A5045293577- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Neuropeptides and Animal Physiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adipose Tissue and Metabolism
- Pancreatic and Hepatic Oncology Research
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Analytical chemistry methods development
- Inflammatory Biomarkers in Disease Prognosis
- Neonatal Health and Biochemistry
- Neuroendocrine regulation and behavior
- Ion-surface interactions and analysis
- Gallbladder and Bile Duct Disorders
- Nutrition and Health in Aging
- Diet and metabolism studies
- Mass Spectrometry Techniques and Applications
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Nuclear Physics and Applications
- Hormonal Regulation and Hypertension
Kyushu University
2016-2025
Kyushu University Hospital
2016-2024
Hokkaido University of Science
2019-2021
Hokkaido University
1971-2020
St. Paul's Hospital
2018
Fukuoka City Hospital
2011-2017
National Institute for Materials Science
2003-2017
Gangnam Severance Hospital
2017
Yonsei University
2017
Kumamoto University
2016
The tyrosine kinase inhibitor lenvatinib is used to treat advanced hepatocellular carcinoma (HCC). Ferroptosis a type of cell death characterized by the iron-dependent accumulation lethal lipid reactive oxygen species (ROS). Nuclear factor erythroid-derived 2-like 2 (Nrf2) protects HCC cells against ferroptosis. However, mechanism lenvatinib-induced cytotoxicity and relationships between resistance Nrf2 are unclear. Thus, we investigated relationship ferroptosis clarified involvement in...
Abstract The microvascular invasion of cancer cells (mvi) is a good prognostic factor after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). aim this study to predict mvi in patients with HCC who were candidates OLT. We studied 218 resections had without any extrahepatic metastases and vascular detected during preoperative evaluation. analyzed the clinico‐pathological data these presence. prediction scoring system was made accuracy examined using independent...
Aim The present study investigated the effect of sarcopenia on short‐ and long‐term surgical outcomes identified potential prognostic factors for hepatocellular carcinoma (HCC) following hepatectomy among patients 70 years age older. Methods Patient data were retrospectively collected 296 consecutive who underwent HCC with curative intent. Patients assigned to two groups according (younger than years, older), presence sarcopenia. clinicopathological, outcome, survival analyzed. Results...
Background and Aims We investigated the prognostic value of programmed death ligand 1 (PD‐L1) expression, tumor‐infiltrating CD8‐positive T‐cell status, their combination in hepatocellular carcinoma (HCC). Their association with PD‐L1 expression vascular formation was further explored. Approach Results Using a database 387 patients who underwent hepatic resection for HCC, immunohistochemical staining PD‐L1, CD8, CD34 performed. Additionally, we undertook an enzyme‐linked immunosorbent assay...
Hepatic stellate cells (HSCs) play a central role in hepatic fibrosis and are regulated by Kupffer (KCs). Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+ -M2BP) was recently identified as serum marker for fibrosis. Although WFA+ -M2BP ligand of Mac-2, the function remains unclear.Liver specimens were obtained from five patients with cirrhosis, chronic hepatitis, without kinetics evaluated histologically subpopulations liver such HSCs, KCs, endothelial cells, biliary...
UDP-glucuronyltransferase activities towards 2-aminophenol and bilirubin were studied in a total of 70 human subjects, including premature full-term newborn babies, infants, children adults. These two have been reported rat to develop latefoetally neonatally respectively, but man they both neonatally. There is linear relationship between the logarithm each liver transferase activity number days after birth during first 3 months life, which remains constant.
Although hepatocellular carcinoma (HCC) is the most common cancer of human liver, mechanisms that regulate HCC development and progression remain unclear. The aim this study was to investigate whether focal adhesion kinase (FAK) involved in HCC.Western blot analysis for FAK performed on three cell lines. We reviewed 64 consecutive patients who had undergone initial liver resection without preoperative treatment. Immunohistochemistry paraffin-embedded tissues. expression confirmed by Western...
Small-for-size syndrome (SFSS) is the most significant cause of graft loss after living donor liver transplantation (LDLT), especially left lobe (LL) LDLT in adults. The safety limit applying LL-LDLT adults without severe SFSS with a high rate lethality needs to be determined. A total 207 LL-LDLTs since September 2005 were evaluated analyze risk factors for SFSS, defined as serum bilirubin concentration ≥20.0 mg/dL LDLT. Although there no differences cumulative survival between medium grafts...
Cancer-related inflammation has been correlated with cancer prognosis. This study evaluated inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR), programmed death ligand (PD-L) 1 expression, tumour microenvironment in relation to prognosis clinicopathological features of patients hepatocellular carcinoma (HCC) undergoing curative hepatic resection. Patients who had liver resection for HCC 2000–2011 were...
A comparison between atezolizumab plus bevacizumab (ATEZO/BEVA) and lenvatinib (LEN) for the treatment of hepatocellular carcinoma (HCC) remains unclear.This study aimed to compare therapeutic effects safety ATEZO/BEVA LEN as first-line therapies HCC.This was a retrospective analysis 810 patients with HCC who underwent (n = 186) or 624) systemic therapy March 2018 2022 at 14 facilities. After propensity score matching, 304 (ATEZO/BEVA group: n 152; 152) were analyzed.After although there no...
Abstract We examined the epidemiological trends, including distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data 20,547 patients (1996–2019) were analyzed this prospective study. divided study period into four 6-yearly quarters. etiology was categorized as hepatitis B virus (HBV) infection, HBV + C (HCV) HCV both negative (non-BC). The cases per quarter 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) male....
PURPOSE Durable partial response (PR) and durable stable disease (SD) are often seen in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab (atezo-bev). This study investigates the outcome of these histopathology residual tumors. PATIENTS AND METHODS The IMbrave150 study's atezo-bev group was analyzed. PR or SD per RECIST v1.1 lasting more than 6 months defined as durable. For histologic analysis, a comparable real-world from Japan Taiwan who had undergone...
Background. Transient elastography (FibroScan) is a simple and noninvasive method to assess liver fibrosis by measuring stiffness therefore can be promising tool evaluate avoid biopsy. We prospectively assessed the performance of transient in patients with recurrent hepatitis C virus after living donor transplantation, comparison surrogate serum markers. Methods. Fifty-six who underwent both biopsy were included this study. The grade (the Scheuer classification) obtained was compared...
Photobilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant was demonstrated for first time by reversed-phase high-pressure liquid chromatography. The concentrations increased significantly during phototherapy. Corresponding to these changes serum, biliary unconjugated bilirubin markedly but photobilirubin-IX not detected bile. Moreover, large amounts ‘unknown pigment’ that are diazo-negative appeared bile