A5004751078- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related Molecular Pathways
- Cardiac Valve Diseases and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Coronary Interventions and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Kruppel-like factors research
- Bone health and osteoporosis research
- Cancer, Hypoxia, and Metabolism
- Renin-Angiotensin System Studies
- Elasticity and Material Modeling
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Transplantation: Methods and Outcomes
- Cell Adhesion Molecules Research
- Gastrointestinal disorders and treatments
Japanese Red Cross Fukuoka Hospital
2014-2024
Osaka University
1998-2024
Kyushu University Hospital
2023
Kyushu University
2001-2021
Yamaguchi Prefecture Central Hospital
2013-2021
Kumamoto University
2020
Kawasaki Hospital
2018
Japanese Red Cross Society, Japan
2016
Kyushu Institute of Technology
2014
Red Cross Hospital
2006-2013
Initial description of apolipoprotein (apo) E-deficient transgenic mice demonstrated the development severe hypercholesterolemia due to probable delayed clearance large atherogenic particles from circulation. Examination these foam cell accumulation in aortic root and pulmonary arteries by 10 weeks age. In present study, animals were fed either chow or a high-fat, Western-type diet examined at ages ranging 6 40 weeks. Gross examination dissection microscopy revealed predilection for lesions...
Abstract —Focal recruitment of monocytes and lymphocytes is one the earliest detectable cellular responses in formation lesions atherosclerosis. This localized accumulation leukocytes a multistep process which endothelium remains intact may regulate leukocyte by expressing specific adhesion molecules. To examine relationship molecule expression to initiation factors sites lesion formation, we analyzed vascular cell molecule-1 (VCAM-1), intercellular (ICAM-1), platelet–endothelial (PECAM-1)...
Objective— The present study was designed to clarify the morphological features of early human atherosclerosis and determine whether specific extracellular matrix proteoglycans play a role in atherogenesis. Methods Results— Step serial sections were obtained from right coronary arteries with no or atherosclerosis. Atherosclerosis classified into 4 grades according amount lipid deposition. Coronary Grade 0 showed diffuse intimal thickening (DIT) deposits. proteoglycans, biglycan decorin,...
Primary pulmonary hypertension is a fatal disease characterized by endothelial dysfunction, hypercontraction and proliferation of vascular smooth muscle cells (VSMCs), migration inflammatory cells, for which no satisfactory treatment has yet been developed. We have recently demonstrated that intracellular signaling pathway mediated Rho-kinase, an effector the small GTPase Rho, involved in pathogenesis arteriosclerosis. In present study, we examined whether Rho-kinase–mediated also rats....
Cyclooxygenase (COX) is a key enzyme in the synthesis of prostanoids. Two isoforms this have been identified: COX-1 and COX-2. Recent studies suggested that COX-2, but not COX-1, may play role colorectal tumorigenesis. In present study, we investigated expression COX-2 as well human hepatocellular carcinoma (HCC) tissues using immunohistochemistry immunoblotting. Forty-four surgically resected HCC with adjacent nontumorous livers (NTs), involving 17 cases chronic viral hepatitis 27...
Only a few cases of gastric adenocarcinoma fundic gland type have been reported. Gastric with chief cell differentiation (GA-CCD) has recently reported as new variant adenocarcinoma. However, its clinicopathologic features are uncertain. To elucidate them, GA-CCDs exhibiting pepsinogen-I expression (10 lesions: Group A) and randomly selected adenocarcinomas differentiated (111 B) were evaluated in this study. Cell by MUC2, MUC5AC, MUC6, CD10, pepsinogen-I, H+/K+-ATPase chromogranin A,...
Background/AIMS: Recurrence due to clinically undetectable intrahepatic metastasis and portal vein invasion of HCC cells is not 'uncommon' even in small HCCs. The present study investigated the relationship between these factors macroscopic types HCC. METHODS: Surgically resected 209 cases less than 3 cm diameter were examined. Macroscopically, divided into 'vaguely nodular type', 'single type with extranodular growth' 'confluent multinodular type'. RESULTS: None vaguely had or invasion,...
