A5070739005- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Liver physiology and pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Colorectal Cancer Treatments and Studies
- PI3K/AKT/mTOR signaling in cancer
- Fibroblast Growth Factor Research
- Reproductive System and Pregnancy
- Organoselenium and organotellurium chemistry
- Garlic and Onion Studies
- Liver Diseases and Immunity
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Viral-associated cancers and disorders
- Neuroendocrine Tumor Research Advances
National Hospital Organization Kyushu Cancer Center
2016-2025
Pharmac
2022
Yamaguchi University
2020
Kyoto University
2012
Kyushu University
1998-2005
National Kyushu Medical Center
2002
Medical Center Hospital
2002
St. Petersburg Institute of Bioregulation and Gerontology
2002
University of California, Santa Barbara
1984
Asthma and atopy show epidemiological association are biologically linked by T-helper type 2 (Th2) cytokine-driven inflammatory mechanisms. IL-4 operates through the receptor (IL-4R, a heterodimer of IL-4Rα either γc or IL-13Rα1) IL-13 IL-13R (a to promote IgE synthesis IgE-based mucosal inflammation which typify atopy. Recent animal model data suggest that is central cytokine in promoting asthma, stimulation bronchial epithelial mucus secretion smooth muscle hyper-reactivity. We...
The Hakata antigen is a novel, thermolabile beta2-macroglycoprotein that reacts with sera from patients suffering systemic lupus erythematosus. In this study we present the structure and function of antigen. We have identified cDNA clones encoding analyzed its function. included possible open reading frame 897 nucleotides, 299 amino acids. consisted collagen-like domain in middle section fibrinogen-like COOH terminus, both which are homologous to human ficolin-1 opsonin P35, indicating these...
Sorafenib (Sor) is acknowledged as a standard therapy for advanced hepatocellular carcinoma (HCC). This trial was conducted to evaluate the effect of addition hepatic arterial infusion chemotherapy with cisplatin (SorCDDP) Sor treatment HCC.We multicenter open-labeled randomized phase II in chemo-naïve patients HCC Child-Pugh scores 5-7. Eligible were randomly assigned 2:1 receive SorCDDP (sorafenib: 400 mg bid; cisplatin: 65 mg/m2, day 1, every 4-6 weeks) or (400 bid). The primary end point...
Nonalcoholic steatohepatitis is a clinicopathologic condition that may progress to liver fibrosis. Hyperglycemia supposed be one of the factors inducing hepatic fibrogenesis, but mechanism has not been fully clarified. Oxidative stress increasingly found in patients with diabetes/hyperglycemia which conditions reactive oxygen species (ROS) are produced.We performed experiments using stellate cells (HSCs) culture order confirm effect high glucose concentrations on cell proliferation, type I...
Summary Background Tenofovir alafenamide (TAF) may be preferable to other nucleos(t)ide analogues (NA) regarding outcomes against chronic hepatitis B virus (HBV) infection. Aims To evaluate the longer term virological/biochemical effectiveness of TAF and renal safety sequential therapy in real‐world settings Methods This multi‐centre, retrospective cohort study included consecutive adult patients who were switched from NAs TAF. We assessed virological biochemical responses up 144 weeks....
A comparison between atezolizumab plus bevacizumab (ATEZO/BEVA) and lenvatinib (LEN) for the treatment of hepatocellular carcinoma (HCC) remains unclear.This study aimed to compare therapeutic effects safety ATEZO/BEVA LEN as first-line therapies HCC.This was a retrospective analysis 810 patients with HCC who underwent (n = 186) or 624) systemic therapy March 2018 2022 at 14 facilities. After propensity score matching, 304 (ATEZO/BEVA group: n 152; 152) were analyzed.After although there no...
Activators of peroxisome proliferator–activated receptor γ (PPARγ), which forms a heterodimer with retinoic X (RXR), inhibit the production certain inflammatory mediators. To clarify role PPARγ:RXR signaling pathway in Kupffer cells, we studied effect an RXR agonist and PPARγ on LPS–induced nitric oxide (NO) tumor necrosis factor–α (TNF–α) production. An RXR–specific agonist, Ro47–5944, PPARγ–specific AD4833 (pioglitazone hydrochloride), each inhibited NO TNF–α The combined treatment...
Hakata antigen was first reported as a serum protein that reacted with an autoantibody from patients systemic lupus erythematosus. Recently, it has been found is new member of the ficolin/opsonin p35 family, which distinct lectin on basis homology structures and common characteristic possessing activity. In this study we analyzed tissue distribution antigen. mRNA were generated in lung liver. lung, produced by both ciliated bronchial epithelial cells Type II alveolar secreted into bronchus...
