A5102990304- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Neuropeptides and Animal Physiology
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Stress Responses and Cortisol
- Trace Elements in Health
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Fungal Plant Pathogen Control
- Memory and Neural Mechanisms
- Lymphoma Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- Contact Dermatitis and Allergies
- Biochemical effects in animals
Hyogo Prefectural Cancer Center
2016-2025
Japan Clinical Cancer Research Organization
2019
Takenaka (Japan)
2009-2015
Kyoto University Hospital
2012
National Cancer Center Hospital East
2012
Osaka International Cancer Institute
2012
Saitama Medical University
2011
Iwate Medical University
2011
Kumamoto University Hospital
2011
Okayama University Hospital
2011
Background & AimsEsophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma (ESCC). We conducted a single-arm prospective study to confirm efficacy and safety of selective chemoradiotherapy (CRT) based on findings from endoscopic resection (ER).MethodsWe performed patients with T1b (SM1–2) N0M0 thoracic ESCC December 2006 through July 2012; 176 underwent ER. Based ER, received following: no additional pT1a tumors negative margin lymphovascular invasion (group A);...
Objectives A Japanese multicenter prospective cohort study examining endoscopic resection ( ER ) for early gastric cancer EGC has been conducted using a Web registry developed to determine the short‐term and long‐term outcomes based on absolute expanded indications. We hereby present of this study. Methods All consecutive patients with or suspected undergoing at 41 participating institutions between July 2010 June 2012 were enrolled prospectively registered into registry. The baseline...
Early detection of gastric cancer has been the topic major efforts in high prevalence areas. Whether advanced imaging methods, such as second-generation narrow band (2G-NBI) can improve early detection, is unknown.This open-label, randomised, controlled tandem trial was conducted 13 hospitals. Patients at increased risk for were randomly assigned to primary white light (WLI) followed by secondary 2G-NBI (WLI group: n=2258) and WLI (2G-NBI n=2265) performed same examiner. Suspected (EGC)...
// Tomonori Yano 1 , Hiroi Kasai 2 Takahiro Horimatsu 3 Kenichi Yoshimura 4 Satoshi Teramukai 5 Morita Harue Tada Yoshinobu Yamamoto 6 Hiromi Kataoka 7 Naomi Kakushima 8 Ryu Ishihara 9 Hajime Isomoto 10 Manabu Muto Department of Gastroenterology, Endoscopy division, National Cancer Center Hospital East, Kashiwa, Japan Institute for Advancement Clinical and Translational Science, Kyoto University Hospital, Kyoto, Therapeutic Oncology, Graduate School Medicine, University, Innovative Research...
Abstract Background Photodynamic therapy (PDT) is a less invasive and effective salvage treatment for local failure after chemoradiotherapy (CRT) esophageal cancer, however it causes high rate of skin phototoxicity requires long sun shade period. Talaporfin sodium rapidly cleared photosensitizer that expected to have phototoxicity. This study was undertaken clarify the optimum laser fluence PDT using talaporfin diode patients with CRT or radiotherapy (RT) cancer. Methods phase I, dose...
Journal Article Tissue fibronectin is an endogenous ligand for galectin-1 Get access Yasuhiro Ozeki, Ozeki 1Division of Biomedical Polymer Science, Institute Comprehensive Medical Fujita Health UniversityToyoake, Aichi 470-11, Japan Search other works by this author on: Oxford Academic PubMed Google Scholar Taei Matsui, Matsui Yoshinobu Yamamoto, Yamamoto 3Department Clinical Immunology, University CollegeToyoake, Masanori Funahashi, Funahashi 2Department Pathology, School Jiharu Hamako,...
Inhibition of tumor promoter-induced Epstein-Barr virus (EBV) activation was screened using tissue culture and thallus extracts lichens. Usnea longissima ACH. Cetraria ornata MULL. ARG. showed strong inhibitory activity. We identified (+)-usnic acid (1), barbatic (2), diffractaic (3), 4-O-demethylbarbatic (4), evernic (5) as inhibitors EBV from the U. thallus. Of these compounds, exhibited highest activity (IC50 = 1.0 microM).
