A5010476683- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- Oral and Maxillofacial Pathology
- Esophageal Cancer Research and Treatment
Juntendo University
2016-2025
Juntendo University Hospital
2010-2022
The Japanese Society of Gastroenterological Surgery
2020-2022
Jikei University School of Medicine
2019
Creative Research Enterprises (United States)
2016
Juntendo University Shizuoka Hospital
2016
Singapore-MIT Alliance for Research and Technology
2013
Kaohsiung Chang Gung Memorial Hospital
2013
Hôpital Saint Eloi
2013
Kyushu University
2001-2010
Colorectal endoscopic submucosal dissection (ESD) has become common in recent years. Suitable lesions for treatment include not only early colorectal carcinomas but also many types of precarcinomatous adenomas. It is important to establish practical guidelines which the preoperative diagnosis neoplasia and selection procedures are properly outlined, ensure that actual useful safe general hospitals when carried out accordance with guidelines. In cooperation Japanese Society Cancer Colon...
The Japan Gastroenterological Endoscopy Society developed the Guideline for Endoscopic Diagnosis of Early Gastric Cancer based on scientific methods. diagnosis early gastric cancer has been acknowledged as a useful and highly precise examination, its use become increasingly more common in recent years. However, level evidence this field is low, it often necessary to determine recommendations expert consensus only. This clinical practice guideline consists following sections provide current...
Despite recent advances in diagnosis and treatment, gastric carcinoma remains a major cause of death the world.The clinicopathologic profile 10,000 consecutive patients who underwent primary gastrectomy during 1962-1989 were reviewed prognostic factors influencing survival those with analyzed 7031 patients.Incidence for has increased steadily rate early exceeded that advanced period 1985-1989. Five-year 10-year rates 46.1% 35.2% 3868 carcinoma, 88.8% 77.3% 3163 respectively. In significantly...
An optimal treatment modality for patients with primary gastrointestinal lymphoma has not yet been established. This study aimed to elucidate the clinicopathologic features of this disease and influence therapeutic modalities on prognosis in Japanese patientsThe 455 were investigated retrospectively regarding time trends.This comprised 342 (75%) gastric lymphoma, 96 (22%) intestinal 17 (4%) both lymphoma. Two hundred thirty-one (51%) classified as having low-grade B-cell including 200...
Extragastrointestinal stromal tumor (EGIST) is a unique that occurs outside the gastrointestinal tract. EGIST shows c-kit expression and histologic appearance similar to those of (GIST). Most GISTs have gain-of-functional mutation gene, some platelet-derived growth factor receptor-alpha (PDGFRA) gene. However, frequency genes in EGISTs remains unclear. We examined clinicopathologic features, prognostic factors, PDGFRA 39 cases EGIST. Tumors with high mitotic counts (>or=5/50 power fields) or...
Only a few cases of gastric adenocarcinoma fundic gland type have been reported. Gastric with chief cell differentiation (GA-CCD) has recently reported as new variant adenocarcinoma. However, its clinicopathologic features are uncertain. To elucidate them, GA-CCDs exhibiting pepsinogen-I expression (10 lesions: Group A) and randomly selected adenocarcinomas differentiated (111 B) were evaluated in this study. Cell by MUC2, MUC5AC, MUC6, CD10, pepsinogen-I, H+/K+-ATPase chromogranin A,...
The clinicopathologic and immunohistochemical features of the primary gastric hepatoid adenocarcinomas still remain unclear.The authors evaluated 28 (HC) stomach on basis characteristic histologic resembling hepatocellular carcinoma, which were selected from 7200 cases carcinoma in their files. Additionally, 22 alpha-fetoprotein (AFP)-positive without (APC) also selected.The HC fell into following two groups: with AFP-positive tumor cells (Group 1; 15 cases) 2; 13 cases). Histologically,...
Abstract Background and Aim Magnifying endoscopy with narrow‐band imaging (ME‐NBI) has made a huge contribution to clinical practice. However, acquiring skill at ME‐NBI diagnosis of early gastric cancer (EGC) requires considerable expertise experience. Recently, artificial intelligence (AI), using deep learning convolutional neural network (CNN), remarkable progress in various medical fields. Here, we constructed an AI‐assisted CNN computer‐aided (CAD) system, based on images, diagnose EGC...
Gastric adenocarcinoma of the fundic gland (chief cell predominant type, GA-FG-CCP) was recently proposed as a new, rare variant gastric adenocarcinoma. The aim current study to evaluate endoscopic features GA-FG-CCP. A total 10 GA-FG-CCPs were included and evaluated retrospectively. clinicopathological lesions analyzed provide information diagnostic value. classified into two categories: submucosal tumor shape (60 %) flat or depressed type (40 %). Endoscopically, most common %), whitish...
Abstract Background VISION is a randomised, phase 4, open-label, parallel-group, multicentre study conducted in 33 centres Japan. The aim of this was to assess the long-term safety vonoprazan for maintenance treatment healed erosive oesophagitis versus lansoprazole. Methods Patients with endoscopically diagnosed were randomised 2:1 once-daily 20 mg or lansoprazole 30 mg, 4- 8-week healing phase. confirmed entered 260-week starting dose 10 15 mg. Primary endpoint change gastric mucosal...
Acid secretion inhibitors are associated with hypergastrinemia, which can lead to gastric mucosal changes. Potassium-competitive acid blockers, such as vonoprazan, more potent than proton pump inhibitors, but long-term safety data lacking.
Abstract BACKGROUND Few previous articles have analyzed the relation between infection with Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. METHODS Resected biopsied specimens from 237 patients were investigated for H. using hematoxylin eosin stain, modified Giemsa immunohistochemistry. These compared 29 chronic active gastritis, 33 peptic ulcers, 41 carcinoma. RESULTS was detected 145 (61%) lymphoma. The frequency positivity higher restricted to...
Abstract MUTYH is a mammalian DNA glycosylase that initiates base excision repair by excising adenine opposite 8-oxoguanine and 2-hydroxyadenine guanine, thereby preventing G:C to T:A transversion caused oxidative stress. Recently, biallelic germ-line mutations of have been found in patients predisposed recessive form hereditary multiple colorectal adenoma carcinoma with an increased incidence somatic the APC gene. In present study, systematic histologic examination revealed more spontaneous...
To clarify the potential for malignancy of Peutz-Jeghers polyposis, we investigated 75 gastrointestinal polyps resected surgically or endoscopically from seven patients with this syndrome.There were 19 in stomach, 18 duodenum, 22 small intestine, and 16 large these histologically composed 1 pyogenic granuloma, cancer adenoma, 2 adenomas, 71 polyps. Nine accompanied by an adenomatous component, and, addition, two showed a cancerous transformation stalk invasion. A total 12 neoplastic (16...