A5004019456- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Cancer Immunotherapy and Biomarkers
- Clinical Nutrition and Gastroenterology
- Ferroptosis and cancer prognosis
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- RNA modifications and cancer
Kyushu University
2014-2025
Kyushu University Hospital
2024
Oita Red Cross Hospital
2018-2020
Aso Iizuka Hospital
2015-2018
Novem (Netherlands)
2012
Nippon Steel Yawata Memorial Hospital
2010-2011
Background and Aims We investigated the prognostic value of programmed death ligand 1 (PD‐L1) expression, tumor‐infiltrating CD8‐positive T‐cell status, their combination in hepatocellular carcinoma (HCC). Their association with PD‐L1 expression vascular formation was further explored. Approach Results Using a database 387 patients who underwent hepatic resection for HCC, immunohistochemical staining PD‐L1, CD8, CD34 performed. Additionally, we undertook an enzyme‐linked immunosorbent assay...
Hepatocellular carcinoma (HCC) is primarily treated with hepatic resection and/or locoregional therapy. When HCC recurs and further treatment no longer possible owing to poor liver function, transplantation (LT) or living-donor LT (LDLT) considered. The aim of this study was clarify risk factors for tumor recurrence after LDLT in patients recurrent HCC.The comprised 104 who had undergone because end-stage disease HCC. recurrence-free survival rates the were calculated. Risk identified.The...
Cancer-related inflammation has been correlated with cancer prognosis. This study evaluated inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) and lymphocyte-to-monocyte (LMR), programmed death ligand (PD-L) 1 expression, tumour microenvironment in relation to prognosis clinicopathological features of patients hepatocellular carcinoma (HCC) undergoing curative hepatic resection. Patients who had liver resection for HCC 2000–2011 were...
Abstract Background & Aims Recently, the association between hepatocellular carcinoma (HCC) and ferroptosis has been focus of much attention. The expression long chain fatty acyl‐CoA ligase 4 (ACSL4), a marker ferroptosis, in tumour tissue is related to better prognosis various cancers. In HCC, ACSL4 indicates poor high malignancy. However, mechanism remains be fully understood. Methods We retrospectively enrolled 358 patients with HCC who had undergone hepatic resection....
There is increasing evidence that inflammation-based prognostic scores are stage-independent predictors of poor outcome in patients with hepatocellular carcinoma (HCC). However, these findings were observed a small-sized study comparing the value for after curative resection HCC.We retrospectively analyzed 717 consecutive HCC who underwent liver at Hiroshima Red Cross Hospital & Atomic Bomb Survivors Hospital. Clinicopathological variables including preoperative scores, such as...
The hemoglobin, albumin, lymphocyte, and platelet (HALP) score reflects the immune system nutritional status of patients, prognosis in various cancers. However, HALP hepatocellular carcinoma has not been reported.Data were analyzed retrospectively from Child-Pugh A patients undergoing hepatic resection for single ≤5 cm. For cross-validation, divided into training (332 patients) validation cohort (210 patients). In cohort, we two groups by appropriate cut-off value score, univariable...
ABSTRACT Aim With advances in systemic therapy, the number of patients with hepatocellular carcinoma (HCC) who can undergo hepatic resection has increased recent years, but there are no reports evaluating immune status peritumoral area. Methods We enrolled 14 underwent after lenvatinib (LEN, n = 7) or atezolizumab plus bevacizumab (ATZ/BEV, 5) therapy. Tumor‐infiltrating lymphocytes (TILs), including CD3+ and CD8+ TILs, area were evaluated by hematoxylin eosin staining immunohistochemistry....
Although early relaparotomy of the recipient after living-donor liver transplantation (LDLT) is a significant event, its causes, risk factors, and outcomes are still unclear.A retrospective analysis 284 cases adult-to-adult LDLT was performed.The incidence 9.2% (n=26). The reasons for were divided into three groups: postoperative bleeding (n=11, 42.3%), insufficient portal venous flow (n=5, 19.2%), other (n=10, 38.5%). 6-month graft survival rates patients in laparotomy nonlaparotomy groups...
Solitary fibrous tumors (SFTs) are uncommon mesenchymal neoplasms that present most commonly at intrathoracic sites. SFTs of the liver rare, with only a few having been reported in English-language literature. We report rare case hepatic SFT and literature review.A 49-year-old woman underwent surgery for cranial hemangiopericytoma two decades previously. She currently presented malaise. Abdominal computed tomography (CT) showed huge, sharply demarcated mass anterior segment liver. Tumor...
Autophagy is a homeostatic process regulating turnover of impaired proteins and organelles, p62 (sequestosome‐1, SQSTM1 ) functions as the autophagic receptor in this process. also hub for intracellular signaling such that mammalian target rapamycin (mTOR) pathway. Liver stem/progenitor cells have potential to differentiate form hepatocytes or cholangiocytes. In study, we examined effects autophagy, p62, associated on hepatic differentiation. Adult were isolated from liver mice with...