Distinguishing between mucosal and submucosal cancers is important for selecting the optimal treatment patients with esophageal squamous cell carcinoma (ESCC); however, standard procedures diagnosing cancer invasion depth have not yet been determined.To evaluate diagnostic performance of endoscopic ultrasonography (EUS) after conventional endoscopy evaluation ESCC depth.This prospective single-arm confirmatory study comprising 372 T1 was conducted at 41 secondary or tertiary hospitals in...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalonines related compoundsShosuke Ito, Shigeki Inoue, Yoshinobu Yamamoto, Keisuke FujitaCite this: J. Med. Chem. 1981, 24, 6, 673–677Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://pubs.acs.org/doi/10.1021/jm00138a006https://doi.org/10.1021/jm00138a006research-articleACS PublicationsRequest reuse...
AbstractTo explore the role of mPer2 in circadian oscillation mammalian cellular clock, we established fibroblast cell lines which expression is controlled through a tetracycline-regulatable promoter. We revealed that constitutive and overexpression mRNA severely impair serum shock-induced cyclic clock gene expression. Moreover, under conditions lower expression, mPER2 protein accumulation these cells showed clear even suggesting cycling was required for feedback loop. Since rhythms driven...
The goal of the study was to evaluate efficacy and safety balloon-occluded transarterial chemoembolization (B-TACE) hepatocellular carcinoma (HCC) using miriplatin (a lipophilic anticancer drug) gelatin particles.B-TACE performed for 62 HCC nodules in 33 patients who could not be treated by surgical resection or radiofrequency ablation. All had a history (TACE) treatment prior B-TACE. As historical comparison, we investigated 40 28 TACE conventional microcatheter (C-TACE), particles....
We have isolated a serine protease, halystase, from Agkistrodon halys blomhoffii venom by chromatography on DEAE‐Sepharose, heparin‐Sepharose and Q‐Sepharose columns, determined the complete amino acid sequence Edman degradation mass spectral analysis of peptides generated enzymatic chemical cleavage. The 238‐residue containing N‐linked carbohydrates (about 13 %) at two sites showed significant similarity to other thrombin‐like snake proteases (66−72 %), mammalian tissue kallikrein (42...
Background . Delayed perforation is a rare but severe complication of endoscopic submucosal dissection (ESD) for early gastric neoplasm (EGN). The aim this study was to clarify clinical factors related delayed after ESD. Methods A total 1158 consecutive patients with 1199 EGNs underwent ESD at our hospital between January 2000 and December 2015. Univariate analysis used identify clinicopathological perforation. Moreover, duration cautery needed hemostasis measured by comparison perforated...
In Japan, South Korea, and Taiwan, nivolumab might provide overall survival benefits for patients with advanced gastric cancer. However, it is effective only in a limited number of patients. The Glasgow prognostic score an indicator the systematic inflammatory response nutritional status. This study aimed to investigate ability other markers predict outcomes treated nivolumab. We reviewed medical records cancer who received between February 2015 June 2019 at Hyogo Cancer Center. were...
Single endoscopic examination often misses early gastric cancer (GC), even when both high-definition white light imaging and narrow-band are used. It is unknown whether new GC can be detected approximately 1 year after intensive index examination.To examine using imaging.This case-control study was a preplanned secondary analysis of randomized clinical trial involving 4523 patients with high risk who were enrolled between October 1, 2014, September 22, 2017. Data analyzed from December 26,...
Abstract Background and Aim Perforation is one of the most important complications endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Several studies have examined risk factors intraoperative delayed perforations, but were retrospective analyses with small numbers patients. Methods This study represents a secondary analysis Japanese multicenter prospective cohort study. We investigated associated each type perforation using 9015 patients 9975 EGCs undergoing ESD between...
1. The pharmacological properties of a benzodiazepine receptor (BZR) partial agonist, Y-23684 were investigated in comparison with those diazepam, conventional BZR full agonist. 2. and diazepam showed high selective affinity for the Ki values 41 5.8 nM, respectively. 3. In contrast to variability was noted anticonvulsive potency depending on convulsants (bicuculline, pentylenetetrazol maximal electrical shock). produced most potent protective effect against bicuculline rats mice ED50S 1.3...
Tiadinil is a novel systemic fungicide for rice diseases discovered and developed by Nihon Nohyaku Co., Ltd. The compound characterized unique heterocyclic moiety, 1,2,3-thiadiazole, mode of action inducing the plant defense mechanism against pathogen. lead was found in synthesis research 1,2,3-thiadiazole chemistry with appropriate screening system. Both application methods, nursery box into-water applications, can be used cultivation. It shows excellent activity blast also exhibits some...