A5086355553- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- Pancreatic and Hepatic Oncology Research
- HIV-related health complications and treatments
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pancreatitis Pathology and Treatment
The University of Tokyo
2012-2025
University of Tokyo Hospital
2013-2024
Tokyo University of Science
2021-2023
Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers
2014-2023
National Institute of Infectious Diseases
2020-2022
Oita Prefectural Hospital
2016
Kyushu University
1992-2013
Infectious Disease Research Institute
2012
Advanced Medical Research Institute
2012
National Hospital Organization Kyushu Cancer Center
1995-2011
Reverse transcription-quantitative PCR (RT-qPCR)-based tests are widely used to diagnose coronavirus disease 2019 (COVID-19). As a result that these cannot be done in local clinics where RT-qPCR testing capability is lacking, rapid antigen (RATs) for COVID-19 based on lateral flow immunoassays diagnosis. However, their sensitivity compared with each other and infectious virus isolation has not been examined. Here, we the among four RATs by using severe acute respiratory syndrome 2...
BackgroundTo develop an effective vaccine against a novel viral pathogen, it is important to understand the longitudinal antibody responses its first infection. Here we performed study of SARS-CoV-2 in symptomatic patients.MethodsSequential blood samples were collected from 39 individuals at various timepoints between 0 and 154 days after onset. IgG or IgM titers receptor binding domain (RBD) S protein, ectodomain N protein determined by using ELISA. Neutralizing measured plaque reduction...
The purpose of this study was to clarify the factors linked recurrence small hepatocellular carcinomas, up 3cm in diameter, after hepatectomy. Fifty patients with carcinomas who underwent hepatectomy between 1976 and 1988 were observed for possible at least 2 yr. These divided into two groups: 20 had within yr 30 no pattern analyzed by hepatic angiography. Statistical analysis X2 test stepwise logistic regression showed that risk (a) tumor diameter greater than 2.2 cm, (b) intracapsular...
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are of concern, with the P.1 dominating in Brazil. Brazil is now seeing a record number deaths. Here, we report that pathogenicity hamsters variant similar to nonvariant SARS-CoV-2. However, it has an expanded host range as shown by its replication mice. Prior infection SARS-CoV-2 strains efficiently prevented lower tract upon reinfection. Convalescent sera from patients infected nonvariants or messenger RNA...
Limited knowledge exists on immune markers associated with disease severity or recovery in patients coronavirus 2019 (COVID-19). Here, we elucidated longitudinal evolution of SARS-CoV-2 antibody repertoire acute COVID-19. Differential kinetics was observed for immunoglobulin M (IgM)/IgG/IgA epitope diversity, binding, and affinity maturation "severe" versus "mild" COVID-19 patients. IgG profile demonstrated immunodominant antigenic sequences encompassing fusion peptide receptor binding...
The role of the intestinal microbiota in coronavirus disease 2019 (COVID-19) is being elucidated. Here, we analyzed temporal changes composition and correlation between inflammation biomarkers/cytokines hospitalized COVID-19 patients. We obtained stool specimens, blood samples, patient records from 22 patients performed 16S rRNA metagenomic analysis samples over course onset compared to 40 healthy individual samples. gut plasma proinflammatory cytokine levels. Immediately after admission,...
Chronic inflammation is a hallmark of HIV infection and associated with the development progression age-related comorbidities. Although gastrointestinal tract major site replication CD4 + T-cell depletion, role HIV-associated imbalance gut microbiome in chronic unclear.
Abstract Background People living with HIV (PLWH) chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed temporal changes in composition hospitalized severe acute respiratory syndrome 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and correlation severity. Result The 16S rRNA analysis results using stool samples (along timeline from onset) 12 PLWH-CoV, whose...
The postoperative intrahepatic recurrence of hepatocellular carcinoma (HCC) is high. It difficult to distinguish whether the metastatic or new primary lesion. To determine malignant potential HCC itself, we analyzed risk factors associated with portal venous invasion since this direct evidence tumor invasiveness.Two hundred and thirty-two patients who underwent curative hepatectomy for without preoperative treatments were included in study, because treatment caused undergo a variety...
Spindle cell hepatocellular carcinoma (SpHCC) has rarely been reported, and its clinicopathologic characteristics, histogenesis, prognosis after hepatic resection have yet to be clarified.Fifteen cases of SpHCC, including 13 surgically resected patients 2 autopsy cases, were studied clinicopathologically immunohistochemically.In patients, all except 1 male the serum alpha-fetoprotein (AFP) was positive in 6 (46%). Portal venous invasion intrahepatic metastases frequent. In an...
The effects of preoperative transcatheter arterial chemoembolization (TAE) for hepatocellular carcinoma (HCC) remain a matter controversy.Seventy-two patients with HCC were entered in the study; did not have risk factors disease recurrence tumor larger than 5 cm diameter, presence venous invasion, or intrahepatic metastasis. Only 3 years follow-up after curative resection selected. Forty-six underwent TAE (Group I) and 26 undergo II). Group I was divided into three subgroups according to...
HLA‐A, ‐C, ‐B, and ‐DRB1 genotypes were analyzed in 178 Japanese COVID‐19 patients to investigate the association of HLA with severe COVID‐19. Analysis 32 common alleles at four loci revealed a significant between HLA‐DRB1*09:01 (odds ratio [OR], 3.62; 95% CI, 1.57–8.35; p = 0.00251 [permutation value 0.0418]) when age, sex, other DRB1 locus adjusted. The DRB1*09:01 allele was more significantly associated risk for compared preexisting medical conditions such as hypertension, diabetes,...