A5014108501- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- Antimicrobial Resistance in Staphylococcus
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Gastroesophageal reflux and treatments
- Diet, Metabolism, and Disease
- Renal cell carcinoma treatment
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ion Transport and Channel Regulation
- Advanced Wireless Communication Techniques
- Alcohol Consumption and Health Effects
- Cancer Mechanisms and Therapy
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
Tokushima University
2015-2025
Shizuoka Cancer Center
2024-2025
Takarazuka City Hospital
2018-2025
Hyogo Prefectural Cancer Center
2007-2025
Kobe University Hospital
2005-2025
Kōchi University
2025
Showa University Hospital
2020-2024
Osaka University of Pharmaceutical Sciences
2021-2024
Kawasaki Medical School
2004-2023
Kishiwada Tokushukai Hospital
2019-2023
Abstract Plants synthesize a sulfur-containing lipid, sulfoquinovosyldiacylglycerol, which is one of three nonphosphorus glycerolipids that provide the bulk structural lipids in photosynthetic membranes. Here, identification novel gene, UDP-glucose pyrophosphorylase3 (UGP3), required for sulfolipid biosynthesis described. Transcriptome coexpression analysis demonstrated highly correlated expression UGP3 with known genes Arabidopsis thaliana. Liquid chromatography–mass spectrometry leaf two...
We evaluated clinical factors related to improved prognosis of unresectable hepatocellular carcinoma patients (u-HCC), who were treated with tyrosine kinase inhibitor (TKI) sequential therapy, including lenvatinib (LEN).We enrolled 84 u-HCC cases TKIs LEN from March 2018 January 2019 (median age 71 years, 63 males, Child-Pugh score (CPS) 5/6/7 = 62/21/1, tumor-node-metastasis stage Liver Cancer Study Group Japan 6th (TNM-LCSGJ) II/III/IVa/IVb 12/30/5/37, Barcelona Clinic B/C 33:51). Clinical...
// Tetsu Tomonari 1 , Shunsaku Takeishi Tatsuya Taniguchi Takahiro Tanaka Hironori Shota Fujimoto Tetsuo Kimura Koichi Okamoto Hiroshi Miyamoto Naoki Muguruma Tetsuji Takayama Department of Gastroenterology and Oncology, Institute Biomedical Sciences, Tokushima University Graduate School, City, 770-8503, Japan Correspondence to: Takayama, e-mail: takayama@tokushima-u.ac.jp Keywords: hepatocellular carcinoma, sorafenib, resistance, transporter, MRP3 Received: September 30, 2015 Accepted:...
Introduction: Lenvatinib (LEN) is a novel potent multi-tyrosine kinase inhibitor, approved as first-line treatment for unresectable hepatocellular carcinoma (HCC). Considering its high objective response rate, LEN therapy could be expected to achieve downstaging of tumors and lead conversion with hepatectomy or ablation. However, the feasibility after in HCC remains largely unknown. Patient concerns: Here, we reported 3 cases HCC: case 1, 69-year-old man diagnosed ruptured HCC; 2,...
This retrospective multicenter study analyzed 244 patients with unresectable hepatocellular carcinoma treated lenvatinib (LEN) and atezolizumab + bevacizumab (Atezo Bev) to examine the characteristics, treatment courses, prognoses. The cases of who could achieve HCC downstaging from Barcelona Clinic Liver Cancer (BCLC) stage B or C A zero indicated need for conversion therapy. patients’ prognoses without therapy were compared. Of patients, 12 (4.9%) underwent therapy, six out 131 (4.6%) LEN,...
Various vaccine treatments against metastatic colorectal cancer have been developed and applied. However, to improve the efficacy of immunotherapy, biomarkers that can predict effects are needed. It has reported various microRNAs (miRNAs) in peripheral blood may be useful as non-invasive biomarkers. In this study, miRNAs influencing treatment were screened for a microarray analysis 13 plasma samples obtained from patients prior treatment. To validate screening results, real-time RT-PCR was...
Précis: Micropulse cyclophotocoagulation (MPCP) lowered intraocular pressure (IOP) in the short-term but nearly half required additional intervention. Mydriasis was most common complication (11%); 15% lost ≥3 Snellen lines of acuity; 11% had persistent complications at last follow-up. Purpose: The purpose this study to evaluate efficacy and MPCP a large series patients with all stages glaucoma. Design: Multicenter, retrospective chart review from 3 clinical sites. Participants: One hundred...
Abstract Background Although proton pump inhibitors (PPIs) or potassium-competitive acid blocker (PCAB) are useful in peptic ulcer prevention, their efficacy preventing other gastrointestinal bleeding remains unclear. This study aimed to identify the status of modern era when PPIs widely used. Methods included patients who underwent percutaneous coronary intervention (PCI) between 2018 and 2019 at two high-volume centers. Patients were categorized based on whether they experienced within 2...
Many clinical trials of peptide vaccines have been conducted. However, these provided benefits in only a small fraction patients. The purpose the present study was to explore microRNAs (miRNAs) as novel predictive biomarkers for efficacy vaccine treatment against colorectal cancer. First, we carried out microarray analysis pretreatment cancer tissues phase I study, which alone were given. Candidate miRNAs selected by comparison better prognosis group with poorer group. Next, conducted II...
