A5064775282- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Gastroesophageal reflux and treatments
- Colorectal Cancer Treatments and Studies
- Dysphagia Assessment and Management
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- Neurofibromatosis and Schwannoma Cases
NTT Medical Center
2016-2025
The Japanese Society of Gastroenterological Surgery
2020-2023
Iwate Medical University
2020-2023
Hiroshima University Hospital
2023
Jikei University School of Medicine
2009-2020
Showa University
2020
Modbury Hospital
2019
The University of Adelaide
2019
State of The Art
2012
Optica
2012
Early detection of gastric cancer has been the topic major efforts in high prevalence areas. Whether advanced imaging methods, such as second-generation narrow band (2G-NBI) can improve early detection, is unknown.This open-label, randomised, controlled tandem trial was conducted 13 hospitals. Patients at increased risk for were randomly assigned to primary white light (WLI) followed by secondary 2G-NBI (WLI group: n=2258) and WLI (2G-NBI n=2265) performed same examiner. Suspected (EGC)...
Abstract Background Duodenal endoscopic submucosal dissection (ESD) remains technically challenging, with a high risk of severe adverse events. Because exposure the duodenal post-ESD mucosal defect to pancreatic juice and bile acid reportedly induces delayed perforation bleeding, we examined whether closure using an over-the-scope clip (OTSC) system was useful for preventing postoperative Methods From April 2016 February 2017, total 50 consecutive patients superficial non-ampullary...
Abstract Background Data on endoscopic resection (ER) for superficial duodenal epithelial tumors (SDETs) are insufficient owing to their rarity. There two main ER techniques SDETs: mucosal (EMR) and submucosal dissection (ESD). In addition, modified EMR techniques, such as underwater (UEMR) cold polypectomy, becoming popular. We conducted a large-scale retrospective multicenter study clarify the detailed outcomes of ER. Methods Patients with SDETs who underwent at 18 institutions from...
Endoscopic mucosal resection (EMR) is the gold standard for treatment of noninvasive large colorectal lesions, despite challenges associated with nonlifting lesions and a high rate local recurrence. submucosal dissection (ESD) offers possibility overcoming these EMR limitations. However, higher risk complications longer procedure time prevented its dissemination. As ESD now provides more stable results because standardized techniques compared those used earlier, this study aimed to quantify...
Bleeding after endoscopic submucosal dissection (ESD) is a severe adverse event. Recent reports have described the efficacy of shielding method with polyglycolic acid (PGA) sheets and fibrin glue for prevention events ESD. The aim present study was to investigate whether PGA provides additional benefit in preventing post-ESD bleeding compared standard care.This prospective, multicenter, randomized controlled trial. Patients at high risk were enrolled study. Before ESD, patients either group...
Although colorectal endoscopic submucosal dissection (ESD) is superior to mucosal resection (EMR) in en bloc rate, it technically quite difficult because of the anatomical and histological characteristics wall. This difficulty prevents wide spread technique. Establishment training system for ESD necessary standardize achieve wider acceptance this Herein, we describe our ESD, assess validity based on clinical outcomes learning curve trainees. Our would help procedure.
<b>Background and study aims: </b>A standard training system for endoscopic submucosal dissection (ESD) remains to be established. In this study, we evaluated the validity of our program gastric ESD. <b>Patients methods:</b> Four trainees performed ESD a total 117 lesions in 107 patients (27 30 consecutive per trainee) at tertiary referral center during 2 years program. Trainees, who already had fundamental skills knowledge needed ESD, each assisted 40 procedures, then 20 cases applied...
The primary purpose of this questionnaire survey study was to determine the current status colorectal endoscopic submucosal dissection (ESD) in specialized Japanese referral centers before and after introduction a government-approved advanced medical treatment system; and, secondly, ESD other Asian centers.A total 1321 ESDs were performed 11 institutions including two outside Japan.Overall en-bloc resection, curative R0 perforation, delayed bleeding emergency surgery rates 95.4%, 89.1%,...
<b>Background and study aims:</b> Despite the clinical advantages of colorectal endoscopic submucosal dissection (ESD), an effective training system, especially for Western endoscopists, has been challenging to establish. Herein, we propose a novel program using ex vivo animal models evaluate learning curve ESD trainees without gastric experience. <b>Patients methods:</b> A total 80 lesions were prospectively collected removed by two novice operators. Before human procedures, they received...
To clarify molecular alterations in serrated pathway of colorectal cancer (CRC), we performed epigenetic and genetic analyses sessile adenoma/polyps (SSA/P), traditional adenomas (TSAs) high-methylation CRC. The methylation levels six Group-1 14 Group-2 markers, established our previous studies, were analyzed quantitatively using pyrosequencing. Subsequently, targeted exon sequencing 126 candidate driver genes examined that are associated with development. SSA/P showed high both frequent...
Sodium alginate (SA) solution has characteristic viscoelasticity. We aimed to determine efficacy and safety of 0.6% SA for submucosal injection during endoscopic dissection (ESD) in patients with localized neoplastic lesion the esophageal gastric mucosa.We conducted a randomized controlled study at six major hospitals Japan including 130 endoscopically mucosa eligible ESD. Patients were randomly assigned or 0.4% sodium hyaluronate (SH) group (control); ESD was performed using SA/SH. As...
Background & AimsCold snare polypectomy (CSP) has become the standard resection method for small colorectal polyps (<10 mm). Sessile serrated lesions (SSL) have low prevalence of advanced histology irrespective size, and thus could be amenable to CSP. In this study, we evaluated safety efficacy CSP SSLs ≥10 mm.MethodsBetween November 2018 January 2020, prospectively enrolled 300 consecutive patients who underwent 474 mm. To delineate SSL borders, indigo carmine chromoendoscopy and/or...
Limited information is available on the efficacy and safety of endoscopic resection (ER) gastric submucosal tumors (SMTs) in Japanese practice where ER for extremely popular.We conducted this study to elucidate current scenario SMTs practice. Patients (from 12 institutions) with who underwent were enrolled from first case until August 2020.We 117 patients 118 lesions. The number increased over years. mean tumor size was 20 ± 7.2 (8-40) mm. growth type primarily intraluminal (90%). wound...
Abstract Objectives Gastric cancer can be diagnosed even in patients long after Helicobacter pylori eradication. Most cases involve intramucosal lesions; however, some are invasive and require surgery. To clarify appropriate long‐term surveillance methods, this study compared gastric ≥10 <10 years Methods This retrospective multicenter included 14 institutions. We 377 with submucosal or deep invasion surgical endoscopic resection. Ordered logistic regression analysis was used to explore...
Endoscopic submucosal dissection (ESD) is a standard treatment for early gastrointestinal cancer, but carries risks of delayed bleeding and perforation. closure the post-ESD ulcer can reduce these [1]. We previously reported "clip with line pulley securing" (CLiPS) technique [2] [3] [4], simple cost-effective method that allows without scope reinsertion. Mucosa-to-mucosa may however result in dehiscence, particularly large mucosal defects. To address this limitation, we developed modified...