A5101548381- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Polyamine Metabolism and Applications
Tokushima University
2015-2024
Sakai Municipal Hospital
2010-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2023
ProQuest (United States)
2023
Toyonaka Municipal Hospital
2021
Kitamurayama Hospital
2015
Mitsubishi Group (Japan)
2004
Osaka University
1995-2001
Kobe University
1995
University of California, Berkeley
1995
<h3>Background</h3> After endoscopic submucosal dissection (ESD) of early gastric cancer (EGC), patients are at high risk for synchronous or metachronous multiple cancers. <h3>Objective</h3> To elucidate the time which cancers develop and to determine whether scheduled surveillance might control their development. <h3>Design</h3> A multicentre retrospective cohort study from 12 hospitals was conducted. Patients with EGC who underwent ESD en bloc margin-negative curative resection were...
Objective To evaluate the influence of low-dose, enteric-coated aspirin tablets (100 mg/day for 2 years) on colorectal tumour recurrence in Asian patients with single/multiple tumours excised by endoscopy. Design A double-blinded, randomised, placebo-controlled multicentre clinical trial was conducted. Participants 311 subjects adenomas and adenocarcinomas endoscopy were enrolled study (152 group 159 placebo group). Enrolment began at hospitals (n=19) 2007 completed 2009. Results The treated...
Background: Linked color imaging (LCI) is a new image-enhanced endoscopy technique that allows users to recognize slight differences in mucosal color. Objective: To compare the performance of LCI with white light (WLI) detecting neoplastic lesions upper gastrointestinal tract. Design: A controlled, multicenter trial randomization using minimization. (University Hospital Medical Information Network Clinical Trials Registry: UMIN000023863) Setting: 16 university hospitals and 3 tertiary care...
Background: Endoscopic submucosal dissection (ESD) was developed for en bloc removal of large and flat gastrointestinal tract neoplasms. In Japan, ESD is performed under conscious sedation. The risks sedation‐related complications ESD, such as postoperative pneumonia, have not been evaluated. aim this study to evaluate the incidence pneumonia after in a multicenter survey. Patients Methods: A total 1188 patients with upper gastric neoplasms treated nine hospitals were enrolled from May 2003...
Although new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color (LCI) have been developed, their utility for the detection of sessile serrated adenoma/polyps (SSA/Ps) is still unclear. This study aimed to evaluate BLI, LCI SSA/P in image examinations a prospective randomized controlled trial (RCT). A group 6 expert non-expert endoscopists read 200 endoscopic images containing lesions using white light (WLI), LCI. Color differences were...
Background and aims Psychologic stress can affect the pathogenesis of inflammatory bowel disease (IBD), but precise contribution psychologic to IBD remains unclear. We investigated association with activity in patients IBD, especially terms mental state sleep condition. Methods This was a multi-center observational study comprising 20 institutions. Data were collected using survey forms for doctors questionnaires patients, clinical parameters investigated. Mental evaluated Center...
Objectives. Heparin replacement (HR) is often performed in patients with a high risk of thrombosis undergoing endoscopic procedures. However, information about the influence HR scarce. The aim this study to assess clinical impact for gastric submucosal dissection (ESD). Methods. This retrospective comprising approximately 1310 consecutive neoplasms 1250 patients, who underwent ESD 5 institutes. We assessed findings and outcomes under HR, compared without as control. Results. A total 24 EGC...
Endoscopic submucosal dissection (ESD), which provides a higher en bloc resection rate than conventional endoscopic mucosal (EMR), is considered to be useful treatment option for large colorectal tumors. However, ESD not widely used because of its technical difficulty, risk complications and time required. To overcome these drawbacks, simpler modified technique, with snaring (hybrid ESD), has been developed. The aim the present study was retrospectively compare safety efficacy hybrid...
Abstract Background We developed a machine learning (ML) model to predict the risk of lymph node metastasis (LNM) in patients with early gastric cancer (EGC) who did not meet existing Japanese endoscopic curability criteria and compared its performance that most common clinical scoring system, eCura system. Methods used data from 4,042 consecutive EGC 21 institutions underwent submucosal dissection (ESD) and/or surgery between 2010 2021. All resected EGCs were histologically confirmed...
It has been reported that eradication of Helicobacter pylori improves fold width in H associated enlarged gastritis. The aim this study was to clarify the mechanism thickening condition.In eight patients with gastritis and 13 without folds, presence infection, inflammatory infiltrates, mucosal plasia, epithelial cell proliferation body mucosa were investigated, production transforming growth factor alpha (TGF alpha), hepatocyte (HGF), interleukin 1 beta (IL beta) determined by a competitive...
The antitumor activity of pladienolide B, a novel splicing inhibitor, against gastric cancer is totally unknown and no predictive biomarker B efficacy has been reported. We investigated the its derivative on cell lines primary cultured cells from carcinomatous ascites patients. effect six was using MTT assay mean IC50 values determined to be 1.6 ± 1.2 (range, 0.6-4.0) 1.1 0.4-3.4) nM, respectively, suggesting strong cancer. value 12 patients 4.9 4.7 indicative high activity. When 18 SCID...
Objective evaluation of intestinal mucosal damage due to anticancer drugs is generally difficult. Serum diamine oxidase (DAO) activity reported reflect the integrity and maturity small mucosa. Therefore, we investigated whether serum DAO an indicator gastrointestinal toxicity or nutritional status in patients receiving chemotherapy.We prospectively enrolled 20 with unresectable metastatic gastric cancer who received oral S-1 (80 mg/m(2) ) on days 1-14, intravenous cisplatin (60 docetaxel (50...
Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation in aberrant crypt foci (ACF), SSA/P, specimens to show close association between ACF SSA/P-cancer sequence. also evaluated prevalence number patients.ACF right-side were observed 36 patients SSA/Ps alone, 2 cancers 20 normal subjects biopsied under...
A majority of early colorectal cancers ( CRC s) with submucosal invasion undergo surgical operation, despite a very low incidence lymph node metastasis. Our study aimed to identify micro RNA s (mi specifically responsible for metastasis in s. Micro microarray analysis revealed that miR‐100 and miR‐125b expression levels were significantly lower tissues metastases than those without metastases. These results validated by quantitative real‐time PCR larger set clinical samples. The transfection...
Whether Helicobacter pylori eradication prevents metachronous recurrence after endoscopic resection (ER) of early gastric cancer remains controversial. This multicenter retrospective study aimed to evaluate the long-term (> 5 years) effects H. by stratifying patients' baseline degrees atrophic gastritis.A total 483 pylori-positive patients who had undergone ER for were divided into two groups-(i) those having successful within 1 year (eradicated group, n = 294) and (ii) with failed or not...
The present study was designed to clarify whether bel-xL is involved in the development of carcinoma stomach. Levels and bc1-2 mRNA were determined by a reverse-transcription/polymerase-chain reaction endoscopic gastric biopsy specimens from 10 control subjects, 11 patients with adenomas 14 carcinomas. In 6 adenomas, 5 8 early carcinomas 3 advanced carcinomas, gene over-expressed. overexpression observed 9 intestinaltype 2 diffuse-type No correlation between expression. cases which...
Data on the long-term outcomes of endoscopic submucosal dissection (ESD) performed in elderly patients with early colorectal cancer (CRC) are limited. We analyzed prognosis CRC patients, not only from viewpoint treatment curability but also patients' baseline physical condition assessed by several indexes.A retrospective analysis 729 aged ≥75 years who underwent ESD for Tis/T1 16 institutions was conducted. The were classified into three groups based curability: curative (Group A, n = 582),...