Background: Opioids are known to induce delirium, and the incidence of delirium induced by individual opioids has been investigated. However, only a limited number studies have examined oral hydromorphone. Objective: To investigate whether differences exist in associated with morphine hydromorphone during initiation phase treatment. Methods: The participants were opioid-naive inpatients cancer who started or at Shizuoka Cancer Center (in Shizuoka, Japan) between June 2017 November 2020....
Myxofibrosarcoma is one of the most prevalent histological types primary malignant soft tissue tumors extremity. Radiation therapy frequently employed as a post-operative treatment. In this case report, we present 78-year-old male with large tumor on his forearm. He refused surgical Over period seven years, recurrence and bleeding were repeatedly observed. Kochi oxydol radiation for unresectable carcinomas (KORTUC) treatment modality that uses hydrogen peroxide solution adheres to surface...
Abstract Aim This study aimed to evaluate the impact of infusion timing time‐of‐day on clinical outcomes in patients with unresectable hepatocellular carcinoma (HCC) treated atezolizumab plus bevacizumab combination therapy. Methods A retrospective analysis was conducted using data from 751 HCC between September 2020 and April 2024. Patients were categorized into morning (AM; n = 351) afternoon (PM; 400) groups based time‐of‐day. Outcomes, including progression‐free survival (PFS), overall...
Abstract Aim This study aimed to evaluate the prognostic impact of muscle volume changes during atezolizumab‐bevacizumab (AB) combination therapy (AB therapy) for unresectable hepatocellular carcinoma (u‐HCC). Additionally, we evaluated whether in relate prognosis based on treatment response. Methods The present retrospective, multicenter included 165 patients with u‐HCC treated AB at eight institutions. Results median albumin–bilirubin score entire cohort was −2.42. objective response rate...
Background: Active hexose correlated compound (AHCC) is a“ complex compound” containing polysaccharides. AHCC has been reported to improve the prognosis of postoperative hepatocellular carcinoma patients. However, molecular mechanism this improvement not fully understood. In diseased liver, nitric oxide (NO) generated by inducible synthase (iNOS) considered be a causal factor for various hepatopathies. study, possibility regulation NO production iNOS was pursued as potential liver‐protecting...
The optimal choice between sorafenib (SOR) or lenvatinib (LEN) as the first-line treatment for unresectable hepatocellular carcinoma (u-HCC) remains debatable. Using propensity score matching, this study compares outcomes of SOR and LEN in molecular-targeted agent (MTA) sequential u-HCC patients.This retrospective, multicenter, observational recruited 137 patients who underwent primary with (n = 52) 85) June 2017 2020 after regorafenib was approved secondary u-HCC. Propensity matching used...
The mechanism of resistance to sorafenib in hepatocellular carcinoma (HCC) remains unclear. We analyzed miRNA expression profiles sorafenib-resistant HCC cell lines (PLC/PRF5-R1/R2) and parental (PLC/PRF5) identify the miRNAs responsible for resistance. Drug sensitivity, migration/invasion capabilities, epithelial-mesenchymal transition (EMT) properties were by biochemical methods. clinical relevance target genes survival patients assessed using a public database. Four significantly...
Abstract Aim We analyzed the association between modified albumin–bilirubin (mALBI) grade and therapeutic efficacy of atezolizumab plus bevacizumab (Atezo+Bev) for treatment unresectable hepatocellular carcinoma (u‐HCC). Methods In this retrospective observational study, we included 71 u‐HCC patients treated with Atezo+Bev September 2020 2021. Patients were grouped corresponding to mALBI at start (mALBI 1+2a or 2b+3) effect transition rate secondary treatment. Results According Response...
The efficacy and safety of lenvatinib (LEN) as a second/third-line treatment for unresectable hepatocellular carcinoma (HCC) after sorafenib (SOR) therapy remains unknown. We evaluated the outcomes LEN treatment, investigated sensitivity SOR-resistant HCC cell line (PLC/PRF5-R2) to LEN, assessed their signal transduction pathways by protein array analysis. retrospectively enrolled 57 patients with HCC. Fifty-three radiologically comprised 34 molecular-targeted agent (MTA)-naive (first-line),...
Recent evidence indicates that inhibition of the Na+/H+ exchanger improves heart and brain injuries induced by I/R. Studies were performed to investigate whether FR183998, a inhibitor, has protective effects on hepatic I/R injury in rats. Male Sprague-Dawley rats subjected 70% ischemia occluding artery, portal vein, bile duct associated with left median liver lobes microvascular clip for 2 h. FR183998 (1 mg/kg) was administered i.v. 10 min before ischemia. Hepatic increased serum levels...
In Japan, the number of elderly people who have difficulties performing activities daily living (ADLs) is increasing. The objective this study was to assess relationship between ADL and clinical characteristics pneumonia.We conducted a retrospective 219 adult patients hospitalized due pneumonia [151 with community-acquired (CAP) 68 healthcare-associated (HCAP)]. CAP, HCAP, all were stratified into two groups using modified version Katz index five ADLs as follows: independent in or dependent...