CBF technique (Xe-CT). This procedure was named...