A5077171428- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Hepatitis C virus research
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Clinical Nutrition and Gastroenterology
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Treatments and Studies
- Viral-associated cancers and disorders
- Genetic factors in colorectal cancer
Kyushu University
2016-2025
Kyushu University Beppu Hospital
2022-2024
Kyushu University Hospital
2021-2024
The University of Tokyo
2022
St. Paul's Hospital
2018
Okayama University Hospital
2016-2018
Matsuyama Red Cross Hospital
2016-2017
Development Fund
2012
Fundación Juan March
2009
The tyrosine kinase inhibitor lenvatinib is used to treat advanced hepatocellular carcinoma (HCC). Ferroptosis a type of cell death characterized by the iron-dependent accumulation lethal lipid reactive oxygen species (ROS). Nuclear factor erythroid-derived 2-like 2 (Nrf2) protects HCC cells against ferroptosis. However, mechanism lenvatinib-induced cytotoxicity and relationships between resistance Nrf2 are unclear. Thus, we investigated relationship ferroptosis clarified involvement in...
Background and Aims We investigated the prognostic value of programmed death ligand 1 (PD‐L1) expression, tumor‐infiltrating CD8‐positive T‐cell status, their combination in hepatocellular carcinoma (HCC). Their association with PD‐L1 expression vascular formation was further explored. Approach Results Using a database 387 patients who underwent hepatic resection for HCC, immunohistochemical staining PD‐L1, CD8, CD34 performed. Additionally, we undertook an enzyme‐linked immunosorbent assay...
Autophagy is a homeostatic mechanism that regulates protein and organelle turnover uses the amino acids from degraded proteins to produce adenosine 5′-triphosphate (ATP). We investigated activity of autophagy-associated pathways in liver regeneration after partial hepatectomy (PHx) liver-specific autophagy-related gene 5 (Atg5) knockout (KO) mice. Liver was severely impaired by 70% PHx, with reduction postoperative mitosis, but compensating increase hepatocyte size. PHx induced intracellular...
Abstract Background & Aims The microvascular invasion of cancer cells (mvi) is a good prognostic factor after hepatic resection ( HR ) and liver transplantation for hepatocellular carcinoma HCC ). This study aimed to predict mvi in patients with . Methods We studied 63 hepatectomized who had without any extrahepatic metastases vascular invasion, which were detected during preoperative evaluation. clinicopathological data these analysed presence mvi. A scoring system was designed using...
Depletion of skeletal muscle mass (sarcopenia) predicts survival in patients with cancer or liver cirrhosis. Recently, many reports have used computed tomography (CT) to measure area define sarcopenia. However, the definition sarcopenia using CT has not been fully determined. The aim this study was establish formulae calculate standard muscle.Forty-five healthy adults (24 men and 21 women, aged 21-66 years) who wished donate part their for transplantation underwent CT. Cross-sectional areas...
In living-donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC), it is important to predict not only who may be susceptible recurrence but also survive longer. The neutrophil/lymphocyte ratio (NLR) useful properly assess the patient without decreasing long-term survival after LDLT. this study, we investigated relationship between NLR and prognosis of patients with recurrent HCC LDLT.In total, 167 LDLTs were enrolled in study. Clinicopathologic factors LDLT prognostic examined...
Cancer-related inflammation has been correlated with cancer prognosis. This study evaluated inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR), programmed death ligand (PD-L) 1 expression, tumour microenvironment in relation to prognosis clinicopathological features of patients hepatocellular carcinoma (HCC) undergoing curative hepatic resection. Patients who had liver resection for HCC 2000–2011 were...
Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of lymphocyte-to-monocyte ratio (LMR) patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). retrospectively analyzed records 216 LDLT HCC. Patients were divided into high (n = 126) and low 90) LMR groups. Their clinicopathological parameters survival times compared. To determine mechanisms change LMR,...
Abstract The processing of intracellular reactive oxygen species (ROS) by nuclear factor erythroid‐derived 2‐like 2 (Nrf2) and NADPH quinone oxidoreductase 1 (Nqo1) is important for tumor metastasis. However, the clinical biological significance Nrf2/Nqo1 expression in hepatocellular carcinoma (HCC) remains unclear. We aimed to clarify importance HCC evaluate association with also evaluated impact Nqo1 modulation on metastatic potential. used spheroids derived from cell lines. In...
CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) was identified as a regulator of programmed death ligand 1 (PD-L1), which induces antitumor immunity in several cancers. This study aimed to clarify the relationship between CMTM6 and PD-L1 expression clinical outcomes patients with hepatocellular carcinoma (HCC). In total, 259 HCC who had undergone hepatic resection were enrolled. Immunohistochemical staining for performed. The relationships clinicopathological characteristics...
We evaluated the prognostic value of fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC). Their association with programmed death ligand 1 (PD-L1) expression and vascular formation was further investigated. In this retrospective study, using a database 418 patients who had undergone 18F-FDG PET/CT before hepatic resection for HCC, immunohistochemical staining PD-L1, clusters differentiation (CD) 8, CD68, CD34...
This study aimed to clarify the clinical effects of indocyanine green (ICG)-fluorescence imaging (FI) technique for determination liver transection lines during laparoscopic partial resection tumors.