Wild-type p53 (wt-p53), a key protein in cell cycle regulation, inactivates the G1 cyclins through direct activation of p21Waf-1/Cip-1/Sdi-1. Persistent vascular smooth muscle (VSMC) proliferation following interventions hinders benefits these therapeutics. Using hemagglutinating virus Japan/liposome-mediated gene transfer method, we examined inhibitory effect overexpression exogenous wt-p53 on VSMC vitro and vivo. We assessed proliferative activity human cDNA-transduced bovine VSMCs by DNA...
Abstract: Background : Hepatocellular carcinoma (HCC) is generally considered a hypervascular tumor when visualized by angiography. However, small HCCs are not always found to be hypervascular. Methods To evaluate this, 50 ≤ 3 cm in diameter were studied. The tumors consisted of 16 well‐differentiated HCCs, 25 moderately differentiated and 9 that each mixture well‐ HCC. Results mean number portal tracts the was 34% surrounding nontumorous liver, few intratumoral arterioles seen. In contrast,...
Purpose: The purpose of this work was to compare dynamic MRI (D-MRI) with CT (D-CT) for the diagnosis peripheral cholangiocarcinoma (PCC) liver. Method: Twenty patients PCC underwent both D-CT and D-MRI during early, middle, delayed phase after contrast medium administration. findings from were compared those D-CT. Results: exhibited a similar tumoral enhancement pattern, more conspicuous on D-MRI. A wedge-like area tumor observed in 9 (45%) 11 (55%) Ductal dilatation found 13 (65%)...
The hedgehog (Hh) signaling pathway is activated in various types of cancer including pancreatic ductal adenocarcinoma. It has been shown that extremely low oxygen tension (below 1% O 2 ) found tumor tissue adenocarcinoma cells (PDAC) and increases the invasiveness PDAC. To investigate contribution Hh to hypoxia‐induced invasiveness, we examined how hypoxia affects activation In present study, three human PDAC lines were cultured under normoxic (20% or hypoxic (1% conditions. Hypoxia...
Thymidine phosphorylase (dThdPase) is the rate-limiting enzyme that metabolizes 5'-deoxy-5-fluorouridine (5'-dFUrd, doxifluridine), an intermediate metabolite of capecitabine, to active drug 5-fluorouracil (5-FUra), while dihydropyrimidine dehydrogenase (DPD) catabolizes 5-FUra inactive molecule. The susceptibility tumors fluoropyrimidines reported correlate with tumor levels these enzymes. To obtain some insight into types susceptible fluoropyrimidine therapy, we measured expression two...
Neovascularization is well known to occur in human atherosclerotic plaques; however, its pathophysiological roles, mechanisms, and stimuli atherogenesis still remain unclear. In this study, 525 tissue blocks of coronary artery obtained at autopsy from 48 patients ranging age 20 93 years old (mean+/-SD, 71+/-15 years) were immunohistochemically examined for vascular endothelial growth factor (VEGF) expression the intimas. The lesions histopathologically classified into types I through VI, as...
Rheumatoid arthritis (RA), a systemic inflammatory disease of unknown etiology, mainly affects synovial joints. Although angiogenic growth factors, including fibroblast factor-2 (FGF-2) and vascular endothelial factor (VEGF), may play critical role in the development progression RA joint disease, little information is now available regarding their exact initiation and/or RA. In this study, we show that both polypeptides were up-regulated rat tissue an adjuvant-induced model (AIA), as well...
Evidence suggests that cardiac remodeling, including left ventricular hypertrophy and myocardial fibrosis, develops with progression of kidney disease. Few studies have examined pathology across a range estimated glomerular filtration rates (eGFRs), which was the objective this investigation.Population-based cross-sectional study deceased patients undergoing autopsy.334 694 consecutive autopsy available tissue, prior health examination within 6 years without diagnosis heart disease.eGFR.The...
Abstract Background: β‐Catenin is known as a multifunctional protein acting regulator of the cadherin‐mediated cell–cell adhesion system and in Wingless/Wnt signal transduction pathway. Recent studies reported mutation β‐catenin gene some tissues hepatocellular carcinoma (HCC). Methods: ‘Nodule‐in‐nodule’ appearance feature well‐differentiated HCC containing distinct nodule less‐differentiated cancer tissue inside, it presumed to be morphological expression dedifferentiation process. The...