A5009445050- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Cancer, Lipids, and Metabolism
- Chemokine receptors and signaling
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Urinary Bladder and Prostate Research
- Liver physiology and pathology
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Pelvic floor disorders treatments
- Hormonal and reproductive studies
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Urinary Tract Infections Management
- Bone health and treatments
- Fibroblast Growth Factor Research
- Radiopharmaceutical Chemistry and Applications
- Wnt/β-catenin signaling in development and cancer
- Neutropenia and Cancer Infections
Kyushu University
1958-2025
Kanazawa University
2016-2025
Meiji University
1987-2021
Hidaka Hospital
2020-2021
Kanazawa University Hospital
2021
Hirosaki University
2020
Sasaki Institute
2020
National Natural Science Foundation of China
2020
Muroran Institute of Technology
2020
Ishikawa Prefectural Central Hospital
2015
Previous studies have found that tumor-associated macrophages (TAMs) promote cancer progression. We previously reported TAMs prostate metastasis via activation of the CCL2-CCR2 axis. The CCR4 (receptor CCL17 and CCL22) expression level in breast was to be associated with lung metastasis. aim this study elucidate role CCR2 were expressed human cell lines tissues. In vitro co-culture cells resulted increased CCL2 levels cells. addition induced CCL22 production migration invasion enhanced...
Understanding the mechanism of lymph node metastasis, a poor prognostic sign for prostate cancer, and further dissemination disease is important to develop novel treatment strategies. Recent studies have reported that C‐C chemokine receptor 7 ( CCR 7), whose ligand CCL 21, abundantly expressed in metastasis promotes cancer progression. Tumor necrosis factor‐α TNF ‐α) chronically produced at low levels within tumor microenvironment. The aim this study was determine whether ‐α from metastatic...
To examine which preoperative factors, including urodynamic evaluations, and operative procedures could predict continence status after robot-assisted radical prostatectomy (RARP) in this study.Univariate multivariate logistic regression analyses of factors such as age, body mass index, prostate-specific antigen level before biopsy, prostate size surgery, membranous urethral length measured using magnetic resonance imaging (MRI), bladder compliance maximum closure pressure (MUCP) by study...
Background Balance dysfunction is common in stroke patients. The Berg Scale (BBS) useful for evaluating the balance function of patients, and it can estimate minimal clinically important difference (MCID) balance. BBS scores differ among patients depending on whether they require walking assistance. MCID should thus be estimated separately who assistance those do not.Objectives To individuals have had an early subacute a aid not, to assist clinical determination effectiveness therapy.Methods...
Activators of peroxisome proliferator–activated receptor γ (PPARγ), which forms a heterodimer with retinoic X (RXR), inhibit the production certain inflammatory mediators. To clarify role PPARγ:RXR signaling pathway in Kupffer cells, we studied effect an RXR agonist and PPARγ on LPS–induced nitric oxide (NO) tumor necrosis factor–α (TNF–α) production. An RXR–specific agonist, Ro47–5944, PPARγ–specific AD4833 (pioglitazone hydrochloride), each inhibited NO TNF–α The combined treatment...
Abstract Background: Hepatitis C virus (HCV) and hepatitis B (HBV) are not only hepatotropic, but also lymphotropic viruses. Recently, some reports suggested that these viruses may participate in the development of malignant lymphoproliferative disorders. Methods: We investigated prevalence HCV or HBV infection 348 patients with non‐Hodgkin's lymphoma (NHL). compared prevalences those blood donors as a control group representing general population our area ( n = 1 513 358). Next, we...
This study investigated tumor-associated macrophages activity in the microenvironment of renal cell carcinoma. Via a co-culture with macrophage-like cells differentiated from human monocyte line THP-1 and U937 cells, migration ability ACHN Caki-1 which are carcinoma was significantly increased, as epithelial-mesenchymal transition change. A chemokine array identified CCL20-CCR6 axis concentration-dependent signal migration. Akt activated by CCL20 neutralizing antibody suppressed ability,...
Understanding the mechanism of chemoresistance and disease progression in patients with prostate cancer is important for developing novel treatment strategies. In particular, resistance to cabazitaxel a major challenge docetaxel‐resistant castration‐resistant (CRPC) because often administered as last resort. However, by which develops still unclear. C‐C motif chemokine ligands (CCL) were shown contribute castration cells via an autocrine mechanism. Therefore, we focused on CCL key factors...