Abstract: Background: Recently, it has been reported that interleukin 4 (IL‐4) and 13 (IL‐13) directly activate fibroblasts promote fibrosis. In the process of hepatic fibrosis, effects these cytokines on stellate cells (HSCs) are not well known. Methods: We evaluated IL‐4 IL‐13 collagen production proliferation LI90, a cell line. also examined whether interferon (IFN) interferes with expression collagen, since IFN to clinically suppress Results: The receptor complex for was IL‐4Rα/IL‐13Rα1...
Not all patients with hepatocellular carcinoma (HCC) benefit from treatment molecular targeted agents such as sorafenib. We investigated whether New-FP (fine-powder cisplatin and 5-fluorouracil), a hepatic arterial infusion chemotherapy regimen, is more favorable than sorafenib an initial for locally progressed HCC.To avoid selection bias, we corrected the data different facilities that did or not perform therapy. In total, 1709 consecutive HCC initially treated sorafenib; 1624 (New-FP, n =...
SUMMARY 1. In the present study, we investigated preventive effects of pirfenidone (PFD), an antifibrotic agent, on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. 2. Treatment with DMN caused a significant decrease bodyweight and liver weight. Oral PFD (500 mg/kg daily for 4 weeks) essentially prevented this DMN‐induced loss tended to suppress There were no differences weight serum L ‐alanine aminotransferase levels between PFD‐treated ‐untreated groups....
IL-4 and IL-13 are pleiotropic cytokines whose biological activities overlap with each other. receptor alpha chain 1 (IL-13R 1) is necessary for binding to IL-13, the heterodimer composed of IL-13R IL-4R transduces signals; however, functional mapping intracellular domain not fully understood. In this study, we constructed wild mutated types human 1, analyzed signals using an 1-transfected B cell line. Expression evoked STAT3 activation by in stimulated cells, on which was highly expressed,...
587 Background: The Phase 2 CHALLENGE trial (jRCTs031210355) evaluated the safety and efficacy of atezo+bev combination therapy in patients with advanced HCC Child–Pugh class B cirrhosis. Results trial’s main analysis demonstrated that was well-tolerated. Here, we present final outcomes. Methods: This multicenter, open-label, single-arm, study enrolled a score 7 or 8 who had not received prior systemic therapy. Patients were administered atezolizumab 1200 mg plus bevacizumab 15 mg/kg every 3...
ABSTRACT Background and Aim More accurate stratification of patients with chronic hepatitis C after permanent virus (HCV) clearance by direct‐acting antivirals (DAAs) is important for improving long‐term surveillance treatment. The aim this study was to stratify who are at risk developing hepatocellular carcinoma (HCC) HCV cure. Methods This multicenter, retrospective cohort included 3177 consecutive adult without decompensated cirrhosis were treated all‐oral DAAs. primary endpoints...
Abstract Background: Claudin-18 (CLDN18) is a major component of tight junctions located on the cell membrane surface. CLDN18.1 and CLDN18.2 are specifically expressed in normal lung tissues gastric mucosa, respectively. However, CNDN18.2 known to be frequently cancer, also overexpressed pancreatic cancer (PC) 30-60% cases. Clinical features PC due CLDN18 expression have been reported limited number cases, molecular remain unknown. Here, we evaluated clinical characterization...
Although physiological studies have shown evidence of phase resetting during fictive locomotion, the functional roles in actual locomotion remain largely unclear. In this paper, we constructed a control system for biped robot based on findings and investigated gait transition from quadrupedal to bipedal by numerical simulations experiments. So far, although many methods achieve stable locomotor behaviors various patterns legged robots, their transitions not been thoroughly examined....
In response to the bacterial endotoxin, LPS, Kupffer cells are induced express NO and TNF-alpha. These compounds involved in hepatic inflammation/injury, especially that associated with endotoxic shock. this study, we demonstrate ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one), a selenoorganic compound, blocks LPS-induced TNF-alpha production by cultured rat liver cells. LPS can activate both NF-kappaB signaling pathway MAPK signal transduction pathways such as JNK p38 MAPK. We find...
The prognosis of patients with hepatocellular carcinoma (HCC) may be improved by novel treatments focusing on the characteristic metabolic changes this disease. Therefore, we analyzed biological interactions features degree tumor differentiation and level malignant potential in 41 completely resectable HCC. expression levels resected samples mRNAs encoded genes related to metabolism metastasis were investigated, correlation between these degrees was analyzed. Of patients, 2 had grade I, 27...