A5091570280- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- RNA regulation and disease
- Cancer-related gene regulation
- Infant Health and Development
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Digestive system and related health
- Probiotics and Fermented Foods
- Exercise and Physiological Responses
- Diagnosis and treatment of tuberculosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chemotherapy-related skin toxicity
Tokushima University
2014-2024
Institute of Biomedical Science
2016-2021
Tokyo Medical University Ibaraki Medical Center
2016-2021
Columbia University
2010-2011
Kochi University of Technology
2002
Hiroshima University
2000
Osaka University
1993
Stress-induced abdominal dysfunction is an attractive target for probiotics. To investigate the effects of probiotic Lactobacillus casei strain Shirota on dysfunction, a double-blind, placebo-controlled trial was conducted with healthy medical students undertaking authorized nationwide examination academic advancement. For 8 weeks, until day before examination, 23 and 24 subjects consumed L. Shirota-fermented milk placebo daily, respectively. In addition to assessments symptoms,...
Abstract Background This study aimed to examine the effects of Lactobacillus casei strain Shirota (LcS) on gut–brain interactions under stressful conditions. Methods Three double‐blind, placebo‐controlled trials were conducted LcS psychological and physiological stress responses in healthy medical students academic examination stress. Subjects received LcS‐fermented milk or placebo daily for 8 weeks prior taking a national standardized examination. Subjective anxiety scores, salivary...
Short-term administration of Lactobacillus gasseri CP2305 improves stress-associated symptoms and clinical in healthy young adults patients with irritable bowel syndrome, respectively. We evaluated the efficacy health benefits long-term use a tablet containing heat-inactivated, washed (CP2305) adults. Sixty Japanese medical students (41 men 19 women) preparing for national examination practitioners ingested CP2305-containing or placebo tablets once daily 24 weeks. Intake significantly...
This pilot study investigated the effects of probiotic Lactobacillus casei strain Shirota (LcS) on psychological, physiological, and physical stress responses in medical students undertaking an authorised nationwide examination for promotion. In a double-blind, placebo-controlled trial, 24 23 healthy consumed fermented milk containing LcS placebo milk, respectively, once day 8 weeks until before examination. Psychophysical state, salivary cortisol, faecal serotonin, plasma L-tryptophan were...
To confirm the stress‐relieving effects of heat‐inactivated, enteric‐colonizing Lactobacillus gasseri CP2305 (paraprobiotic CP2305) in medical students taking a cadaver dissection course. Healthy (21 males and 11 females) took paraprobiotic daily for 5 weeks during The General Health Questionnaire Pittsburgh Sleep Quality Index were employed to assess stress‐related somatic symptoms sleep quality respectively. aggravation stress‐associated was observed female (P = 0·029). improved group...
The present study examined whether Lactobacillus casei strain Shirota (LcS) improves sleep quality under psychological stress. A double-blind, placebo-controlled trial was conducted in healthy 4 th year medical students exposed to academic examination repeated over two consecutive years different groups of students, and the data were pooled. For 8 weeks prior 3 after a national standardised examination, total 48 46 subjects received daily dose 100 ml LcS-fermented milk or non-fermented...
Administration of Lactobacillus gasseri CP2305 for 4 weeks improved stress-associated behaviours in healthy young adults and clinical symptoms patients with irritable bowel syndrome. The present study was designed to confirm the stress-relieving effects heat-inactivated, washed (paraprobiotic CP2305) on 69 sixth-year medical students (40 males 29 females) preparing take national examination practitioners. paraprobiotic 12 significantly sleep quality assessed by both Pittsburgh Sleep Quality...
The heat-inactivated, enteric-colonizing Lactobacillus gasseri CP2305 (CP2305) ameliorates psychological stress-related symptoms. In this study, we examined effects of on top athletes experiencing physical and mental stresses. Forty-nine male university Ekiden (long distance relay race) runners daily took the CP2305-containing beverage for 12 weeks during training competing in All-Japan championships. intake significantly facilitated recovery from fatigue relieved anxiety depressive mood,...
Hu antigen R (HuR) regulates stress responses through stabilizing and/or facilitating the translation of target mRNAs. The human TRA2β gene encodes splicing factor transformer 2β (Tra2β) and generates 5 mRNA isoforms (TRA2β1 to -5) alternative splicing. Exposure HCT116 colon cancer cells sodium arsenite stimulated checkpoint kinase 2 (Chk2)- mitogen-activated protein p38 (p38(MAPK))-mediated phosphorylation HuR at positions S88 T118. This induced an association between 39-nucleotide (nt)...
Increasing recognition of the interaction between brain and gut microbiota has spurred interest in efficacy probiotics on stress-related behaviours. This study aimed to elucidate effects Lactobacillus gasseri CP2305 (CP2305) mental physical states healthy male students enrolled a cadaver dissection course double-blinded, placebo-controlled, crossover-designed trial. Daily administration for 4 weeks significantly improved anxiety, depressive mood global sleep quality compared with placebo....
The human TRA2B gene consists of 10 exons and 9 introns produces 5 splice isoforms (TRA2β1 to TRA2β5). exon 2 encodes multiple premature termination codons. TRA2β1 lacks is translated into a functional transformer 2β (Tra2β) protein, whereas TRA2β4 contains works as RNA. Overexpressed Tra2β ectopic expression may be oncogenic. We found that heterogeneous nuclear ribonucleoprotein (hnRNP)A1 hnRNPU interacted with 2. Minigene assays revealed hnRNPA1 facilitated inclusion 2, promoted its...
Caloric restriction (CR) is an effective method for prevention of age-associated diseases as well overweight and obesity; however, there controversy regarding the effects dieting regimens on behavior. In this study, we investigated two different regimens: repeated fasting refeeding (RFR) daily feeding half amount food consumed by RFR mice (CR). CR had approximate 20% reduction in intake compared with control mice. Open field, light-dark transition, elevated plus maze, forced swimming tests...
MicroRNAs (miRNAs) play key roles in regulation of cellular processes response to changes environment. In this study, we examined alterations miRNA profiles peripheral blood from 25 male medical students two months and days before the National Examination for Medical Practitioners. Blood obtained one month after examination were used as baseline controls. Levels seven miRNAs (miR-16, -20b, -26b, -29a, -126, -144 -144*) significantly elevated during pre-examination period association with...
Serine/arginine-rich splicing factors (SRSFs) play wide-ranging roles in gene expression through post-transcriptional regulation as well pre-mRNA splicing. SRSF7 was highly expressed colon cancer tissues, and its knockdown inhibited cell growth cells (HCT116) association with altered of 4,499 genes. The Ingenuity Pathway Analysis revealed that cycle-related canonical pathways were ranked the enriched category affected Western blotting confirmed p21, a master regulator cycle, increased...
A majority of early colorectal cancers ( CRC s) with submucosal invasion undergo surgical operation, despite a very low incidence lymph node metastasis. Our study aimed to identify micro RNA s (mi specifically responsible for metastasis in s. Micro microarray analysis revealed that miR‐100 and miR‐125b expression levels were significantly lower tissues metastases than those without metastases. These results validated by quantitative real‐time PCR larger set clinical samples. The transfection...
To clarify the effects of Lactobacillus gasseri CP2305 (CP2305) on quality life and clinical symptoms its functional mechanisms in patients with irritable bowel syndrome (IBS). After were administered daily for 4 weeks, IBS‐severity index score was significantly improved compared that placebo group, this improvement accompanied by a reduction health‐related worry changes intestinal microbiota. The gene expression profiling peripheral blood leucocytes showed treatment up‐regulated genes...