To analyze perioperative blood pressure in patients undergoing transurethral resection of bladder tumor with photodynamic diagnosis.A total 109 consecutive who underwent diagnosis-assisted at Kanazawa University, Kanazawa, Ishikawa, Japan, were included this study and considered as the diagnosis group. Clinical data collected, systolic vasopressor usage analyzed. In contrast, previously conventional (without use oral 5-aminolevulinic acid) used control group.The before anesthesia, lowest...
SUMMARY 1. In the present study, we investigated preventive effects of pirfenidone (PFD), an antifibrotic agent, on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. 2. Treatment with DMN caused a significant decrease bodyweight and liver weight. Oral PFD (500 mg/kg daily for 4 weeks) essentially prevented this DMN‐induced loss tended to suppress There were no differences weight serum L ‐alanine aminotransferase levels between PFD‐treated ‐untreated groups....
// Kouji Izumi 1 , Atsushi Mizokami Hsiu-Ping Lin 2 Hui-Min Ho Hiroaki Iwamoto Aerken Maolake Ariunbold Natsagdorj Yasuhide Kitagawa Yoshifumi Kadono Hiroshi Miyamoto 3 Chiung-Kuei Huang 4 Mikio Namiki and Wen-Jye Department of Integrative Cancer Therapy Urology, Kanazawa University Graduate School Medical Science, Kanazawa, Japan Immunology Research Center, National Health Institutes, Zhunan, Miaoli County, Taiwan Departments Pathology Johns Hopkins Medicine, Baltimore, MD, USA The Warren...
Background Coffee inhibits the progression of prostate cancer; however, direct mechanism through which coffee acts on cancer cells remains unclear. This study aimed to identify key compounds that possess anti‐cancer effects and investigate their mechanisms action. Methods The anti‐proliferation anti‐migration six potentially active types compounds, including kahweol acetate, cafestol, caffeine, caffeic acid, chlorogenic trigonelline hydrochloride, were evaluated using LNCaP, LNCaP‐SF, PC‐3,...
Abstract Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, multiple potential pharmacological actions both yet to be fully understood. This study therefore investigated effects acetate cafestol on human cancer ACHN Caki-1 cells. Accordingly, combination administration...
Once castration-resistant prostate cancer (CRPC) become resistant for cabazitaxel treatment, the patients are obliged to best supportive care. Therefore, elucidation of mechanism cabazitaxel-resistance and conquest important themes improve prognosis patients. Then we tried establish cabazitaxel-resistant CRPC cell lines characterized them. We established two lines, PC-3-TxR/CxR DU145-TxR/CxR from PC-3-TxR DU145-TxR previously established. cells became by 11.8-fold 4.4-fold, respectively. The...
Chemokines and their receptors have key roles in cancer progression. The present study investigated chemokine activity the prostate bone metastasis microenvironment. Growth migration of human cells were assayed cocultures with stromal cells. LNC aP significantly increased when co‐cultured isolated from metastases. Cytokine array analysis conditioned medium cell cultures identified CCL 5 as a concentration‐dependent promoter migration. was suppressed C‐C motif ligand ( 5) neutralizing...
Abstract Background Visceral metastasis (VM), an important poor prognostic factor of prostate cancer (PC), is not commonly observed in castration sensitive status but often after castration‐resistant progression. However, the site, timing emergence, and incidence VM patients have yet been fully elucidated. Methods Demographic, surgical, pathological, follow‐up data PC treated at Kanazawa University Hospital between January 2000 December 2016 were retrospectively analyzed using their medical...
Enfortumab vedotin (EV) is an established pharmacotherapy for metastatic urothelial carcinoma (mUC); however, its adverse events (AEs) cannot be overlooked. The study investigated the efficacy and safety of biweekly EV administration.
Castration-resistant prostate cancer (CRPC) represents a significant difficulty in oncology, with limited treatment options and decreasing survival rates. The comprehensive genomic profiling (CGP) test has appeared as promising tool for personalizing according to the genetic characteristics of tumors. In Japan, incidence (PC) sharply increased, making it crucial investigate effective therapies informed by data. This study retrospectively analyzed data from 30 patients who underwent CGP at...